Literature DB >> 3390185

Expression of proto-ret mRNA in embryonic and adult rat tissues.

T Tahira1, Y Ishizaka, T Sugimura, M Nagao.   

Abstract

The expression of proto-ret mRNA in adult and embryonic rat tissues were studied. Very low levels of proto-ret transcripts were found in adult rat tissues such as brain, thymus and testis. The sizes of these transcripts were almost the same as those found in human neuroblastoma, SK-N-SH cells. High levels of proto-ret transcripts were found in the rat conceptus on days 9 to 11 of gestation, but not at later stages of development. The level of transcripts in the conceptus on day 10 was about 20-50 times that in adult rat thymus. These results suggest that the proto-ret product, which is possibly a receptor-type tyrosine kinase, has special functions during embryonic development.

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Year:  1988        PMID： 3390185     DOI： 10.1016/s0006-291x(88)81368-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  A distinctive family of embryonic protein-tyrosine kinase receptors.

Authors:  E B Pasquale
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

2.  A newly identified RET proto-oncogene polymorphism is found in a high number of endocrine tumor patients.

Authors:  Wolfgang Gartner; Ivelina Mineva; Teodora Daneva; Sabina Baumgartner-Parzer; Bruno Niederle; Heinrich Vierhapper; Michael Weissel; Ludwig Wagner
Journal:  Hum Genet       Date:  2005-04-20       Impact factor: 4.132

3.  Flat reversion by okadaic acid of raf and ret-II transformants.

Authors:  R Sakai; I Ikeda; H Kitani; H Fujiki; F Takaku; U Rapp; T Sugimura; M Nagao
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

4.  Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.

Authors:  K M Carlson; S Dou; D Chi; N Scavarda; K Toshima; C E Jackson; S A Wells; P J Goodfellow; H Donis-Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

5.  DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration.

Authors:  K Yamashita; M Adachi; S Kato; H Nakagama; M Ochiai; K Wakabayashi; S Sato; M Nagao; T Sugimura
Journal:  Jpn J Cancer Res       Date:  1990-05

6.  Expression of ret proto-oncogene in human neuroblastomas.

Authors:  M Nagao; Y Ishizaka; A Nakagawara; K Kohno; M Kuwano; T Tahira; F Itoh; I Ikeda; T Sugimura
Journal:  Jpn J Cancer Res       Date:  1990-04

7.  Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line.

Authors:  Y Ishizaka; F Itoh; T Tahira; I Ikeda; T Ogura; T Sugimura; M Nagao
Journal:  Jpn J Cancer Res       Date:  1989-12
  7 in total

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