Literature DB >> 33828211

Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy.

Pablo Torres-Sánchez1, Ignacio Porras2, Nataliya Ramos-Chernenko1, Fernando Arias de Saavedra1, Javier Praena1.   

Abstract

Boron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.

Entities:  

Year:  2021        PMID: 33828211     DOI: 10.1038/s41598-021-87305-9

Source DB:  PubMed          Journal:  Sci Rep        ISSN: 2045-2322            Impact factor:   4.379


  16 in total

1.  Monte Carlo model of the Studsvik BNCT clinical beam: description and validation.

Authors:  Valerio Giusti; Per M Munck af Rosenschöld; Kurt Sköld; Bruno Montagnini; Jacek Capala
Journal:  Med Phys       Date:  2003-12       Impact factor: 4.071

2.  Renovation of epithermal neutron beam for BNCT at THOR.

Authors:  Y-W H Liu; T T Huang; S H Jiang; H M Liu
Journal:  Appl Radiat Isot       Date:  2004-11       Impact factor: 1.513

3.  Optimization of an accelerator-based epithermal neutron source for neutron capture therapy.

Authors:  O E Kononov; V N Kononov; M V Bokhovko; V V Korobeynikov; A N Soloviev; A S Sysoev; I A Gulidov; W T Chu; D W Nigg
Journal:  Appl Radiat Isot       Date:  2004-11       Impact factor: 1.513

4.  Designing accelerator-based epithermal neutron beams for boron neutron capture therapy.

Authors:  D L Bleuel; R J Donahue; B A Ludewigt; J Vujic
Journal:  Med Phys       Date:  1998-09       Impact factor: 4.071

5.  Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS).

Authors:  H Tanaka; Y Sakurai; M Suzuki; S Masunaga; T Mitsumoto; K Fujita; G Kashino; Y Kinashi; Y Liu; M Takada; K Ono; A Maruhashi
Journal:  Appl Radiat Isot       Date:  2011-03-21       Impact factor: 1.513

6.  Neutron spectral fluence measurements using a Bonner sphere spectrometer in the development of the iBNCT accelerator-based neutron source.

Authors:  Akihiko Masuda; Tetsuro Matsumoto; Kenta Takada; Takahiro Onishi; Kohei Kotaki; Hidenori Sugimoto; Hiroaki Kumada; Hideki Harano; Takeji Sakae
Journal:  Appl Radiat Isot       Date:  2017-05-10       Impact factor: 1.513

7.  Present status of Accelerator-Based BNCT.

Authors:  Andres Juan Kreiner; Javier Bergueiro; Daniel Cartelli; Matias Baldo; Walter Castell; Javier Gomez Asoia; Javier Padulo; Juan Carlos Suárez Sandín; Marcelo Igarzabal; Julian Erhardt; Daniel Mercuri; Alejandro A Valda; Daniel M Minsky; Mario E Debray; Hector R Somacal; María Eugenia Capoulat; María S Herrera; Mariela F Del Grosso; Leonardo Gagetti; Manuel Suarez Anzorena; Nicolas Canepa; Nicolas Real; Marcelo Gun; Hernán Tacca
Journal:  Rep Pract Oncol Radiother       Date:  2014-12-12

8.  Design and construction of an accelerator-based boron neutron capture therapy (AB-BNCT) facility with multiple treatment rooms at the Southern Tohoku BNCT Research Center.

Authors:  Takahiro Kato; Katsumi Hirose; Hiroki Tanaka; Toshinori Mitsumoto; Tomoaki Motoyanagi; Kazuhiro Arai; Takaomi Harada; Akihiko Takeuchi; Ryohei Kato; Satoru Yajima; Yoshihiro Takai
Journal:  Appl Radiat Isot       Date:  2019-10-25       Impact factor: 1.513

9.  Beam shaping assembly design of 7Li(p,n)7Be neutron source for boron neutron capture therapy of deep-seated tumor.

Authors:  L Zaidi; M Belgaid; S Taskaev; R Khelifi
Journal:  Appl Radiat Isot       Date:  2018-05-31       Impact factor: 1.513

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  2 in total

1.  Neutron Source Based on Vacuum Insulated Tandem Accelerator and Lithium Target.

Authors:  Sergey Taskaev; Evgenii Berendeev; Marina Bikchurina; Timofey Bykov; Dmitrii Kasatov; Iaroslav Kolesnikov; Alexey Koshkarev; Aleksandr Makarov; Georgii Ostreinov; Vyacheslav Porosev; Sergey Savinov; Ivan Shchudlo; Evgeniia Sokolova; Igor Sorokin; Tatiana Sycheva; Gleb Verkhovod
Journal:  Biology (Basel)       Date:  2021-04-21

2.  A Boron Delivery Antibody (BDA) with Boronated Specific Residues: New Perspectives in Boron Neutron Capture Therapy from an In Silico Investigation.

Authors:  Alessandro Rondina; Paola Fossa; Alessandro Orro; Luciano Milanesi; Antonella De Palma; Davide Perico; Pier Luigi Mauri; Pasqualina D'Ursi
Journal:  Cells       Date:  2021-11-18       Impact factor: 6.600

  2 in total

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