Literature DB >> 33888571

Novel recessive locus for body mass index in childhood asthma.

Sanghun Lee1, Jessica Lasky-Su2, Sungho Won3, Cecelia Laurie4, Juan Carlos Celedón5, Christoph Lange6, Scott Weiss2, Julian Hecker2.   

Abstract

Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in FTO In two whole-genome sequencing (WGS) studies of children with asthma and their parents (892 Costa Rican trios and 286 North American trios), we discovered an association between a locus (rs9292139) in LOC102724122 and BMI that reaches genome-wide significance under a recessive model in the combined analysis. As the association does not achieve significance under an additive model, our finding illustrates the benefits of the recessive model in WGS analyses. © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  asthma genetics; paediatric asthma

Mesh：

Substances：

Year:  2021        PMID： 33888571      PMCID： PMC8531156          DOI： 10.1136/thoraxjnl-2020-215742

Source DB:  PubMed          Journal:  Thorax        ISSN： 0040-6376            Impact factor:   9.139


  10 in total

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3.  Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica.

Authors:  Gary M Hunninghake; Manuel E Soto-Quiros; Lydiana Avila; Ngoc P Ly; Catherine Liang; Jody S Sylvia; Barbara J Klanderman; Edwin K Silverman; Juan C Celedón
Journal:  J Allergy Clin Immunol       Date:  2007-03       Impact factor: 10.793

4.  A common genetic variant is associated with adult and childhood obesity.

Authors:  Alan Herbert; Norman P Gerry; Matthew B McQueen; Iris M Heid; Arne Pfeufer; Thomas Illig; H-Erich Wichmann; Thomas Meitinger; David Hunter; Frank B Hu; Graham Colditz; Anke Hinney; Johannes Hebebrand; Kerstin Koberwitz; Xiaofeng Zhu; Richard Cooper; Kristin Ardlie; Helen Lyon; Joel N Hirschhorn; Nan M Laird; Marc E Lenburg; Christoph Lange; Michael F Christman
Journal:  Science       Date:  2006-04-14       Impact factor: 47.728

5.  The Childhood Asthma Management Program (CAMP): Contributions to the Understanding of Therapy and the Natural History of Childhood Asthma.

Authors:  Ronina A Covar; Anne L Fuhlbrigge; Paul Williams; H William Kelly
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6.  Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

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Journal:  Mol Cell Proteomics       Date:  2013-12-05       Impact factor: 5.911

7.  A global reference for human genetic variation.

Authors:  Adam Auton; Lisa D Brooks; Richard M Durbin; Erik P Garrison; Hyun Min Kang; Jan O Korbel; Jonathan L Marchini; Shane McCarthy; Gil A McVean; Gonçalo R Abecasis
Journal:  Nature       Date:  2015-10-01       Impact factor: 49.962

8.  Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis.

Authors:  Fariba Ahmadizar; Susanne J H Vijverberg; Hubertus G M Arets; Anthonius de Boer; Jason E Lang; Meyer Kattan; Colin N A Palmer; Somnath Mukhopadhyay; Steve Turner; Anke H Maitland-van der Zee
Journal:  Eur Respir J       Date:  2016-09-01       Impact factor: 16.671

9.  EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.

Authors:  Bahram Namjou; Mehdi Keddache; Keith Marsolo; Michael Wagner; Todd Lingren; Beth Cobb; Cassandra Perry; Stephanie Kennebeck; Ingrid A Holm; Rongling Li; Nancy A Crimmins; Lisa Martin; Imre Solti; Isaac S Kohane; John B Harley
Journal:  Front Genet       Date:  2013-12-03       Impact factor: 4.599

10.  Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.

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Journal:  Nature       Date:  2021-02-10       Impact factor: 69.504
  10 in total
  1 in total

1.  Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma.

Authors:  Xikun Han; Zhaozhong Zhu; Qian Xiao; Jun Li; Xiumei Hong; Xiaobin Wang; Kohei Hasegawa; Carlos A Camargo; Liming Liang
Journal:  Commun Biol       Date:  2022-10-17
  1 in total

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