| Literature DB >> 33834439 |
Doyeon Kim1, Sangyun Lee2, Moosung Lee2, Juntaek Oh2, Su-A Yang3, YongKeun Park4,5,6.
Abstract
Live cell imaging provides essential information in the investigation of cell biology and related pathophysiology. Refractive index (RI) can serve as intrinsic optical imaging contrast for 3-D label-free and quantitative live cell imaging, and provide invaluable information to understand various dynamics of cells and tissues for the study of numerous fields. Recently significant advances have been made in imaging methods and analysis approaches utilizing RI, which are now being transferred to biological and medical research fields, providing novel approaches to investigate the pathophysiology of cells. To provide insight into how RI can be used as an imaging contrast for imaging of biological specimens, here we provide the basic principle of RI-based imaging techniques and summarize recent progress on applications, ranging from microbiology, hematology, infectious diseases, hematology, and histopathology.Entities:
Keywords: Biological imaging; Holotomography; Live cell imaging; Microscopy; Quantitative phase imaging; Refractive index
Mesh：
Year: 2021 PMID： 33834439 DOI： 10.1007/978-981-33-6064-8_10
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622