Literature DB >> 3384983

Degree of differentiation in colorectal adenocarcinomas: a multivariate analysis of the influence on survival.

T B Halvorsen1, E Seim.   

Abstract

Three hundred and sixty eight resected colorectal adenocarcinomas were graded (WHO) retrospectively and the results correlated with estimated length of patient survival. In 30 (82%) of the tumours more than one degree of differentiation was found. Histological grade significantly influenced survival time when other explanatory variables such as tumour site and stage, age, and sex were adjusted for. The results suggested that three degrees of differentiation (well, moderate, and poor) are sufficient for the grading of colorectal carcinomas, and that grading should be based on the predominating degree of differentiation represented in the primary tumour.

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Year:  1988        PMID： 3384983      PMCID： PMC1141506          DOI： 10.1136/jcp.41.5.532

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  13 in total

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Authors:  J D Godwin; C C Brown
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Authors:  W K Blenkinsopp; S Stewart-Brown; L Blesovsky; G Kearney; L P Fielding
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5.  The role of surgical local excision in the treatment of rectal cancer.

Authors:  J Whiteway; R J Nicholls; B C Morson
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Review 6.  The pathogenesis of cancer metastasis.

Authors:  G Poste; I J Fidler
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7.  Rectal biopsies: inaccuracy of histological grading in carcinoma of the rectum.

Authors:  F H Smedley; R W Hoile; D A Macfarlane
Journal:  J R Soc Med       Date:  1984-07       Impact factor: 5.344

8.  Site distribution of colorectal adenocarcinomas. A retrospective study of 853 tumours.

Authors:  T B Halvorsen
Journal:  Scand J Gastroenterol       Date:  1986-10       Impact factor: 2.423

9.  Observer variation in the histological grading of rectal carcinoma.

Authors:  G D Thomas; M F Dixon; N C Smeeton; N S Williams
Journal:  J Clin Pathol       Date:  1983-04       Impact factor: 3.411

10.  The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases.

Authors:  J R Jass; W S Atkin; J Cuzick; H J Bussey; B C Morson; J M Northover; I P Todd
Journal:  Histopathology       Date:  1986-05       Impact factor: 5.087
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  18 in total

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Authors:  S H Burroughs; G T Williams
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Authors:  T B Halvorsen; E Seim
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5.  Do aggressive subclones within primary colorectal cancer give rise to liver metastases?

Authors:  J R Jass; K Mukawa; P I Richman; P A Hall
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Review 6.  [Clinical, pathological and molecular prognostic factors in colorectal carcinomas].

Authors:  S E Baldus
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7.  Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer.

Authors:  T B Halvorsen; E Seim
Journal:  J Clin Pathol       Date:  1989-02       Impact factor: 3.411

8.  Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil.

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