| Literature DB >> 33835227 |
Muhammad Afzal1, Khalid Saad Alharbi2, Sami I Alzarea2, Anwarulabedin Mohsin Quazi2, Dhaval M Patel3, Advaita B Patel3, Riddhi Trivedi3, Imran Kazmi4, Fahad A Al-Abaasi4.
Abstract
Evaluation of the effects of methanolic extract of Cucumis melo in ethylene glycol-induced nephrolithiasis on Wistar rats. 0.75% solution of ethylene glycol (EG) in payable water was given to produce nephrolithiasis on Wistar rats. The action of oral intake of methanolic extract of Cucumis melo seed in nephrolithiasis is studied and is matched with the action of oral intake of Cystone (standard) on Wistar rats. EG resulted in hyperoxaluria and deposition of calcium oxalate as well as raised urinary excretion of oxalate and calcium. Supplementation with methanolic extract of Cucumis melo seed decreased the increased renal oxalate, indicating a regulatory effect on oxalate formation endogenously. The outcomes stipulate that the seed of Cucumis melo is endowed with antinephrolithiatic action.Entities:
Keywords: Analysis of variance; Cucumis melo; Cystone; Hyperoxaluria
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Year: 2021 PMID： 33835227 DOI： 10.1007/s00240-021-01263-5
Source DB: PubMed Journal: Urolithiasis ISSN： 2194-7228 Impact factor: 3.436