Vasiliki Katsi1, Georgios Georgiopoulos2,3,4, Panagiota Mitropoulou5, Konstantinos Kontoangelos6, Zoi Kollia7, Chara Tzavara7, Dimitrios Soulis7, Konstantinos Toutouzas1, Dimitrios Oikonomou1, Alberto Aimo8,9, Konstantinos Tsioufis1. 1. First Department of Cardiology, Hippocration Hospital, Athens, Greece. 2. First Department of Cardiology, Hippocration Hospital, Athens, Greece. georgiopoulosgeorgios@gmail.com. 3. Cardiovascular Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas Hospital, Westminster Bridge Road, London, SE1 7EH, UK. georgiopoulosgeorgios@gmail.com. 4. Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece. georgiopoulosgeorgios@gmail.com. 5. Department of Cardiology, University Hospital Southampton NHS Foundation Trust, Southampton, UK. 6. 1st Department of Psychiatry, Eginition Hospital, Medical School National and Kapodistrian University of Athens, Athens, Greece. 7. Emergency Department, Amalia Fleming' General Hospital, Athens, Greece. 8. Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. 9. Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Abstract
BACKGROUND: Coronary artery disease (CAD) is known to impact on patients' physical and mental health. The relationship between performance on treadmill exercise tolerance test (ETT) and health-related quality of life (HRQL)has never been specifically investigated in the setting of CAD. METHODS: Consecutive patients undergoing an ETT with the Bruce protocol during a diagnostic workup for CAD (n = 1,631, age 55 ± 12 years) were evaluated. Exercise-related indices were recorded. Detailed information on cardiovascular risk factors and past medical history were obtained. HRQLwas assessed with the use of the validated 36-Item Short Form Survey (SF-36) questionnaire. RESULTS: Increasing age and the presence of cardiovascular risk factors and comorbidities correlated with lower scores on the physical and mental health component of SF-36(all P < 0.05). Subjects with arrhythmias during exercise and slow recovery of systolic blood pressure had lower scores on the physical health indices or the Social Role Functioning component (P < 0.05). Achieved target heart rate and good exercise tolerance were independently associated with better scores of the physical and mental health domains of SF-36 and overall HRQLscores (β = 0.05 for target HR and PCS-36, β = 1.86 and β = 1.66 per increasing stage of exercise tolerance and PCS-36 and MCS-36, respectively, P < 0.001 for all associations). Ischemic ECG changes were associated with worse scores on Physical Functioning (β = - 3.2, P = 0.02) and Bodily Pain (β = - 4.55, P = 0.026). CONCLUSION: ETT parameters are associated with HRQL indices in patients evaluated for possible CAD. Physical conditioning may increase patient well-being and could serve as a complementary target in conjunction with cardiovascular drug therapy.
BACKGROUND:Coronary artery disease (CAD) is known to impact on patients' physical and mental health. The relationship between performance on treadmill exercise tolerance test (ETT) and health-related quality of life (HRQL)has never been specifically investigated in the setting of CAD. METHODS: Consecutive patients undergoing an ETT with the Bruce protocol during a diagnostic workup for CAD (n = 1,631, age 55 ± 12 years) were evaluated. Exercise-related indices were recorded. Detailed information on cardiovascular risk factors and past medical history were obtained. HRQLwas assessed with the use of the validated 36-Item Short Form Survey (SF-36) questionnaire. RESULTS: Increasing age and the presence of cardiovascular risk factors and comorbidities correlated with lower scores on the physical and mental health component of SF-36(all P < 0.05). Subjects with arrhythmias during exercise and slow recovery of systolic blood pressure had lower scores on the physical health indices or the Social Role Functioning component (P < 0.05). Achieved target heart rate and good exercise tolerance were independently associated with better scores of the physical and mental health domains of SF-36 and overall HRQLscores (β = 0.05 for target HR and PCS-36, β = 1.86 and β = 1.66 per increasing stage of exercise tolerance and PCS-36 and MCS-36, respectively, P < 0.001 for all associations). Ischemic ECG changes were associated with worse scores on Physical Functioning (β = - 3.2, P = 0.02) and Bodily Pain (β = - 4.55, P = 0.026). CONCLUSION: ETT parameters are associated with HRQL indices in patients evaluated for possible CAD. Physical conditioning may increase patient well-being and could serve as a complementary target in conjunction with cardiovascular drug therapy.
Entities:
Keywords:
Coronary heart disease; Mental health; Physical health; Quality of life; Treadmill exercise tolerance test
Authors: Alberico L Catapano; Ian Graham; Guy De Backer; Olov Wiklund; M John Chapman; Heinz Drexel; Arno W Hoes; Catriona S Jennings; Ulf Landmesser; Terje R Pedersen; Željko Reiner; Gabriele Riccardi; Marja-Riita Taskinen; Lale Tokgozoglu; W M Monique Verschuren; Charalambos Vlachopoulos; David A Wood; Jose Luis Zamorano; Marie-Therese Cooney Journal: Eur Heart J Date: 2016-08-27 Impact factor: 29.983
Authors: Tolulope T Sajobi; Meng Wang; Oluwagbohunmi Awosoga; Maria Santana; Danielle Southern; Zhiying Liang; Diane Galbraith; Stephen B Wilton; Hude Quan; Michelle M Graham; Matthew T James; William A Ghali; Merrill L Knudtson; Colleen Norris Journal: Circ Cardiovasc Qual Outcomes Date: 2018-03