Age and gender differences in the prevalence of chronic diseases and atherosclerotic cardiovascular disease risk scores in adults in Riyadh city, Saudi Arabia.

OBJECTIVES: To evaluate age and gender differences in the prevalence of chronic diseases and to calculate atherosclerotic cardiovascular disease (ASCVD) risk scores in adults aged 30-75 years in Riyadh city, Saudi Arabia.
METHODS: This cross-sectional, interview-based study was conducted with 2997 men and women, visiting primary health care centers in Riyadh, during the years 2015 to 2016. Serum glycosylated hemoglobin and lipid levels were measured by ion-exchange high-performance liquid chromatography and fully automated analyzer using enzymatic methods, respectively. The 10-year and lifetime ASCVD risk scores were calculated using an online calculator.
RESULTS: The mean age of men was 43.1 (±11.7) and women was 43.8 (± 10.9) years. Prevalence rates of diabetes mellitus, hypertension, hypercholesterolemia, and obesity in men versus women were 20.3% versus 24.8% (p=0.006), 15% versus 19.5% (p=0.003), 50.7% versus 53.4% (p=0.16), and 41.2% versus 56.7% (p<0.001), respectively. Majority of men and women with chronic diseases belonged to the age groups 30-39 and 50-59 years, respectively. High 10-year ASCVD risk was found in 32% men and 7.6% women, whereas lifetime risk was present in 67% and 51%, respectively.
CONCLUSION: Women in the age group 50-59 years, with multiple risk factors are at a greater risk of developing cardiovascular diseases than men of same age. Young adults were at more risk for lifetime ASCVD, whereas the 10-year ASCVD risk increased with increasing age. Copyright: © Saudi Medical Journal.

Non-communicable diseases (NCDs) are a global public health problem, which includes cardiovascular diseases (CVDs), diabetes mellitus (DM), obesity, lipid disorders, and respiratory and musculoskeletal diseases.[1] It has been reported that the total number of NCD-related deaths accounted for 73.4% of global causes of deaths and had increased by 22.7% from the year 2007-2017, primarily due to CVDs.[1] Non-communicable diseases are responsible for 78% of all deaths in the Kingdom of Saudi Arabia (KSA), with 46% being CVD-related deaths.[2] The increasing trend in non-communicable diseases in KSA is associated with increase in disability and negative impact on quality of life.[3] In the United States, the number of deaths attributed to CVDs accounted for 33% of all-cause mortality occurring in the younger adult population aged <75 years in 2008.[4] In 2015, CVD was reported as the topmost leading cause of mortality, with a death rate of 43.8%, and by the year 2035, the medical cost has been estimated to reach $368 billion.[5]

In the Saudi national-level survey conducted during 2007-2009, Al-Rubeaan reported that the prevalence rates of metabolic syndrome were 31.6% (34.4% in men versus 29.2% in women) according to the International Diabetes Foundation (IDF)and 39.9% (45% in men versus 35.4% in women) in National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III) criteria.[6] The Centralized Pan-Middle East Survey (CEPHEUS) on the under treatment of hypercholesterolemia in 2010 in the Arabian Gulf also reported the presence of obesity with a prevalence rate of 53%, DM 76%, metabolic syndrome 41%, hypertension (HTN) 70%, and smoking 13%. Approximately 78% of CEPHEUS participants had very high atherosclerotic cardiovascular disease (ASCVD) risk status with 3 or more major risk factors, with 75% of Saudis (2449/3259) belonging to the very high ASCVD risk status.[7] It was estimated that by controlling the major risk factors, including smoking, alcohol consumption, salt intake, obesity, and high blood pressure and glucose levels, the NCD-related premature mortality (death between 30 and 70 years of age) over 15 years, during 2010-2025, can be reduced by 22% in men and 19% in women.[8] In addition to body mass index (BMI), central obesity, based on waist circumference, is a reliable indicator for predicting CVD risk.[9] Study from KSA have found that 2 or more than 2 risk factors for metabolic syndrome were higher among men (46.8%) compared to women (40.5). The study also found that waist circumference cut-offs values (92 cms for men, and 87 cms for women) were better than waist-hip ratio and the BMI in predicting metabolic syndrome in the local population.[10]

Atherosclerotic cardiovascular diseases are considered as the leading cause of mortality among women due to gender-specific risk factors such as menarche, menopause, parity, and pregnancy-related diseases, and approximately 40% of them have a lifetime risk of developing ASCVDs after age 50 years.[11] To estimate the lifetime risk of developing ASCVDs, a study conducted on 8000 cohort population of the Framingham study group who were free of CVD and aged 50 years reported an estimated lifetime risk of 51.7% for men and 39.2% for women.[12] The lifetime risk increased in the presence of one or more risk factors.[12] Another study conducted on a cohort population of South Asian origin estimated the lifetime risk of developing ASCVDs as 79% for men and 70% for women, with the 10-year estimated risk of 12.6% for men and 5.1% for women.[13] In the KSA, the pattern of NCD has changed since the past 2 decades due to changes in the Saudi living standards. There has been a tremendous increase in tobacco use, physical inactivity, and obesity among men and women.[3] The incidence and prevalence of a disease are core indicators of public health, which guide in deciding upon issues such as which diseases are most common and what health problems warrant priority.[1,2] Therefore, this study was conducted to determine the prevalence of chronic diseases, including DM, HTN, hypercholesterolemia, and obesity, according to age and gender and also to estimate the 10-year and lifetime ASCVD risk scores among Saudi men and women aged 30-75 yeas in Riyadh city, Saudi Arabia.

Methods

This study was conducted in 18 randomly (https://www.random.org/) selected primary health care centers belonging to 5 administrative regions in Riyadh city, 2015-2016. According to the KSA population statistics, 218,000 people were living in Riyadh during the study period. The study was well-advertised in the vicinity of the PHCC, so that maximum number can participate. Posters and banners were placed at all major places, like malls, mosques, schools, and so forth. Patients and their attendants visiting the PHCC were invited to participate in the study. The daytime data collection was colliding with offices timings; therefore, data collectors separately visited private offices and educational institutes so to include the working population.

The inclusion criteria were all Saudi adults aged between 30 and 75 years who were permanent residents of Riyadh city. The response rate was encouraging, with <5% refusal rate.[17] Forms were discarded due to incomplete information and 2997 participants were included in the final analysis. Blood samples for analyzing the lipid profile and glycosylated hemoglobin (HbA1c) levels were collected according to the standard protocol, and laboratory analysis was conducted at King Khalid University Hospital, Riyadh, KSA.

The study was conducted according to the principles of Helsinki Declaration. The study protocol was approved by the Institutional Review Board, King Saud University (E-12-658) and the Institutional Review Board of the Ministry of Health, KSA (IRB ID MOH0151). A written informed consent was obtained from participants after explaining the purpose of the study with emphasis on voluntary participation, anonymity, and confidentiality.

Anthropometric and blood pressure measurements.

The anthropometric indices included weight, which was measured using an electronic scale (Secca 220, Hamburg, Germany, 2009), and height, which was measured using the standard method with a stadiometer. Body mass index was calculated by using the formula weight in kilograms/height in square meters. Waist circumference (WC) was used to determine the central obesity. It was measured using a measuring tape at the midpoint between the lowest rib and the top of the hip bone (iliac crest). Central obesity for men and women was defined as a WC of >90 and >80 cm, respectively, and high central obesity was defined as >102 and >88 cm, respectively.[14] Two blood pressure readings were taken using the oscillometric method with the participant in an upright position, according to the instruction manual (Omron-5 Series TM Blood Pressure Monitor Model BP742-China 2010). The average of both readings was computed.

Measurement of HbA1c level

Hemoglobin A1c level was measured at the central laboratory of King Khalid University Hospital by the ion-exchange high-performance liquid chromatography (HPLC) method using Tosoh G8 -90SL or the Tosoh G8 HPLC Analyzer (Tosoh Bioscience, Inc, USA). The coefficient of variation (CV) was <2%. Two HbA1c cut-off points were taken for patients with previously physician-diagnosed DM, the control HbA1C level was taken as ≤7%, and for those with newly diagnosed DM, the HbA1C level was taken as ≤6.5%.

Measurement of lipids

Serum levels of total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL)-cholesterol, and triglycerides (TGs) were measured in millimoles per liter using a fully automated analyzer (Siemens Dimension RxL, Germany) using enzymatic methods. The intra-assay and inter-assay CVs were 0.84 and 1.30 for total cholesterol and 1.9 and 2.1 for HDL-cholesterol, respectively. The respective intra-assay and inter-assay CVs were 0.84 and 1.30 for total cholesterol, 1.9 and 2.1 for HDL, and 0.4 and 1.0 for TGs. low density lipoprotein-cholesterol was calculated using the Friedewald equation:

Atherosclerotic cardiovascular diseases risk scores

The ASCVD include patients with a history of acute coronary syndrome, myocardial infarction, stable angina, coronary/other arterial revascularization, stroke, transient ischemic attack, or peripheral arterial disease from atherosclerosis.[16] The online calculation requires information regarding age, gender, race, systolic blood pressure (at the time of the interview), treatment for HTN (yes/no), diabetes (yes/no), smoking (yes/no), total blood cholesterol, and HDL levels for each participant.[16]

Statistical analysis

The data were analyzed using Statistical Package for Social Sciences (SPSS)® version 21) Armonk, NY. IBM Corp. USA. Descriptive statistics consisting of frequency percentages for categorical variables and mean with standard deviation for continuous variables were calculated. Pearson Chi-square test was utilized to measure the difference in categorical variables.Bivariate analysis was conducted to calculate the unadjusted odds ratio and 95% confidence interval (CI) between gender and chronic diseases. The lifetime and 10-year ASCVD risk scores were calculated according to the free online program available at https://tools.acc.org/ldl/ascvd_risk_estimator/index.html#!/calulate/estimator/. The ASCVD risk score calculator measures the lifetime and 10-year risk scores. The lifetime risk score calculates ASCVD scores for individuals aged 20-59 years and was divided into 2 categories based on less than or ≥39% risk estimate. The 10-year ASCVD risk score was calculated for individuals aged 40-75 years, with a cut-off value of 7.5 to identify high risk individuals.[14] The level of statistical significance was set as p<0.05.

Results

Table 1 shows the sociodemographic profile of the 2997 participants, comprising of 968 men, and 2029 women. There was no significant difference in the mean age of men (43.1 ±11.7) and women (43.8 ±10.9) years (p=0.07). Approximately 65% (n=149) of men reported smoking for >10 years, whereas women, although few, had a more recent history of smoking. Most men (n=120) were smoking ≥20 cigarettes per day, whereas 30% of them were past smokers and had quit smoking.

Table 1

- Sociodemographic characteristics and anthropometric measurements of Saudi males and females in Riyadh city, Saudi Arabia.

Characteristics	Males (n=968)	Females (n=2029)	P-value
Age (years)			<0.07
30- 39	435 (44.9)	838 (41.3)
40- 49	275 (28.4)	577 (28.4)
50- 59	151 (15.6)	392 (19.3)
60- 75	107 (11.1)	222 (10.9)
Participants education			<0.01
Secondary & below	254 (26.2)	1153 (56.8)
University & above	714 (73.8)	876 (43.2)
Spouse education (n=2749)			<0.01
Intermediate & below	392 (45.3)	1122 (59.6)
University & above	474 (54.7)	761 (40.4)
Participants occupation			<0.01
Working	852 (88.0)	858 (42.3)
Not working	116 (12.0)	1171 (57.7)
Spouse occupation (n=2749)			<0.01
Working	632 (73.0)	1322 (70.2)
Not working	234 (27.0)	561 (29.8)
Housing type			<0.01
Traditional Arabic house	51 (5.3)	273 (13.5)
Apartment	341 (35.2)	474 23.4)
Villa	576 (59.5)	1280 (63.1)
Monthly income SAR (n=2661)			<0.01
≤10,000	320 (33.9)	986 (57.4)
>10,000	623 (66.1)	732 (42.6)
Current smoker			<0.01
Yes	268 (27.7)	44 (2.2)
No	700 (72.3)	1985 (97.8)

P-values calculated to measure significant difference between men and women using the Chi-square test

Diabetes mellitus. Differences in prevalence by age and gender

The overall prevalence of DM (physician diagnosed and on screening) was 23.4% (n=692), with women showing a higher prevalence than men (Table 2). Out of the 20% cases with physician diagnosed cases, 11% were showing uncontrolled diabetes (HbA1c levels >7%,). A small percentage (3%) of cases were identified as diabetic on screening (based on HbA1c levels >6.5%). The unadjusted odds ratio for total prevalence (diagnosed and on screening) revealed that women were 1.30 (1.16, 1.56; p=0.006) times at higher odds for having diabetes. Figure 1 shows that majority of diabetic men (30.3%) were in the age bracket of 40-49 years, whereas most women (35.4%) belonged to age group 50-59 years. A significant percentage (20.5%, n=474) of participants were found with prediabetes (HbA1c level 5.7%-6.4%), with a greater number of men than women (22.7% versus 19.9%). In contrast to diabetics, the majority of prediabetics belonged to the age group of 30-39 years (men 39% versus women 30%, p=0.04).

Table 2

- Prevalence of chronic diseases (diagnosed and screened)a in Saudi males and females in Riyadh city, Saudi Arabia.

Disease	Diagnosed and screened			Total prevalence
Diabetes mellitus	Diagnosed casesb Males =162, Females=438		Raised HbA1c on screening (≥6.5)	Total prevalencec (N=2962) (both diagnosed and screened) Males=961, Females=2001
	Controlled HbA1c ≤7.0	Uncontrolled HbA1c >7.0
Male	70 (7.3)	92 (9.6)	33 (4.1)		195 (20.3)
Female	203 (10.1)	235 (11.8)	59 (2.9)		497 (24.8)*
Total	273 (9.3)	327 (11.0)	92 (3.1)	692 (23.4)
Hypertension	Diagnosed casesbMales= 145, Females= 396		Raised blood pressure reading on screening only > 140 or/and > 90	Total prevalencec (N=2987) (only physician diagnosed) Males=968,Females=2029 Total=2987
	Controlled <140 and <90	Uncontrolled≥ 140 or/and ≥ 90
Males	63 (6.5)	82 (8.5)	134 (16.3)	145 (15.0)
Females	225(11.1)	171 (8.4)**	148 (9.1)	396 (19.5)
Total	288 (9.6)	253 (8.4)	282 (11.5)	541 (18.1)
Hypercholesterolemia	Diagnose d casesb Males= 174, Females= 516		Raised cholesterol levels on screening ≥5.2 mmol/L	Total prevalencec (N=2985) (both diagnosed & screened) Males=965, Females=2020
	Controlled <5.2 mmol/L	Uncontrolled ≥5.2 mmol/L
Males	98 (10.1)	76 (7.9)	315 (32.6)	489 (50.7)
Females	236 (11.6)	280 (13.9)***	563 (27.9)	1079 (53.4)
Total	334 (11.1)	356 (11.9)	878 (29.4)	1568 (52.5)
Body mass index ‡	Overweightb BMI ≥25.0 - ≤29.99		Obesityb BMI ≥30	Total prevalencec (N=2997) Males = 968, Females = 2029
Male	363 (37.5)		399 (41.2)	762 (78.7)
Female	587 (28.9)		1149 (56.7)§	1739 (85.7)
Total	950 (31.7)		1548 (51.7)	2504 (83.6)
Waist circumference	Central obesityb Male >90 - <102 cms, Female >80 - <88 cms		High central obesityb Male >102cms, Female >88cms	Total prevalencec (N=2997) Males = 968, Females = 2029
Male	256 (26.4)		286 (29.5)	542 (56)
Female	435 (21.4)‡		1252 (61.7)†	1687 (83.1)
Total	691 (23.0)		1538 (51.3)	2229 (74.4)

Diagnosed cases were physician diagnosed and those identified on screened were identified on conducting blood tests, bRow percentage cColumn percentage, dMissing data: DM males=7 and females=28; High cholesterol males= 3 and females = 8; Hypertriglyceridemia males=12 and females=30, p-values calculated using the Chi square test, *Total prevalence of diabetes mellitus in females compared to males: odds ratio (95%CI)=1.30 (1.16, 1.56), p=0.006, **Uncontrolled cases of hypertension in females compared to males: odds ratio (95%CI) = 0.57 (0.39, 0.84), p=0.004, ***Uncontrolled cases of hypercholesterolemia in females compared to males: odds ratio (95%CI) = 1.60 (1.12, 2.25),p=0.008, §Prevalence of obesity (BMI ≥30) in females compared to males: odds ratio (95% CI) = 2.02 (1.63, 2.50), p<0.001, ‡Prevalence of central obesity in females compared to males: odds ratio (95% CI) = 2.12 (1.72, 2.61), p<0.001, †Prevalence of high central obesity in females compared to males: odds ratio (95% CI)= 5.45 (4.50, 6.60), p<0.001

Figure 1

- Prevalence of diabetes mellitus in Saudi men and women by age categories in Riyadh city, Saudi Arabia.

Overall, 57.7% (n=1730) of participants had a positive family history of DM. The mean duration with DM was 8.86 (±7.4) years, with a range of 1-45 years. Although women had a higher prevalence of DM and positive family history, 8% of them were not taking any treatment (versus 4% men).

Hypertension. Differences in prevalence by age and gender

The overall prevalence of physician diagnosed HTN was lower than that of DM (18.1% versus 23.4%), with women showing better control than men [UOR 0.57 (0.39, 0.84) p<0.004] (Table 2). More men were detected with HTN as compared to women (16.3% versus 9.1%). Age distribution found that HTN in men was more common in the age group of 40-49 years (28%), whereas, in women, the number peaked between ages 50-59 years (33%). Pre-HTN was almost twice among men than that in women (42.9% men versus 21.2% women). Higher number of women reported positive family history (57% versus 40%) and average number of years with HTN [8.3 (±7.1) versus 6.4 (±6.1)] as compared to men.

Hypercholesterolemia. Differences in prevalence by age and gender

The overall prevalence of hypercholesterolemia was approximately 50%, with no significant difference between men and women (p=0.16) (Table 2). Among the diagnosed cases, the percentage of women with high cholesterol exceeded that of men (14% versus 8%), whereas, on screening it was opposite with more number of men than women (32.6% versus 27.9%). Age distribution found that amongst men 70% were aged 30-49 years, whereas, amongst 50-75 years, the proportion of women exceeded that of men (25.6% versus 16.6%). Positive family history (men 18.5% versus women 36.5%) and duration with hypercholesterolemia [men 4.3 (±4.2) versus women 5.7 (±5.2) years] were reported more by women in comparison to men. Amongst, physician-diagnosed cases, approximately 13% of participants were not taking any treatment (no significant gender difference, p=0.15).

Triglycerides and HDL-cholesterol levels

More men had elevated TG levels in comparison to women (48.6% vs 29.1%). Regarding age distribution, a higher proportion of men were aged 30–39 years (46.7% versus 33.4%), whereas 24.7% of women were in age group 50-59 years compared to 14.6% of men (p<0.001). A significantly high percentage of men had low HDL levels in comparison to women. (30% versus 8.5%). The age distribution followed the same trend as for other markers, with more men in the age group 30-39 years, whereas the proportion of women was higher in the age group 40-49 years (27% women versus 12% men) (p<0.001).

Differences in overweight and obesity by age and gender

Anthropometric measurements revealed that overweight was more common among men (37.5% versus 28.9%), whereas obesity was more common among women (41.2% versus 56.7%), respectively, with 9% of them suffering from extreme obesity (BMI ≥40 kg/m[2]). Waist circumference measurements showed that high central obesity was more common among women than among men (29.5% men versus 61.7% women) (Table 2). Overweight was more common among the young age categories in both men and women, although the difference was not statistically significant (p=0.22). Figure 2 shows the that obese men are more in number in the age category of 30-39 as compared to women, and it is vice versa for the age category 50-59 years. However, this difference was not statistically significantly different (p=0.10). However, age distribution for central obesity (men ≥90, women ≥80 cms) found no significant difference in proportion of men and women by age.

Figure 2

- Prevalence of central obesity in Saudi men and women by age categories in Riyadh city, Saudi Arabia.

Lifetime and 10-year ASCVD risk scores

The lifetime ASCVD risk scores were calculated for 1918 study participants (639 men and 1279 women) aged 30-59 years, whereas the 10-year ASCVD risk scores were calculated for 964 participants (324 men and 640 women) aged 40-75 years. The lifetime ASCVD risk score found that 56% (n=1081) of participants belonging to 30-59 years had high risk (>39%). The proportion of men with high lifetime risk is more compared to women (p<0.001) (Table 3). Regarding age distribution, almost 50% of men and women with high-risk scores belonged to the age group 30-39 years; however, specifically in the age group 50-59 years, the proportion of women exceeded that of men. The 10-year ASCVD risk scores found that 16% (n=153) of participants in the age group 40-75 years have high risk. The risk was significantly low in women (p<0.001); however, the age comparison revealed a greater number of women with high risk in the age group 60-75 years.

Table 3

- Proportion of Saudi men and women with high 10-year and lifetime atherosclerotic cardiovascular disease (ASCVD) risk scores by age category in Riyadh city, Saudi Arabia.

ASCVD risk	Age in years
	Males	Females	Total
Ten year ASCVD riska (>7.5) males=324, females=640 (n=964)	104 (32.1)	49 (7.6)	153 (15.9)*
Age (years)
40-49	6 (12.2)	3 (6.1)	40 (81.6)
50-59	35 (33.7)	20 (19.2)	49 (47.1)
60-75	41 (26.8)	23 (15.0)	89 (58.2)
Odds ratio between gender and 10 year ASCVD risk scores	5.70 (3.93, 8.28)
Lifetime ASCVD riskb (>39%)males=639, females=1279 (n=1918)	430 (67.3)	651 (50.9)	1081 (56.4)
Age (years)
30-39	238 (36.6)	284 (43.6)	129 (19.8)
40-49	143 (33.3)	226 (52.6)	61 (14.2)
50-59	381 (35.2)	510 (47.2)	190 (17.6)
Odds ratio between gender and lifetime ASCVD risk scores	1.98 (1.63, 2.42)

Values are presented as number and percentage (%), P-values calculated using the Chi-square test;

ASCVD 10-years risk difference between gender and age p<0.001,

ASCVD lifetime risk difference between gender and age p=0.007

Diabetes mellitus and HTN were the primary factors contributing toward high ASCVD risk scores. Among the 16% (n=153) with high 10-year ASCVD risk, 44% of men and 71% of women had DM. Furthermore, among these individuals, 40% (62 out of 153) had uncontrolled diabetes (HbA1c >6.5%). Similarly, for HTN, 25% (n=38) had uncontrolled blood pressure (>140/>90 mm Hg), without any significant gender difference. The high-risk lifetime ASCVD group showed that 13.5% (146 of 1081) had HbA1c >6.5%, whereas 12% of participants had uncontrolled HTN.

Table 4 shows the number of ASCVD risk factors by age categories. Many women (65.5%) had one risk factor, whereas 38% of men had minimum 2 risk factors. The number of men with maximum risk factors belonged to the age group 30-39 years, whereas, in the remaining age groups (40-75 years), the number of women exceeded that of men (Table 4).

Table 4

- Proportion of Saudi men and women with number of risk factors by age in Riyadh city, Saudi Arabia.

Number of risk factors by age*	Gender	Age in categories n (%)				Total (N=2032)Males=690 Females=1342
		30-39	40-49	50-59	60-75
1	Males	152 (59)	59 (23)	38 (15)	8 (3)	257 (40.3)
	Females	352 (55)	206 (32)	71 (11)	10 (2)	639 (65.5)
2	Males	127 (53)	68 (28)	30 (12)	17 (7)	242 (37.9)
	Females	84 (36)	80 (35)	39 (17)	28 (12)	231 (23.7)
3	Males	48 (42)	38 (33)	13 (11)	16 (14)	115 (18)
	Females	9 (12)	24 (31)	32 (42)*	12 (15)	77 (7.9)
4	Males	9 (37)	6 (25)	4 (17)	5 (21)	24 (3.8)
	Females	1 (4)	10 (36)	8 (28)	9 (32)	28 (2.9)

Key for risk factors include age, gender, systolic blood pressure (at the time of the interview), treatment for hypertension (yes/no), diabetes (yes/no), smoking (yes/no), total blood cholesterol, high-density lipoprotein (HDL), 1: p=0.02, 2 p=0.004, 3: p<0.001, 4: p=0.02,

Discussion

In the high- and middle-income countries of the Middle East, there has been a rapid economic development leading to an increasing rate of DM from approximately 6% in 1990 to >20% in 2012.[17] In the KSA, conducted during 2007-2009, Al-Rubeaan et al, reported that the overall prevalence of DM among the Saudi population aged ≥30 years was 25.4% (n=4576), with 12% (1845 of 15,303) being unaware of their disease.[18] Although, the estimated prevalence of undiagnosed DM is considered to be far lower at 3.1% a systematic review found that there is further need for creating awareness about diabetes by integrating awareness campaigns in the main health systems.[19] The epidemic behavior of DM prevalence in KSA might be explained primarily by ethnicity and genetic factors, accompanied by high consanguineous marriage rates.[20] In general, there is a wide gender ratio difference across countries with regard to DM prevalence, and different biological, cultural, lifestyle, environmental, and socioeconomic factors have their impact on the predisposition, development, and clinical presentation of DM.[21] Recently, the male gender has been considered as a risk factor for type 2 diabetes developments, with unclear reasons.[22] Moreover, the majority of data from Western European or Asian descent populations suggest a slightly higher prevalence of type 2 diabetes among men than among women.[23,24] In contrast to these results, the present study results demonstrated that DM prevalence is higher among women than among men. Such difference might be explained by having a higher obesity prevalence and more prone metabolic imbalance in women, in addition to a sedentary lifestyle.[24] Review studies conducted on prevalence and risk factors of chronic diseases among women belonging to Gulf countries, reported that a significant increase in the prevalence of DM was observed after the year 2000, and found no significant gender difference pertaining to DM prevalence[25,26]

The estimated HTN prevalence in the present study was 18%, with more women than men. Such prevalence is lower than that in a community-based local study published in 2007 at KSA, at 26.1% among people aged 30-70 years.[27] However, in another study published in 2014, the prevalence rates of HTN and borderline HTN among Saudi individuals aged ≥15 years were 15.2% and 40.6%, respectively.[28] Methodological differences might explain the difference in the prevalence reported by above studies. The highest percentage of hypertensive Saudis in the present study were undiagnosed, and the largest proportion of those on treatment were not controlled, a finding consistent with that of El Bcheraoui et al.[28] In contrast to previous studies, the prevalence of HTN was higher in women in the present study. A higher prevalence of HTN, diagnosed or undiagnosed, among men was also reported by Hanna et al in Panama.[29] These gender differences in HTN prevalence are due to both biological and behavioral factors.[30] Biological factors include sex hormones, chromosomal differences, and other biological gender differences that are protective against HTN.[30] It is worthy to mention here that such biological factors become evident during adolescence and persist through adulthood until women reach menopause, and at that point, the gender differences in HTN become smaller or even nonexistent, which might explain our finding that the peak of HTN prevalence was at age 50 years in women.

A complex difference exists between men and women in these key behavioral risk factors.[31] Body mass index distribution varies by gender, and as in our findings, previous studies have found that women have a higher prevalence of obesity than men, especially high-grade obesity, and in contrast, men have a higher prevalence of overweight than women.[32] In general, our data revealed that the overall prevalence of both overweight (31.7%) and obesity (51.7%) was extremely high at 83.6%, being higher among women at 85.7% than among men at 78.7%. Such prevalence is considered to be within the reported numbers in the Gulf Cooperation Council countries.[33] It has been estimated that the prevalence of overweight ranges between 25% and 50% and the prevalence of obesity ranges between 10% and 50% and is found to be relatively higher in women showing an increase with age.[33] Genetic predisposition, lack of outdoor physical exercise, and unhealthy lifestyle and dietary habits may play a role in this increasing metabolic illness, particularly in women.[34,35] A recent conceptual model on global obesity has placed the Middle East, including Saudi Arabia, in stage 2 of obesity transition. According to the authors, in stage 2, the prevalence is high among adults and the gender and socioeconomic differences are narrowed for women.[36] The transition stages can help policy makers identify the stage in which their country lies and make policy guidelines accordingly. Our study findings are in support of a previous study that found significant gender differences, with a greater number of women than men showing hypercholesterolemia.[35] Moreover, al-Nuaim et al found that there was a progressive increase in hypercholesterolemia with age, reaching a maximum in the fifth and sixth decades for men and women, respectively.[37]

In the US, ASCVDs remain the leading cause of death, accounting for 31.3% of all deaths.[38] Unfortunately, more than half of the present study participants had high lifetime ASCVD risk, and this is expected based on the high rates of CVD risk factors (obesity, diabetes, HTN, and hypercholesterolemia) reported in the study. Our results also demonstrated that overall, men have an increased risk for ASCVD than women, and that among men, the risk was higher at a younger age, which is consistent with a previously published study reporting that age and gender are independent and potential risk factors for CVD in adults.[39,40] It is reported that male gender and age are the strongest risk factors for coronary artery disease (CAD).[40] Gender differences in ASCVD risks are largely attributed to sex hormones and their associated receptors, where a protective effect of sex steroid hormones, particularly estrogen, on CVD risk in women has often been suggested.[41,42] Men generally develop CVD at a younger age and have a higher propensity of developing coronary heart disease than women, whereas women are at a higher risk of developing stroke, which often occurs at an older age.[42] In contrast, the effects of exogenous estrogen on the risk of developing ASCVDs in postmenopausal women were not beneficial and suggested that supplementation could even increase the risk for stroke among women with a history of CVD.[43] However, in another study, Rossouw demonstrated that estrogen could protect against CHD but not stroke among women within 5 years of menopause.[44] Based on the conception that women are “protected” against CVDs, the risk for heart disease in women is often underestimated.

In general, women with clinically manifesting CHD are older than men, with a higher expression of cardiovascular risk factors.[45] After menopause, central obesity with an increase in visceral fat occurs more frequently, with increased metabolic syndrome components in women compared with aging men.[40] Previous studies have reported a steep rise in systolic blood pressure in aging women compared with men, and authors had related it to the decline in estrogen levels during menopause transition.[42] Moreover, it was found that the relative risk for hypercholesterolemia is lower in women than men at a younger age, whereas in menopause, the total cholesterol and LDL levels increases significantly.[44]

Study limitations

The results of our study are robust as the sample represents the capital city, Riyadh, comprising of different ethnicities, social classes, and working population. Moreover, blood samples were transported and tested as per standard protocols. However, we are limited in generalizing the results to the rural areas. High-risk patients like patients with a history of myocardial infarction, previous PCI, or CABG may be underrepresented in this study, as such patients will have a follow-up in tertiary care centers and not in primary health care centers.

More effort should be directed toward the prevention and early detection of chronic diseases among women aged 50-59 years. Strategies to increase awareness and reduce the burden of CVD through multiple interventional programs should be implemented targeting obesity, tobacco use, physical inactivity, diet, and screening for chronic diseases such as DM, hypercholesterolemia, and CVDs.

In conclusion, chronic diseases were prevalent among both men and women, with men aged >30 years being at high risk, whereas the risk in women tended to increase from age 40 years but reached the peak at age >50 years. Women in the age group 50-59 years with multiple risk factors are at more risk of developing CVDs than men of same age. Obesity was more prevalent in women than men. A similar trend was observed for lifetime ASCVD scores; however, the 10-year ASCVD risk increased with increasing age.