Literature DB >> 7662351

Acute hyperpolarization and elongation of cochlear outer hair cells on superfusion with cis-platinum.

A Ernst1, H P Zenner.   

Abstract

The acute effects of cis-platinum on isolated cochlear outer hair cells (OHC) were investigated with whole-cell patch-clamps and measurements of cell length changes. Our findings demonstrated that cis-platinum reversibly induced a hyperpolarization and cellular elongation. These results suggest that the effects produced are the result of an interaction between cis-platinum and transduction channels in OHC. These acute effects are distinctly different from the chronic, irreversible ones that are followed by death of the OHC. The exact mechanism of these chronic effects remains unknown as yet.

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Year:  1995        PMID： 7662351     DOI： 10.1007/bf00178105

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  18 in total

1.  Interaction of cisplatin and noise on the peripheral auditory system.

Authors:  M A Gratton; R J Salvi; B A Kamen; S S Saunders
Journal:  Hear Res       Date:  1990-12       Impact factor: 3.208

Review 2.  Ion channels for the mechano-electrical transduction and efferent synapse of the hair cell.

Authors:  H Ohmori
Journal:  Adv Biophys       Date:  1992

3.  Membrane potential and ion channels in isolated outer hair cells of guinea pig cochlea.

Authors:  A H Gitter; H P Zenner; E Frömter
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  1986       Impact factor: 1.538

4.  Outer hair cells as fast and slow cochlear amplifiers with a bidirectional transduction cycle.

Authors:  H P Zenner; W Arnold; A H Gitter
Journal:  Acta Otolaryngol       Date:  1988 May-Jun       Impact factor: 1.494

5.  Sound preprocessing by ac and dc movements of cochlear outer hair cells.

Authors:  H P Zenner; A Ernst
Journal:  Prog Brain Res       Date:  1993       Impact factor: 2.453

6.  Acute gentamicin ototoxicity in cochlear outer hair cells of the guinea pig.

Authors:  A Ernst; G Reuter; U Zimmermann; H P Zenner
Journal:  Brain Res       Date:  1994-02-04       Impact factor: 3.252

7.  Ototoxicity of cis-dichlorodiammine platinum (II) in guinea pigs.

Authors:  T Konishi; B N Gupta; J Prazma
Journal:  Am J Otolaryngol       Date:  1983 Jan-Feb       Impact factor: 1.808

8.  Effect of cisplatin on hair cell morphology and lateral wall Na,K-ATPase activity.

Authors:  S E Barron; E A Daigneault
Journal:  Hear Res       Date:  1987       Impact factor: 3.208

9.  Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA.

Authors:  A Eastman
Journal:  Biochemistry       Date:  1986-07-01       Impact factor: 3.162

10.  Early effects of gentamicin on inner ear glycocalyx cytochemistry.

Authors:  J C de Groot; J E Veldman
Journal:  Hear Res       Date:  1988-09-01       Impact factor: 3.208
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