Literature DB >> 3390649

Effect of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs.

R M Tripathi1, R Kaushal.   

Abstract

1. Effects of some non-steroidal anti-inflammatory drugs on ouabain-induced arrhythmias in guinea-pigs were studied. 2. Ventricular premature beats, ventricular fibrillation and cardiac arrest were induced in pentobarbitone-anaesthetized guinea-pigs by a slow intravenous infusion of ouabain. 3. Aspirin and indomethacin were found to accord a significant protection to the guinea-pigs against arrhythmias whereas ketoprofen was found to be ineffective. 4. It is concluded that the protective effect of aspirin and indomethacin may be due to inhibition of synthesis and release of thromboxane A2 from the myocardium.

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Year:  1988        PMID： 3390649      PMCID： PMC1853872          DOI： 10.1111/j.1476-5381.1988.tb11458.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  25 in total

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5.  The antagonism between anti-inflammatory drugs and substances that constrict veins.

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6.  Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2.

Authors:  E F Ellis; O Oelz; L J Roberts; N A Payne; B J Sweetman; A S Nies; J A Oates
Journal:  Science       Date:  1976-09-17       Impact factor: 47.728

Review 7.  The mode of action of aspirin and similar compounds.

Authors:  J R Vane
Journal:  J Allergy Clin Immunol       Date:  1976-12       Impact factor: 10.793

8.  Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy.

Authors:  R Korbut; S Moncada
Journal:  Thromb Res       Date:  1978-09       Impact factor: 3.944

9.  Reduction by indomethacin of the degeneration increase in outflow facility after superior cervical ganglionectomy in the rabbit.

Authors:  B K Colasanti; E H Barany
Journal:  Invest Ophthalmol Vis Sci       Date:  1978-08       Impact factor: 4.799

10.  Effects of alpha-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig.

Authors:  G P Thomas; R M Tripathi
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739
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  1 in total

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Journal:  Br J Clin Pharmacol       Date:  2010-06       Impact factor: 4.335
  1 in total

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