Literature DB >> 33854246

The race for antiviral drugs to beat COVID - and the next pandemic.

Elie Dolgin.   

Abstract

Entities:  

Keywords:  Drug discovery; SARS-CoV-2; Virology

Mesh:

Substances:

Year:  2021        PMID: 33854246     DOI: 10.1038/d41586-021-00958-4

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


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  6 in total

1.  Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Authors:  Timothy P Sheahan; Amy C Sims; Rachel L Graham; Vineet D Menachery; Lisa E Gralinski; James B Case; Sarah R Leist; Krzysztof Pyrc; Joy Y Feng; Iva Trantcheva; Roy Bannister; Yeojin Park; Darius Babusis; Michael O Clarke; Richard L Mackman; Jamie E Spahn; Christopher A Palmiotti; Dustin Siegel; Adrian S Ray; Tomas Cihlar; Robert Jordan; Mark R Denison; Ralph S Baric
Journal:  Sci Transl Med       Date:  2017-06-28       Impact factor: 17.956

2.  Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.

Authors:  Robert L Hoffman; Robert S Kania; Mary A Brothers; Jay F Davies; Rose A Ferre; Ketan S Gajiwala; Mingying He; Robert J Hogan; Kirk Kozminski; Lilian Y Li; Jonathan W Lockner; Jihong Lou; Michelle T Marra; Lennert J Mitchell; Brion W Murray; James A Nieman; Stephen Noell; Simon P Planken; Thomas Rowe; Kevin Ryan; George J Smith; James E Solowiej; Claire M Steppan; Barbara Taggart
Journal:  J Med Chem       Date:  2020-10-15       Impact factor: 7.446

3.  Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide.

Authors:  Joshua A Jackman; Vivian V Costa; Soohyun Park; Ana Luiza C V Real; Jae Hyeon Park; Pablo L Cardozo; Abdul Rahim Ferhan; Isabella G Olmo; Thaiane P Moreira; Jordana L Bambirra; Victoria F Queiroz; Celso M Queiroz-Junior; Giselle Foureaux; Danielle G Souza; Fabiola M Ribeiro; Bo Kyeong Yoon; Evelien Wynendaele; Bart De Spiegeleer; Mauro M Teixeira; Nam-Joon Cho
Journal:  Nat Mater       Date:  2018-10-22       Impact factor: 43.841

4.  Remdesivir for the Treatment of Covid-19 - Final Report.

Authors:  John H Beigel; Kay M Tomashek; Lori E Dodd; Aneesh K Mehta; Barry S Zingman; Andre C Kalil; Elizabeth Hohmann; Helen Y Chu; Annie Luetkemeyer; Susan Kline; Diego Lopez de Castilla; Robert W Finberg; Kerry Dierberg; Victor Tapson; Lanny Hsieh; Thomas F Patterson; Roger Paredes; Daniel A Sweeney; William R Short; Giota Touloumi; David Chien Lye; Norio Ohmagari; Myoung-Don Oh; Guillermo M Ruiz-Palacios; Thomas Benfield; Gerd Fätkenheuer; Mark G Kortepeter; Robert L Atmar; C Buddy Creech; Jens Lundgren; Abdel G Babiker; Sarah Pett; James D Neaton; Timothy H Burgess; Tyler Bonnett; Michelle Green; Mat Makowski; Anu Osinusi; Seema Nayak; H Clifford Lane
Journal:  N Engl J Med       Date:  2020-10-08       Impact factor: 91.245

5.  An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.

Authors:  Timothy P Sheahan; Amy C Sims; Shuntai Zhou; Rachel L Graham; Andrea J Pruijssers; Maria L Agostini; Sarah R Leist; Alexandra Schäfer; Kenneth H Dinnon; Laura J Stevens; James D Chappell; Xiaotao Lu; Tia M Hughes; Amelia S George; Collin S Hill; Stephanie A Montgomery; Ariane J Brown; Gregory R Bluemling; Michael G Natchus; Manohar Saindane; Alexander A Kolykhalov; George Painter; Jennifer Harcourt; Azaibi Tamin; Natalie J Thornburg; Ronald Swanstrom; Mark R Denison; Ralph S Baric
Journal:  Sci Transl Med       Date:  2020-04-06       Impact factor: 17.956

6.  Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.

Authors:  Hongchao Pan; Richard Peto; Ana-Maria Henao-Restrepo; Marie-Pierre Preziosi; Vasee Sathiyamoorthy; Quarraisha Abdool Karim; Marissa M Alejandria; César Hernández García; Marie-Paule Kieny; Reza Malekzadeh; Srinivas Murthy; K Srinath Reddy; Mirta Roses Periago; Pierre Abi Hanna; Florence Ader; Abdullah M Al-Bader; Almonther Alhasawi; Emma Allum; Athari Alotaibi; Carlos A Alvarez-Moreno; Sheila Appadoo; Abdullah Asiri; Pål Aukrust; Andreas Barratt-Due; Samir Bellani; Mattia Branca; Heike B C Cappel-Porter; Nery Cerrato; Ting S Chow; Najada Como; Joe Eustace; Patricia J García; Sheela Godbole; Eduardo Gotuzzo; Laimonas Griskevicius; Rasha Hamra; Mariam Hassan; Mohamed Hassany; David Hutton; Irmansyah Irmansyah; Ligita Jancoriene; Jana Kirwan; Suresh Kumar; Peter Lennon; Gustavo Lopardo; Patrick Lydon; Nicola Magrini; Teresa Maguire; Suzana Manevska; Oriol Manuel; Sibylle McGinty; Marco T Medina; María L Mesa Rubio; Maria C Miranda-Montoya; Jeremy Nel; Estevao P Nunes; Markus Perola; Antonio Portolés; Menaldi R Rasmin; Aun Raza; Helen Rees; Paula P S Reges; Chris A Rogers; Kolawole Salami; Marina I Salvadori; Narvina Sinani; Jonathan A C Sterne; Milena Stevanovikj; Evelina Tacconelli; Kari A O Tikkinen; Sven Trelle; Hala Zaid; John-Arne Røttingen; Soumya Swaminathan
Journal:  N Engl J Med       Date:  2020-12-02       Impact factor: 91.245

  6 in total
  17 in total

1.  Enabling evidence to tackle everyday diseases to mitigate another pandemic.

Authors:  Trudie Lang
Journal:  Gates Open Res       Date:  2022-04-07

2.  Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

Authors:  Bing Bai; Elena Arutyunova; Muhammad Bashir Khan; Jimmy Lu; Michael A Joyce; Holly A Saffran; Justin A Shields; Appan Srinivas Kandadai; Alexandr Belovodskiy; Mostofa Hena; Wayne Vuong; Tess Lamer; Howard S Young; John C Vederas; D Lorne Tyrrell; M Joanne Lemieux; James A Nieman
Journal:  RSC Med Chem       Date:  2021-08-20

Review 3.  Nanoagent-based theranostic strategies against human coronaviruses.

Authors:  Tao Feng; Chaofan Nie; Pandi Peng; Hui Lu; Tengjiao Wang; Peng Li; Wei Huang
Journal:  Nano Res       Date:  2022-01-05       Impact factor: 10.269

Review 4.  An update of anti-viral treatment of COVID-19

Authors:  Serap Şimşek-Yavuz; Feride Ipek Komsuoğlu Çelikyurt
Journal:  Turk J Med Sci       Date:  2021-12-17       Impact factor: 0.973

Review 5.  Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses.

Authors:  Judith M White; Joshua T Schiffer; Rachel A Bender Ignacio; Shuang Xu; Denis Kainov; Aleksandr Ianevski; Tero Aittokallio; Matthew Frieman; Gene G Olinger; Stephen J Polyak
Journal:  mBio       Date:  2021-12-21       Impact factor: 7.867

Review 6.  Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2.

Authors:  Brian F Niemeyer; Kambez H Benam
Journal:  Pharmacol Ther       Date:  2021-10-28       Impact factor: 13.400

7.  Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro.

Authors:  Yabin Song; Yongqiang Deng; Huiqiang Wang; Zhuchun Bei; Hongjing Gu; Hui Zhao; Hong Wang; Dongna Zhang; Likun Xu; Baogang Wang; Yuhuan Li; Hongquan Wang
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411

8.  Insights into the binding and covalent inhibition mechanism of PF-07321332 to SARS-CoV-2 Mpro.

Authors:  Son Tung Ngo; Trung Hai Nguyen; Nguyen Thanh Tung; Binh Khanh Mai
Journal:  RSC Adv       Date:  2022-01-28       Impact factor: 3.361

Review 9.  Leishmaniac Quest for Developing a Novel Vaccine Platform. Is a Roadmap for Its Advances Provided by the Mad Dash to Produce Vaccines for COVID-19?

Authors:  Kwang Poo Chang; Joseph M Reynolds; Ying Liu; Johnny J He
Journal:  Vaccines (Basel)       Date:  2022-02-07

10.  Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Authors:  Martin A Redhead; C David Owen; Lennart Brewitz; Amelia H Collette; Petra Lukacik; Claire Strain-Damerell; Sean W Robinson; Patrick M Collins; Philipp Schäfer; Mark Swindells; Chris J Radoux; Iva Navratilova Hopkins; Daren Fearon; Alice Douangamath; Frank von Delft; Tika R Malla; Laura Vangeel; Thomas Vercruysse; Jan Thibaut; Pieter Leyssen; Tu-Trinh Nguyen; Mitchell Hull; Anthony Tumber; David J Hallett; Christopher J Schofield; David I Stuart; Andrew L Hopkins; Martin A Walsh
Journal:  Sci Rep       Date:  2021-06-24       Impact factor: 4.379

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