Karen J Coleman1, Yu-Hsiang Shu, Heidi Fischer, Eric Johnson, Tae K Yoon, Brianna Taylor, Talha Imam, Stephen DeRose, Sebastien Haneuse, Lisa J Herrinton, David Fisher, Robert A Li, Mary Kay Theis, Liyan Liu, Anita P Courcoulas, David H Smith, David E Arterburn, Allon N Friedman. 1. Kaiser Permanente Southern California, Department of Research and Evaluation, Pasadena, CA Kaiser Permanente Washington Health Research Institute, Seattle, WA Kaiser Permanente Southern California, Nephrology Department, San Bernardino Medical Center, Fontana, CA Harvard T. H. Chan School of Public Health, Boston, MA Kaiser Permanente Northern California, Division of Research, Oakland, CA Kaiser Permanente Northern California, Department of Surgery, Oakland, CA. Kaiser Permanente Northern California, Division of Research Oakland, CA. University of Pittsburgh Medical Center, School of Medicine, Pittsburgh, PA Kaiser Permanente Northwest, Center for Health Research, Portland, OR Division of Nephrology Indiana University School of Medicine, Indianapolis, IN.
Abstract
OBJECTIVE: A retrospective cohort study investigated the association between having surgery and risk of mortality for up to five years and if this association was modified by incident End Stage Renal Disease (ESRD) during the follow-up period. SUMMARY BACKGROUND DATA: Mortality risk in individuals with pre-dialysis chronic kidney disease (CKD) is high and few effective treatment options are available. Whether bariatric surgery can improve survival in people with CKD is unclear. METHODS: Patients with class II and III obesity and pre-dialysis CKD stages 3 - 5 who underwent bariatric surgery between 1/1/2006 and 9/30/2015 (n = 802) were matched to patients who did not have surgery (n = 4,933). Mortality was obtained from state death records and ESRD was identified through state-based or healthcare system-based registries. Cox regression models were used to investigate the association between bariatric surgery and risk of mortality and if this was moderated by incident ESRD during the follow-up period. RESULTS: Patients were primarily women (79%), non-Hispanic White (72%), under 65 years old (64%), who had a BMI ≥ 40 kg/m2 (59%), diabetes (67%) and hypertension (89%). After adjusting for incident ESRD, bariatric surgery was associated with a 79% lower 5-year risk of mortality compared to matched controls (HR = 0.21; 95% CI: 0.14-0.32; p < .001). Incident ESRD did not moderate the observed association between surgery and mortality (HR = 1.59; 95% CI 0.31-8.23; p = .58). CONCLUSIONS: Bariatric surgery is associated with a reduction in mortality in pre-dialysis patients regardless of developing ESRD. These findings are significant because patients with CKD are at relatively high risk for death with few efficacious interventions available to improve survival.
OBJECTIVE: A retrospective cohort study investigated the association between having surgery and risk of mortality for up to five years and if this association was modified by incident End Stage Renal Disease (ESRD) during the follow-up period. SUMMARY BACKGROUND DATA: Mortality risk in individuals with pre-dialysis chronic kidney disease (CKD) is high and few effective treatment options are available. Whether bariatric surgery can improve survival in people with CKD is unclear. METHODS: Patients with class II and III obesity and pre-dialysis CKD stages 3 - 5 who underwent bariatric surgery between 1/1/2006 and 9/30/2015 (n = 802) were matched to patients who did not have surgery (n = 4,933). Mortality was obtained from state death records and ESRD was identified through state-based or healthcare system-based registries. Cox regression models were used to investigate the association between bariatric surgery and risk of mortality and if this was moderated by incident ESRD during the follow-up period. RESULTS: Patients were primarily women (79%), non-Hispanic White (72%), under 65 years old (64%), who had a BMI ≥ 40 kg/m2 (59%), diabetes (67%) and hypertension (89%). After adjusting for incident ESRD, bariatric surgery was associated with a 79% lower 5-year risk of mortality compared to matched controls (HR = 0.21; 95% CI: 0.14-0.32; p < .001). Incident ESRD did not moderate the observed association between surgery and mortality (HR = 1.59; 95% CI 0.31-8.23; p = .58). CONCLUSIONS: Bariatric surgery is associated with a reduction in mortality in pre-dialysis patients regardless of developing ESRD. These findings are significant because patients with CKD are at relatively high risk for death with few efficacious interventions available to improve survival.
Authors: Adeera Levin; Marcello Tonelli; Joseph Bonventre; Josef Coresh; Jo-Ann Donner; Agnes B Fogo; Caroline S Fox; Ron T Gansevoort; Hiddo J L Heerspink; Meg Jardine; Bertram Kasiske; Anna Köttgen; Matthias Kretzler; Andrew S Levey; Valerie A Luyckx; Ravindra Mehta; Orson Moe; Gregorio Obrador; Neesh Pannu; Chirag R Parikh; Vlado Perkovic; Carol Pollock; Peter Stenvinkel; Katherine R Tuttle; David C Wheeler; Kai-Uwe Eckardt Journal: Lancet Date: 2017-04-20 Impact factor: 79.321
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Authors: A Shulman; M Peltonen; C D Sjöström; J C Andersson-Assarsson; M Taube; K Sjöholm; C W le Roux; L M S Carlsson; P-A Svensson Journal: Int J Obes (Lond) Date: 2018-02-26 Impact factor: 5.095