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Literature DB >> 33846949

Gastric Bypass Compared with Sleeve Gastrectomy for Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis.

Miller Barreto de Brito E Silva¹, Francisco Tustumi², Antonio Afonso de Miranda Neto¹, Anna Carolina Batista Dantas¹, Marco Aurélio Santo¹, Ivan Cecconello¹.

Abstract

The effects of bariatric procedures on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain unclear. A systematic review and meta-analysis was performed to compare the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on NAFLD/NASH. Patients submitted to RYGB presented significant reduction of steatohepatitis (RD: 0.53; 95% CI 0.33 to 0.74) and fibrosis (RD: 0.26; 95% CI 0.14 to 0.37). SG caused a significant reduction of steatohepatitis (RD: 0.42; 95% CI 0.27 to 0.57), but not of fibrosis (RD: 0.20; 95% CI -0.00 to 0.39). The NAFLD Activity Score was significantly improved after both procedures, as well as biochemical tests. No difference was found between RYGB and SG regarding the histopathological outcomes. SG and RYGB are equivalently effective for treating NAFLD/NASH.

Entities: Disease Species

Keywords: Bariatric surgery; Metabolic syndrome; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Obesity

Mesh：

Year: 2021 PMID： 33846949 DOI： 10.1007/s11695-021-05412-y

Source DB: PubMed Journal: Obes Surg ISSN： 0960-8923 Impact factor: 4.129

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