Sandra Zebaze Ndendjio1, Wenjin Liu1,2, Nicolas Yvanez1,3, Zihui Meng2, Peter Y Zavalij1, Lyle Isaacs1. 1. Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA. 2. School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, P. R. China. 3. École Nationale Supérieure de Chimie de Paris, 11 rue Pierre et Marie Curie, F75231 Paris cedex 05, France.
Abstract
We report the synthesis of a new acyclic CB[n]-type host (1) that features a central glycoluril trimer capped by triptycene sidewalls. Host 1 has good solubility in water (≈ 3 mM) and does not undergo strong self-association (Ks = 480 M-1). We probed the geometry of the complexes by analyzing the complexation induced changes in the 1H NMR spectra and measured the complexation thermodynamics by isothermal titration calorimetry. The conformation of 1 and its packing in the solid state was revealed by single crystal x-ray diffraction measurements.
We report the synthesis of a new acyclic CB[n]-type host (1) that features a central n class="Chemical">glycoluril trimer capped by triptycene sidewalls. Host 1 has good solubility in water (≈ 3 mM) and does not undergo strong self-association (Ks = 480 M-1). We probed the geometry of the complexes by analyzing the complexation induced changes in the 1H NMR spectra and measured the complexation thermodynamics by isothermal titration calorimetry. The conformation of 1 and its packing in the solid state was revealed by single crystal x-ray diffraction measurements.
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