Literature DB >> 33895328

Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy.

Jing Ruan1, Xiaomin Miao2, Dirk Schlüter3, Li Lin4, Xu Wang5.   

Abstract

Extracellular vesicles (EVs) are bilayer membrane vesicles and act as key messengers in intercellular communication. EVs can be secreted by both neurons and glial cells in the central nervous system (CNS). Under physiological conditions, EVs contribute to CNS homeostasis by facilitating omnidirectional communication among CNS cell populations. In response to CNS injury, EVs mediate neuroinflammatory responses and regulate tissue damage and repair, thereby influencing the pathogenesis, development, and/or recovery of neuroinflammatory diseases, including CNS autoimmune diseases, neurodegenerative diseases, stroke, CNS traumatic injury, and CNS infectious diseases. The unique ability of EVs to pass through the blood-brain barrier further confers them an important role in the bidirectional communication between the CNS and periphery, and application of EVs enables the diagnosis, prognosis, and therapy of neuroinflammatory diseases in a minimally invasive manner.
Copyright © 2021 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CNS diseases; diagnosis; extracellular vesicles; neuroinflammation; therapy

Mesh：

Substances：

Year:  2021        PMID： 33895328      PMCID： PMC8178458          DOI： 10.1016/j.ymthe.2021.04.020

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   12.910


  128 in total

Review 1.  Multiple sclerosis.

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Journal:  Ann Neurol       Date:  2012-10       Impact factor: 10.422

3.  Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes.

Authors:  Joaquin Jimenez; Wenche Jy; Lucia M Mauro; Lawrence L Horstman; Eugene R Ahn; Yeon S Ahn; Alireza Minagar
Journal:  Mult Scler       Date:  2005-06       Impact factor: 6.312

4.  Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury.

Authors:  Edward J Goetzl; Fanny M Elahi; Maja Mustapic; Dimitrios Kapogiannis; Moira Pryhoda; Anah Gilmore; Kimberly A Gorgens; Bradley Davidson; Anne-Charlotte Granholm; Aurélie Ledreux
Journal:  FASEB J       Date:  2019-01-03       Impact factor: 5.191

5.  Exosome secretion is a key pathway for clearance of pathological TDP-43.

Authors:  Yohei Iguchi; Lara Eid; Martin Parent; Geneviève Soucy; Christine Bareil; Yuichi Riku; Kaori Kawai; Shinnosuke Takagi; Mari Yoshida; Masahisa Katsuno; Gen Sobue; Jean-Pierre Julien
Journal:  Brain       Date:  2016-09-27       Impact factor: 13.501

6.  Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein.

Authors:  Kathrin Guitart; Gabriele Loers; Friedrich Buck; Ute Bork; Melitta Schachner; Ralf Kleene
Journal:  Glia       Date:  2016-03-16       Impact factor: 7.452

7.  Exosomes derived from human placenta-derived mesenchymal stem cells improve neurologic function by promoting angiogenesis after spinal cord injury.

Authors:  Ciliu Zhang; ChengLiang Zhang; Yan Xu; Chengjun Li; Yong Cao; Ping Li
Journal:  Neurosci Lett       Date:  2020-09-30       Impact factor: 3.046

8.  Analysis of extracellular RNA in cerebrospinal fluid.

Authors:  Julie A Saugstad; Theresa A Lusardi; Kendall R Van Keuren-Jensen; Jay I Phillips; Babett Lind; Christina A Harrington; Trevor J McFarland; Amanda L Courtright; Rebecca A Reiman; Ashish S Yeri; M Yashar S Kalani; P David Adelson; Jorge Arango; John P Nolan; Erika Duggan; Karen Messer; Johnny C Akers; Douglas R Galasko; Joseph F Quinn; Bob S Carter; Fred H Hochberg
Journal:  J Extracell Vesicles       Date:  2017-05-24

Review 9.  Neuroinflammation: friend and foe for ischemic stroke.

Authors:  Richard L Jayaraj; Sheikh Azimullah; Rami Beiram; Fakhreya Y Jalal; Gary A Rosenberg
Journal:  J Neuroinflammation       Date:  2019-07-10       Impact factor: 8.322

10.  Human extracellular vesicles and correlation with two clinical forms of toxoplasmosis.

Authors:  Allecineia Bispo da Cruz; Marta Marques Maia; Ingrid de Siqueira Pereira; Noemi Nosomi Taniwaki; Gislene Mitsue Namiyama; João Paulo Marochi Telles; Jose Ernesto Vidal; Lígia Cosentino Junqueira Franco Spegiorin; Cinara Cássia Brandão de Mattos; Luiz Carlos de Mattos; Cristina da Silva Meira-Strejevitch; Vera Lucia Pereira-Chioccola
Journal:  PLoS One       Date:  2020-03-03       Impact factor: 3.240
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  2 in total

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Review 2.  Role of extracellular vesicles in osteosarcoma.

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  2 in total

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