| Literature DB >> 33834412 |
Michele Fornaro1,2, Domenico De Berardis3,4, Annalisa Anastasia3, Andrea Fusco5.
Abstract
Major depressive disorder carries a significant burden and a high risk for suicide. The need for more effective, safer, and faster-acting drugs is, therefore, compelling. The present chapter briefly assesses the most promising agents, focusing on non-monoamine-targeting compounds, namely, the glutamate antagonist ketamine and its enantiomer esketamine. A critical overview of the evidence and the pitfalls associated with current antidepressant drug development is likewise provided in the following text.Entities:
Keywords: Esketamine; Ketamine; Major depressive disorder; Novel antidepressant; Treatment resistance
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Year: 2021 PMID: 33834412 DOI: 10.1007/978-981-33-6044-0_22
Source DB: PubMed Journal: Adv Exp Med Biol ISSN: 0065-2598 Impact factor: 2.622