| Literature DB >> 3386835 |
T R Browne1, G K Szabo, J E Evans, B A Evans, D J Greenblatt, M A Mikati.
Abstract
Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.Entities:
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Year: 1988 PMID： 3386835 DOI： 10.1212/wnl.38.7.1146
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910