Francis Capule1, Pramote Tragulpiankit2, Surakameth Mahasirimongkol3, Jiraphun Jittikoon4, Nuanjun Wichukchinda3, Lara Theresa Alentajan-Aleta5, Jay-V James Barit6, Josephine Casanova-Gutierrez7, Leonor Cabral-Lim7, Jose Paciano Baltazar Reyes7, Francisca Roa6, Raymark Salonga8, Katrina Faith San Gabriel5, Catherine Lynn Silao9,10. 1. Department of Pharmacy, College of Pharmacy, University of the Philippines Manila, Manila, Philippines. 2. Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. 3. Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. 4. Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. 5. Department of Medicine, Section of Allergy & Immunology, Philippine General Hospital & College of Medicine, University of The Philippines Manila, Manila, Philippines. 6. Department of Dermatology, Philippine General Hospital & College of Medicine, University of The Philippines Manila, Manila, Philippines. 7. Department of Neurosciences, Section of Adult Neurology, Philippine General Hospital & College of Medicine, University of The Philippines Manila, Manila, Philippines. 8. Graduate School, University of The East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines. 9. Institute of Human Genetics, National Institutes of Health, University of The Philippines Manila, Manila, Philippines. 10. Department of Pediatrics, Philippine General Hospital & College of Medicine, University of The Philippines Manila, Manila, Philippines.
Abstract
Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.
Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.
Entities:
Keywords:
Filipino; HLA-A*24:07; HLA-B*15:21; HLA-B75 serotype; Stevens–Johnson syndrome; antiepileptic agent; carbamazepine; human leukocyte antigen; severe cutaneous adverse drug reactions; toxic epidermal necrolysis
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