Literature DB >> 33860081

Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage.

Diletta Fontana1, Carlo Gambacorti-Passerini1,2, Rocco Piazza1,2,3.   

Abstract

Recently we showed that Ethanolamine Kinase 1 (ETNK1) mutations cause a decreased synthesis of phosphoethanolamine, and that phosphoethanolamine is able to modulate mitochondrial activity through competition with succinate for complex II. The decreased phosphoethanolamine concentration leads to increased mitochondria activity and reactive oxygen species production, which causes the accumulation of new mutations.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  DNA damage; ETNK1; mitochondria; phosphoethanolamine; reactive oxigen species

Year:  2021        PMID： 33860081      PMCID： PMC8018496          DOI： 10.1080/23723556.2021.1877598

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The function of cytidine coenzymes in the biosynthesis of phospholipides.

Authors:  E P KENNEDY; S B WEISS
Journal:  J Biol Chem       Date:  1956-09       Impact factor: 5.157

2.  Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type.

Authors:  Xiaolong Alan Zhou; Abner Louissaint; Alexander Wenzel; Jingyi Yang; Maria Estela Martinez-Escala; Andrea P Moy; Elizabeth A Morgan; Christian N Paxton; Bo Hong; Erica F Andersen; Joan Guitart; Amir Behdad; Lorenzo Cerroni; David M Weinstock; Jaehyuk Choi
Journal:  J Invest Dermatol       Date:  2018-05-30       Impact factor: 8.551

3.  Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.

Authors:  Carlo B Gambacorti-Passerini; Carla Donadoni; Andrea Parmiani; Alessandra Pirola; Sara Redaelli; Giovanni Signore; Vincenzo Piazza; Luca Malcovati; Diletta Fontana; Roberta Spinelli; Vera Magistroni; Giuseppe Gaipa; Marco Peronaci; Alessandro Morotti; Cristina Panuzzo; Giuseppe Saglio; Emilio Usala; Dong-Wook Kim; Delphine Rea; Konstantinos Zervakis; Nora Viniou; Argiris Symeonidis; Heiko Becker; Jacqueline Boultwood; Leonardo Campiotti; Matteo Carrabba; Elena Elli; Graham R Bignell; Elli Papaemmanuil; Peter J Campbell; Mario Cazzola; Rocco Piazza
Journal:  Blood       Date:  2014-10-24       Impact factor: 22.113

Review 4.  Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Authors:  Simran S Sabharwal; Paul T Schumacker
Journal:  Nat Rev Cancer       Date:  2014-11       Impact factor: 60.716

5.  Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology.

Authors:  Guergana Tasseva; Helin Daniel Bai; Magdalena Davidescu; Alois Haromy; Evangelos Michelakis; Jean E Vance
Journal:  J Biol Chem       Date:  2012-12-18       Impact factor: 5.157

6.  Recurrent SETBP1 mutations in atypical chronic myeloid leukemia.

Authors:  Rocco Piazza; Simona Valletta; Nils Winkelmann; Sara Redaelli; Roberta Spinelli; Alessandra Pirola; Laura Antolini; Luca Mologni; Carla Donadoni; Elli Papaemmanuil; Susanne Schnittger; Dong-Wook Kim; Jacqueline Boultwood; Fabio Rossi; Giuseppe Gaipa; Greta P De Martini; Paola Francia di Celle; Hyun Gyung Jang; Valeria Fantin; Graham R Bignell; Vera Magistroni; Torsten Haferlach; Enrico Maria Pogliani; Peter J Campbell; Andrew J Chase; William J Tapper; Nicholas C P Cross; Carlo Gambacorti-Passerini
Journal:  Nat Genet       Date:  2012-12-09       Impact factor: 38.330

7.  Novel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia.

Authors:  T L Lasho; C M Finke; D Zblewski; M Patnaik; R P Ketterling; D Chen; C A Hanson; A Tefferi; A Pardanani
Journal:  Blood Cancer J       Date:  2015-01-23       Impact factor: 11.037

8.  SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.

Authors:  Rocco Piazza; Vera Magistroni; Sara Redaelli; Mario Mauri; Luca Massimino; Alessandro Sessa; Marco Peronaci; Maciej Lalowski; Rabah Soliymani; Caterina Mezzatesta; Alessandra Pirola; Federica Banfi; Alicia Rubio; Delphine Rea; Fabio Stagno; Emilio Usala; Bruno Martino; Leonardo Campiotti; Michele Merli; Francesco Passamonti; Francesco Onida; Alessandro Morotti; Francesca Pavesi; Marco Bregni; Vania Broccoli; Marc Baumann; Carlo Gambacorti-Passerini
Journal:  Nat Commun       Date:  2018-06-06       Impact factor: 14.919

9.  ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine.

Authors:  Diletta Fontana; Mario Mauri; Rossella Renso; Mattia Docci; Ilaria Crespiatico; Lisa M Røst; Mi Jang; Antonio Niro; Deborah D'Aliberti; Luca Massimino; Mayla Bertagna; Giovanni Zambrotta; Mario Bossi; Stefania Citterio; Barbara Crescenzi; Francesca Fanelli; Valeria Cassina; Roberta Corti; Domenico Salerno; Luca Nardo; Clizia Chinello; Francesco Mantegazza; Cristina Mecucci; Fulvio Magni; Guido Cavaletti; Per Bruheim; Delphine Rea; Steen Larsen; Carlo Gambacorti-Passerini; Rocco Piazza
Journal:  Nat Commun       Date:  2020-11-23       Impact factor: 14.919

10.  Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia.

Authors:  Diletta Fontana; Daniele Ramazzotti; Andrea Aroldi; Sara Redaelli; Vera Magistroni; Alessandra Pirola; Antonio Niro; Luca Massimino; Cristina Mastini; Virginia Brambilla; Silvia Bombelli; Silvia Bungaro; Alessandro Morotti; Delphine Rea; Fabio Stagno; Bruno Martino; Leonardo Campiotti; Giovanni Caocci; Emilio Usala; Michele Merli; Francesco Onida; Marco Bregni; Elena Maria Elli; Monica Fumagalli; Fabio Ciceri; Roberto A Perego; Fabio Pagni; Luca Mologni; Rocco Piazza; Carlo Gambacorti-Passerini
Journal:  Hemasphere       Date:  2020-11-06
  10 in total

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