| Literature DB >> 8236461 |
R Kemler1.
Abstract
Classical cadherins are complexed via their cytoplasmic domains with alpha-, beta- and gamma-catenin. This complex formation links cadherins to the actin filament network and to other transmembrane and cytoplasmic proteins. alpha-Catenin is homologous to vinculin, and beta-catenin to the product of the Drosophila gene armadillo, while gamma-catenin seems to be identical to plakoglobin. Catenins are part of a higher order protein structure that is of crucial importance for the adhesive function of cadherins. A working model of the construction and regulation of this multiprotein interaction is proposed.Entities:
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Year: 1993 PMID: 8236461 DOI: 10.1016/0168-9525(93)90250-l
Source DB: PubMed Journal: Trends Genet ISSN: 0168-9525 Impact factor: 11.639