Literature DB >> 33904010

Deep learning early warning system for embryo culture conditions and embryologist performance in the ART laboratory.

Charles L Bormann1, Carol Lynn Curchoe2, Prudhvi Thirumalaraju3, Manoj K Kanakasabapathy3, Raghav Gupta3, Rohan Pooniwala3, Hemanth Kandula3, Irene Souter1, Irene Dimitriadis1, Hadi Shafiee3.   

Abstract

Staff competency is a crucial component of the in vitro fertilization (IVF) laboratory quality management system because it impacts clinical outcomes and informs the key performance indicators (KPIs) used to continuously monitor and assess culture conditions. Contemporary quality control and assurance in the IVF lab can be automated (collect, store, retrieve, and analyze), to elevate quality control and assurance beyond the cursory monthly review. Here we demonstrate that statistical KPI monitoring systems for individual embryologist performance and culture conditions can be detected by artificial intelligence systems to provide systemic, early detection of adverse outcomes, and identify clinically relevant shifts in pregnancy rates, providing critical validation for two statistical process controls proposed in the Vienna Consensus Document; intracytoplasmic sperm injection (ICSI) fertilization rate and day 3 embryo quality.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  AI; Assisted reproductive technologies; CNN; Clinical decision-making; Competency; Convolutional neural network; Embryo quality; Embryology; Infertility, Artificial intelligence; Laboratory quality management systems; Proficiency; Quality assurance

Mesh:

Year:  2021        PMID: 33904010      PMCID: PMC8324654          DOI: 10.1007/s10815-021-02198-x

Source DB:  PubMed          Journal:  J Assist Reprod Genet        ISSN: 1058-0468            Impact factor:   3.357


  19 in total

1.  Selection of patients suitable for one-embryo transfer may reduce the rate of multiple births by half without impairment of overall birth rates.

Authors:  A Strandell; C Bergh; K Lundin
Journal:  Hum Reprod       Date:  2000-12       Impact factor: 6.918

2.  The application of quality systems in ART programs.

Authors:  M Wikland; C Sjöblom
Journal:  Mol Cell Endocrinol       Date:  2000-08-15       Impact factor: 4.102

Review 3.  Internal quality control and external quality assurance in the IVF laboratory.

Authors:  P L Matson
Journal:  Hum Reprod       Date:  1998-12       Impact factor: 6.918

4.  An artificial neural network for the prediction of assisted reproduction outcome.

Authors:  Paraskevi Vogiatzi; Abraham Pouliakis; Charalampos Siristatidis
Journal:  J Assist Reprod Genet       Date:  2019-06-19       Impact factor: 3.412

5.  Development and evaluation of inexpensive automated deep learning-based imaging systems for embryology.

Authors:  Manoj Kumar Kanakasabapathy; Prudhvi Thirumalaraju; Charles L Bormann; Hemanth Kandula; Irene Dimitriadis; Irene Souter; Vinish Yogesh; Sandeep Kota Sai Pavan; Divyank Yarravarapu; Raghav Gupta; Rohan Pooniwala; Hadi Shafiee
Journal:  Lab Chip       Date:  2019-11-22       Impact factor: 6.799

6.  Key performance indicators score (KPIs-score) based on clinical and laboratorial parameters can establish benchmarks for internal quality control in an ART program.

Authors:  José G Franco; Claudia G Petersen; Ana L Mauri; Laura D Vagnini; Adriana Renzi; Bruna Petersen; M C Mattila; Vanessa A Comar; Juliana Ricci; Felipe Dieamant; João Batista A Oliveira; Ricardo L R Baruffi
Journal:  JBRA Assist Reprod       Date:  2017-06-01

7.  The human factor: does the operator performing the embryo transfer significantly impact the cycle outcome?

Authors:  F Cirillo; P Patrizio; M Baccini; E Morenghi; C Ronchetti; L Cafaro; E Zannoni; A Baggiani; P E Levi-Setti
Journal:  Hum Reprod       Date:  2020-02-29       Impact factor: 6.918

8.  Evaluation of deep convolutional neural networks in classifying human embryo images based on their morphological quality.

Authors:  Prudhvi Thirumalaraju; Manoj Kumar Kanakasabapathy; Charles L Bormann; Raghav Gupta; Rohan Pooniwala; Hemanth Kandula; Irene Souter; Irene Dimitriadis; Hadi Shafiee
Journal:  Heliyon       Date:  2021-02-23

9.  Quality management systems for your in vitro fertilization clinic's laboratory: Why bother?

Authors:  Jan I Olofsson; Manish R Banker; Late Peter Sjoblom
Journal:  J Hum Reprod Sci       Date:  2013-01

10.  The impact of selected embryo culture conditions on ART treatment cycle outcomes: a UK national study.

Authors:  Catherine M Castillo; Joyce Harper; Stephen A Roberts; Helen C O'Neill; Edward D Johnstone; Daniel R Brison
Journal:  Hum Reprod Open       Date:  2020-02-10
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