Literature DB >> 1694838

Expression of ret proto-oncogene in human neuroblastomas.

M Nagao1, Y Ishizaka, A Nakagawara, K Kohno, M Kuwano, T Tahira, F Itoh, I Ikeda, T Sugimura.   

Abstract

We examined the expression of ret proto-oncogene (proto-ret) in surgically resected human neuroblastomas. Slot blot RNA hybridization revealed that all 29 neuroblastomas examined expressed the proto-ret, the relative intensity of the hybridization ranging from 1 to 48. No correlation was found between the level of expression of proto-ret and the clinical stage. The level of expression was also not correlated with N-myc amplification, the patient's age or the histological type of the tumor. Based on the previous finding that proto-ret expression is very rarely detected in tumor cell lines other than those of neuroblastoma, proto-ret expression was suggested to be a characteristic of neuroblastomas, and possibly to be involved in the genesis of neuroblastomas.

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Year:  1990        PMID： 1694838      PMCID： PMC5918050          DOI： 10.1111/j.1349-7006.1990.tb02566.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  19 in total

1.  Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.

Authors:  T Tahira; Y Ishizaka; F Itoh; T Sugimura; M Nagao
Journal:  Oncogene       Date:  1990-01       Impact factor: 9.867

2.  ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

Authors:  M Takahashi; G M Cooper
Journal:  Mol Cell Biol       Date:  1987-04       Impact factor: 4.272

3.  Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

Authors:  S Nakajima-Iijima; H Hamada; P Reddy; T Kakunaga
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

4.  Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

Authors:  M Takahashi; Y Buma; T Iwamoto; Y Inaguma; H Ikeda; H Hiai
Journal:  Oncogene       Date:  1988-11       Impact factor: 9.867

5.  Establishment of tumor cell lines from a patient with head and neck cancer and their different sensitivities to anti-cancer agents.

Authors:  S Komiyama; K Matsui; S Kudoh; I Nogae; Y Kuratomi; Y Saburi; K Asoh; K Kohno; M Kuwano
Journal:  Cancer       Date:  1989-02-15       Impact factor: 6.860

6.  Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing.

Authors:  Y Ishizaka; M Ochiai; T Tahira; T Sugimura; M Nagao
Journal:  Oncogene       Date:  1989-06       Impact factor: 9.867

7.  Expression of proto-ret mRNA in embryonic and adult rat tissues.

Authors:  T Tahira; Y Ishizaka; T Sugimura; M Nagao
Journal:  Biochem Biophys Res Commun       Date:  1988-06-30       Impact factor: 3.575

8.  Molecular cloning and characterization of human ret-II oncogene.

Authors:  Y Ishizaka; T Tahira; M Ochiai; I Ikeda; T Sugimura; M Nagao
Journal:  Oncogene Res       Date:  1988-09

9.  High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma.

Authors:  I Bongarzone; M A Pierotti; N Monzini; P Mondellini; G Manenti; R Donghi; S Pilotti; M Grieco; M Santoro; A Fusco
Journal:  Oncogene       Date:  1989-12       Impact factor: 9.867

10.  Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.

Authors:  M Schwab; J Ellison; M Busch; W Rosenau; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205
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  11 in total

1.  RET proto-oncogene mutations and rearrangements in endocrine diseases.

Authors:  R V Lloyd
Journal:  Am J Pathol       Date:  1995-12       Impact factor: 4.307

2.  No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma.

Authors:  R M Hofstra; N C Cheng; C Hansen; R P Stulp; T Stelwagen; N Clausen; N Tommerup; H Caron; A Westerveld; R Versteeg; C H Buys
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

3.  Presymptomatic genetic screening in families with multiple endocrine neoplasia type 2.

Authors:  A Frilling; W Höppner; C Eng; L Mulligan; F Raue; C E Broelsch
Journal:  J Mol Med (Berl)       Date:  1995-05       Impact factor: 4.599

4.  Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.

Authors:  K M Carlson; S Dou; D Chi; N Scavarda; K Toshima; C E Jackson; S A Wells; P J Goodfellow; H Donis-Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

Review 5.  RET and neuroendocrine tumors.

Authors:  Yoshiki Murakumo; Mayumi Jijiwa; Naoya Asai; Masatoshi Ichihara; Masahide Takahashi
Journal:  Pituitary       Date:  2006       Impact factor: 3.599

6.  Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.

Authors:  T Iwamoto; M Takahashi; M Ito; K Hamatani; M Ohbayashi; W Wajjwalku; K Isobe; I Nakashima
Journal:  EMBO J       Date:  1991-11       Impact factor: 11.598

7.  Neuroblastoma in a transgenic mouse carrying a metallothionein/ret fusion gene.

Authors:  T Iwamoto; M Taniguchi; W Wajjwalku; I Nakashima; M Takahashi
Journal:  Br J Cancer       Date:  1993-03       Impact factor: 7.640

8.  Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma.

Authors:  Bradley D DeNardo; Michael P Holloway; Qinqin Ji; Kevin T Nguyen; Yan Cheng; Marcus B Valentine; Arthur Salomon; Rachel A Altura
Journal:  PLoS One       Date:  2013-12-11       Impact factor: 3.240

Review 9.  Cell Proliferation in Neuroblastoma.

Authors:  Laura L Stafman; Elizabeth A Beierle
Journal:  Cancers (Basel)       Date:  2016-01-12       Impact factor: 6.639

10.  A novel somatic point mutation of the RET Proto-oncogene in tumor tissues of small cell lung cancer patients.

Authors:  H Futami; S Egawa; T Tsukada; K Maruyama; S Bandoh; M Noguchi; K Yamaguchi
Journal:  Jpn J Cancer Res       Date:  1995-12
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