Literature DB >> 33831364

Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH.

Daniel M Ramos1, William C Skarnes2, Andrew B Singleton3, Mark R Cookson4, Michael E Ward5.   

Abstract

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared. Published by Elsevier Inc.

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Year:  2021        PMID： 33831364      PMCID： PMC8985232          DOI： 10.1016/j.neuron.2021.03.022

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  9 in total

1.  iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

Authors:  Edsel M Abud; Ricardo N Ramirez; Eric S Martinez; Luke M Healy; Cecilia H H Nguyen; Sean A Newman; Andriy V Yeromin; Vanessa M Scarfone; Samuel E Marsh; Cristhian Fimbres; Chad A Caraway; Gianna M Fote; Abdullah M Madany; Anshu Agrawal; Rakez Kayed; Karen H Gylys; Michael D Cahalan; Brian J Cummings; Jack P Antel; Ali Mortazavi; Monica J Carson; Wayne W Poon; Mathew Blurton-Jones
Journal:  Neuron       Date:  2017-04-19       Impact factor: 17.173

2.  A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.

Authors:  Dylan Kwart; Andrew Gregg; Claudia Scheckel; Elisabeth A Murphy; Dominik Paquet; Michael Duffield; John Fak; Olav Olsen; Robert B Darnell; Marc Tessier-Lavigne
Journal:  Neuron       Date:  2019-08-12       Impact factor: 17.173

Review 3.  The Parkinson Progression Marker Initiative (PPMI).

Authors: 
Journal:  Prog Neurobiol       Date:  2011-09-14       Impact factor: 10.885

Review 4.  CRISPR/Cas9 for Human Genome Engineering and Disease Research.

Authors:  Xin Xiong; Meng Chen; Wendell A Lim; Dehua Zhao; Lei S Qi
Journal:  Annu Rev Genomics Hum Genet       Date:  2016-05-23       Impact factor: 8.929

5.  The human-induced pluripotent stem cell initiative-data resources for cellular genetics.

Authors:  Ian Streeter; Peter W Harrison; Adam Faulconbridge; Paul Flicek; Helen Parkinson; Laura Clarke
Journal:  Nucleic Acids Res       Date:  2016-10-12       Impact factor: 16.971

6.  A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.

Authors:  Celeste M Karch; Aimee W Kao; Anna Karydas; Khadijah Onanuga; Rita Martinez; Andrea Argouarch; Chao Wang; Cindy Huang; Peter Dongmin Sohn; Kathryn R Bowles; Salvatore Spina; M Catarina Silva; Jacob A Marsh; Simon Hsu; Derian A Pugh; Nupur Ghoshal; Joanne Norton; Yadong Huang; Suzee E Lee; William W Seeley; Panagiotis Theofilas; Lea T Grinberg; Fermin Moreno; Kathryn McIlroy; Bradley F Boeve; Nigel J Cairns; John F Crary; Stephen J Haggarty; Justin K Ichida; Kenneth S Kosik; Bruce L Miller; Li Gan; Alison M Goate; Sally Temple
Journal:  Stem Cell Reports       Date:  2019-10-17       Impact factor: 7.294

Review 7.  In vitro Models of Neurodegenerative Diseases.

Authors:  Anna Slanzi; Giulia Iannoto; Barbara Rossi; Elena Zenaro; Gabriela Constantin
Journal:  Front Cell Dev Biol       Date:  2020-05-13

8.  Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.

Authors:  Chao Wang; Michael E Ward; Robert Chen; Kai Liu; Tara E Tracy; Xu Chen; Min Xie; Peter Dongmin Sohn; Connor Ludwig; Anke Meyer-Franke; Celeste M Karch; Sheng Ding; Li Gan
Journal:  Stem Cell Reports       Date:  2017-09-28       Impact factor: 7.765

9.  PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.

Authors:  Henna Konttinen; Mauricio E Castro Cabral-da-Silva; Sohvi Ohtonen; Sara Wojciechowski; Anastasia Shakirzyanova; Simone Caligola; Rosalba Giugno; Yevheniia Ishchenko; Damián Hernández; Mohammad Feroze Fazaludeen; Shaila Eamen; Mireia Gómez Budia; Ilkka Fagerlund; Flavia Scoyni; Paula Korhonen; Nadine Huber; Annakaisa Haapasalo; Alex W Hewitt; James Vickers; Grady C Smith; Minna Oksanen; Caroline Graff; Katja M Kanninen; Sarka Lehtonen; Nicholas Propson; Michael P Schwartz; Alice Pébay; Jari Koistinaho; Lezanne Ooi; Tarja Malm
Journal:  Stem Cell Reports       Date:  2019-09-12       Impact factor: 7.765
  9 in total
  6 in total

Review 1.  Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation.

Authors:  Elisa Giacomelli; Björn F Vahsen; Elizabeth L Calder; Yinyan Xu; Jakub Scaber; Elizabeth Gray; Ruxandra Dafinca; Kevin Talbot; Lorenz Studer
Journal:  Cell Stem Cell       Date:  2022-01-06       Impact factor: 24.633

2.  Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.

Authors:  Julia Tcw; Lu Qian; Nina H Pipalia; Michael J Chao; Shuang A Liang; Yang Shi; Bharat R Jain; Sarah E Bertelsen; Manav Kapoor; Edoardo Marcora; Elizabeth Sikora; Elizabeth J Andrews; Alessandra C Martini; Celeste M Karch; Elizabeth Head; David M Holtzman; Bin Zhang; Minghui Wang; Frederick R Maxfield; Wayne W Poon; Alison M Goate
Journal:  Cell       Date:  2022-06-23       Impact factor: 66.850

3.  Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant.

Authors:  Zhefu Que; Maria I Olivero-Acosta; Jingliang Zhang; Muriel Eaton; Anke M Tukker; Xiaoling Chen; Jiaxiang Wu; Junkai Xie; Tiange Xiao; Kyle Wettschurack; Layan Yunis; J Marshall Shafer; James A Schaber; Jean-Christophe Rochet; Aaron B Bowman; Chongli Yuan; Zhuo Huang; Chang-Deng Hu; Darci J Trader; William C Skarnes; Yang Yang
Journal:  J Neurosci       Date:  2021-10-29       Impact factor: 6.709

Review 4.  Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson's disease.

Authors:  Elena Coccia; Tim Ahfeldt
Journal:  Stem Cell Res Ther       Date:  2021-04-29       Impact factor: 6.832

Review 5.  3D hydrogel models of the neurovascular unit to investigate blood-brain barrier dysfunction.

Authors:  Geoffrey Potjewyd; Katherine A B Kellett; Nigel M Hooper
Journal:  Neuronal Signal       Date:  2021-11-09

Review 6.  An Integrated Approach to Studying Rare Neuromuscular Diseases Using Animal and Human Cell-Based Models.

Authors:  Timothy J Hines; Cathleen Lutz; Stephen A Murray; Robert W Burgess
Journal:  Front Cell Dev Biol       Date:  2022-01-03
  6 in total

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