Koray Başdelioğlu1. 1. Istanbul Oncology Hospital Department of Orthopaedic and Traumatology, Istanbul, Turkey.
Abstract
BACKROUND: The present study aimed to determine the frequency of spinal metastases, to evaluate the features of spinal metastases, and to reveal clues to shed light on the origin of spinal metastases with unknown primary. METHODS: The data of patients who were followed up with the diagnosis of cancer in Istanbul Oncology Hospital between 2017 and 2019 were analyzed retrospectively. A total of 156 patients with spinal metastases and without visceral metastases were included in the study by applying inclusion and exclusion criteria. Clinical data, pathological diagnostic reports, and positron emission tomography-computed tomography results of 156 patients were evaluated. The groups were evaluated in terms of age, gender, number of spinal metastases (single focus, multiple focus), and localization of spinal metastasis. The spinal localization evaluation included both the main anatomical localizations and a detailed evaluation of each spine. RESULTS: The most common metastasis region was the thoracic spine in respiratory system cancers (28.38%), the thoracic + lumbar spine in breast (42.42%), prostate (50.00%), and gynecologic (40.00%) cancers, and the lumbar spine in gastrointestinal (37.50%) and urinary (30.00%) tract cancers (P = .313). C5 spinal metastasis percentages were significantly higher in breast and gastrointestinal tract cancers than the others (P = .042). T5 spinal metastasis percentage was significantly higher in gynecologic tumors than in the other cancers (P = .002). T10 spinal metastasis percentages were significantly higher in prostate and gynecologic tumors than the others (P = .016). L1 spinal metastasis percentage was significantly higher in breast tumors (P = .009). L2 spinal metastasis percentages were significantly higher in breast, prostate, and gynecologic tumors (P = .011). L4 spinal metastasis percentages were significantly higher in breast and prostate tumors (P = .041). L5 spinal metastasis percentage was significantly higher in prostate tumors (P = .029) than the other cancers. CONCLUSIONS: It was observed that primary cancers were often prone to metastasis to nearby spine. The results obtained by detailed examination of spinal metastases may provide a clinical benefit by providing clues in investigation of primary unknown cancers. LEVEL OF EVIDENCE: 3. This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery.
BACKROUND: The present study aimed to determine the frequency of spinal metastases, to evaluate the features of spinal metastases, and to reveal clues to shed light on the origin of spinal metastases with unknown primary. METHODS: The data of patients who were followed up with the diagnosis of cancer in Istanbul Oncology Hospital between 2017 and 2019 were analyzed retrospectively. A total of 156 patients with spinal metastases and without visceral metastases were included in the study by applying inclusion and exclusion criteria. Clinical data, pathological diagnostic reports, and positron emission tomography-computed tomography results of 156 patients were evaluated. The groups were evaluated in terms of age, gender, number of spinal metastases (single focus, multiple focus), and localization of spinal metastasis. The spinal localization evaluation included both the main anatomical localizations and a detailed evaluation of each spine. RESULTS: The most common metastasis region was the thoracic spine in respiratory system cancers (28.38%), the thoracic + lumbar spine in breast (42.42%), prostate (50.00%), and gynecologic (40.00%) cancers, and the lumbar spine in gastrointestinal (37.50%) and urinary (30.00%) tract cancers (P = .313). C5 spinal metastasis percentages were significantly higher in breast and gastrointestinal tract cancers than the others (P = .042). T5 spinal metastasis percentage was significantly higher in gynecologic tumors than in the other cancers (P = .002). T10 spinal metastasis percentages were significantly higher in prostate and gynecologic tumors than the others (P = .016). L1 spinal metastasis percentage was significantly higher in breast tumors (P = .009). L2 spinal metastasis percentages were significantly higher in breast, prostate, and gynecologic tumors (P = .011). L4 spinal metastasis percentages were significantly higher in breast and prostate tumors (P = .041). L5 spinal metastasis percentage was significantly higher in prostate tumors (P = .029) than the other cancers. CONCLUSIONS: It was observed that primary cancers were often prone to metastasis to nearby spine. The results obtained by detailed examination of spinal metastases may provide a clinical benefit by providing clues in investigation of primary unknown cancers. LEVEL OF EVIDENCE: 3. This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery.