Sophie Deneuve1,2, Joanne Guerlain3, Agnès Dupret-Bories4, Claire Majoufre5, Pierre Philouze6, Philippe Ceruse6, Marion Perreard7, Nicolas Sigaud8, Béatrix Barry9, Pierre Ransy10, Philippe Schultz11, Olivier Malard12, Sylvain Morinière13, Anne Chatellier14, Erwan De Monès15, Mireille Folia16, François Virard17,18, Béatrice Fervers19,20. 1. Surgical Oncology Department, Léon Bérard Comprehensive Cancer Center, 28 rue Laennec, 69008, Lyon, France. fdeneuve@club.fr. 2. INSERM UA8, Radiation: Défense, Santé , Environnement, Lyon, France. fdeneuve@club.fr. 3. Head and Neck Department, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. 4. Head and Neck Department, Toulouse University Cancer Institute, Toulouse, France. 5. Maxillofacial Surgery, CHU Bordeaux Pellegrin, Bordeaux, France. 6. ENT Department, CHU Croix Rousse, Lyon, France. 7. ENT Department, CHU Caen, Caen, France. 8. Maxillofacial Surgery, CHU Lyon Sud, Pierre-Bénite, France. 9. ENT Department, CHU Bichat, Paris, France. 10. ENT Department, CHU Lieges, Liège, Belgium. 11. ENT Department, CHU Strasbourg, Strasbourg, France. 12. ENT Department, CHU Nantes, Nantes, France. 13. ENT Department, CHU Tours, Tours, France. 14. Maxillofacial Surgery, CHU Caen, Caen, France. 15. ENT Department, CHU Bordeaux, Bordeaux, France. 16. ENT Department, CHU Dijon, Dijon, France. 17. INSERM U1052-CNRS UMR5286, Cancer Research Center, centre Léon Berard, Lyon 1 University, Lyon, France. 18. Université de Lyon, Faculté d'Odontologie, Hospices Civils de Lyon, Lyon, France. 19. INSERM UA8, Radiation: Défense, Santé , Environnement, Lyon, France. 20. Cancer and Environnement Department, Léon Bérard Comprehensive Cancer Center, Lyon, France.
Abstract
BACKGROUND: Incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing, especially in young adults, despite decreasing tobacco and alcohol consumption. METHODS: This multicentric retrospective study of 185 young adults with OTSCC (median follow-up 43 months), investigated risk factors, tumour characteristics and oncological outcomes according to the smoking status. RESULTS: Overall, 38% of patients were smokers (S). Non-smokers (NS) were significantly younger than S. Sex ratios were 1.1 for N and 1.8 for S. NS patients were less frequently cannabis or alcohol users than S, but were more likely to have a history of leukoplakia. Second primaries were observed in NS (4.4%) and in S (12.7%). Despite more frequent local relapse in NS (p = 0.018), there was no difference in diagnostic stage and overall survival between groups. CONCLUSION: OTSCC affects differently young S and NS patients suggesting the existence of a specific clinical entity of OTSCC in non-smoking young adults.
BACKGROUND: Incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing, especially in young adults, despite decreasing tobacco and alcohol consumption. METHODS: This multicentric retrospective study of 185 young adults with OTSCC (median follow-up 43 months), investigated risk factors, tumour characteristics and oncological outcomes according to the smoking status. RESULTS: Overall, 38% of patients were smokers (S). Non-smokers (NS) were significantly younger than S. Sex ratios were 1.1 for N and 1.8 for S. NS patients were less frequently cannabis or alcohol users than S, but were more likely to have a history of leukoplakia. Second primaries were observed in NS (4.4%) and in S (12.7%). Despite more frequent local relapse in NS (p = 0.018), there was no difference in diagnostic stage and overall survival between groups. CONCLUSION: OTSCC affects differently young S and NS patients suggesting the existence of a specific clinical entity of OTSCC in non-smoking young adults.
Authors: Ryan Li; Daniel L Faden; Carole Fakhry; Chaz Langelier; Yuchen Jiao; Yuxuan Wang; Matthew D Wilkerson; Chandra Sekhar Pedamallu; Matthew Old; James Lang; Myriam Loyo; Sun Mi Ahn; Marietta Tan; Zhen Gooi; Jason Chan; Jeremy Richmon; Laura D Wood; Ralph H Hruban; Justin Bishop; William H Westra; Christine H Chung; Joseph Califano; Christine G Gourin; Chetan Bettegowda; Matthew Meyerson; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Joseph L DeRisi; Wayne M Koch; Nishant Agrawal Journal: Head Neck Date: 2014-08-23 Impact factor: 3.147
Authors: Mark E Zafereo; Li Xu; Kristina R Dahlstrom; Carlo A Viamonte; Adel K El-Naggar; Qingyi Wei; Guojun Li; Erich M Sturgis Journal: Oral Oncol Date: 2016-03-21 Impact factor: 5.337
Authors: Sagar C Patel; William R Carpenter; Seth Tyree; Marion Everett Couch; Mark Weissler; Trevor Hackman; D Neil Hayes; Carol Shores; Bhishamjit S Chera Journal: J Clin Oncol Date: 2011-03-07 Impact factor: 44.544
Authors: J Brägelmann; I Dagogo-Jack; M El Dinali; T Stricker; C D Brown; Z Zuo; A Khattri; M Keck; M E McNerney; R Longnecker; K Bieging; M Kocherginsky; K Alexander; R Salgia; M W Lingen; E E Vokes; K P White; E E W Cohen; T Y Seiwert Journal: Oral Oncol Date: 2013-03-13 Impact factor: 5.337
Authors: Mark W Lingen; Weihong Xiao; Alessandra Schmitt; Bo Jiang; Robert Pickard; Paul Kreinbrink; Bayardo Perez-Ordonez; Richard C Jordan; Maura L Gillison Journal: Oral Oncol Date: 2012-07-28 Impact factor: 5.337
Authors: Joseph E Tota; William F Anderson; Charles Coffey; Joseph Califano; Wendy Cozen; Robert L Ferris; Maie St John; Ezra E W Cohen; Anil K Chaturvedi Journal: Oral Oncol Date: 2017-02-28 Impact factor: 5.972
Authors: Theodore R Holford; Rafael Meza; Kenneth E Warner; Clare Meernik; Jihyoun Jeon; Suresh H Moolgavkar; David T Levy Journal: JAMA Date: 2014-01-08 Impact factor: 157.335