Literature DB >> 3390078

Correlations between cis-platinum dosage and toxicity in a guinea pig model.

L J Hoeve1, I R Mertens zur Borg, M Rodenburg, M P Brocaar, B G Groen.   

Abstract

A guinea pig model was used to study correlations between cis-platinum dosage and level of hearing loss, hair cell loss in the cochlea. Other parameters measured included weight loss and serum urea, creatinine, and cis-platinum levels. The damage to the inner ear expressed as hearing loss and hair cell loss demonstrated a highly positive correlation with the dosage of cis-platinum, and only a moderately positive correlation with the cis-platinum serum levels. Weight loss correlated well with hearing loss.

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Year:  1988        PMID： 3390078     DOI： 10.1007/bf00481444

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  14 in total

1.  Effects of cis-diamminedichloroplatinum (NSC-119875) on hearing function in man.

Authors:  I J Piel; D Meyer; C P Perlia; V I Wolfe
Journal:  Cancer Chemother Rep       Date:  1974 Nov-Dec

2.  Increased tissue deposition and decreased excretion of platinum following administration of cisplatin to cisplatin-pretreated animals.

Authors:  C L Litterst; V G Schweitzer
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

3.  Pathophysiology of the ototoxicity of cis-diamminedichloroplatinum.

Authors:  S Komune; S Asakuma; J B Snow
Journal:  Otolaryngol Head Neck Surg       Date:  1981 Mar-Apr       Impact factor: 3.497

4.  Cis-diaminedichloro platinum ototoxicity. An experimental study.

Authors:  J Marco-Algarra; J Basterra; J Marco
Journal:  Acta Otolaryngol       Date:  1985 Mar-Apr       Impact factor: 1.494

5.  Analysis of hearing loss due to cis-diamminedichloroplatinum-II.

Authors:  L G van Zeijl; E A Conijn; M Rodenburg; R A Tange; M P Brocaar
Journal:  Arch Otorhinolaryngol       Date:  1984

6.  The metabolism of cis-dichlorodiammineplatinum (II): distribution, clearance, and toxicity.

Authors:  L D Lagasse; R G Pretorius; E S Petrilli; L C Ford; J Hoeschele; C Kean
Journal:  Am J Obstet Gynecol       Date:  1981-04-01       Impact factor: 8.661

7.  Ototoxicity in patients receiving cisplatin: importance of dose and method of drug administration.

Authors:  R R Reddel; R F Kefford; J M Grant; A S Coates; R M Fox; M H Tattersall
Journal:  Cancer Treat Rep       Date:  1982-01

8.  Cis-diamminedichloroplatinum (II) ototoxicity in the guinea pig.

Authors:  S A Estrem; R W Babin; J H Ryu; K C Moore
Journal:  Otolaryngol Head Neck Surg       Date:  1981 Jul-Aug       Impact factor: 3.497

9.  Development of cis-platinum-induced hearing loss in guinea pigs.

Authors:  L J Hoeve; E A Conijn; I R Mertens zur Borg; M Rodenburg
Journal:  Arch Otorhinolaryngol       Date:  1987

10.  Cisplatin nephrotoxicity. Correlation with plasma platinum concentrations.

Authors:  D P Kelsen; N Alcock; C W Young
Journal:  Am J Clin Oncol       Date:  1985-02       Impact factor: 2.339
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  2 in total

1.  Inhibition of adenylate-cyclase-coupled G protein complex by ototoxic diuretics and cis-platinum in the inner ear of the guinea pig.

Authors:  T Koch; B Gloddek
Journal:  Eur Arch Otorhinolaryngol       Date:  1991       Impact factor: 2.503

2.  Acute hyperpolarization and elongation of cochlear outer hair cells on superfusion with cis-platinum.

Authors:  A Ernst; H P Zenner
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503
  2 in total

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