| Literature DB >> 16614226 |
Alan Herbert1, Norman P Gerry, Matthew B McQueen, Iris M Heid, Arne Pfeufer, Thomas Illig, H-Erich Wichmann, Thomas Meitinger, David Hunter, Frank B Hu, Graham Colditz, Anke Hinney, Johannes Hebebrand, Kerstin Koberwitz, Xiaofeng Zhu, Richard Cooper, Kristin Ardlie, Helen Lyon, Joel N Hirschhorn, Nan M Laird, Marc E Lenburg, Christoph Lange, Michael F Christman.
Abstract
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.Entities:
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Year: 2006 PMID： 16614226 DOI： 10.1126/science.1124779
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728