Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A genetically encoded sensor for measuring serotonin dynamics.

Literature DB >> 33821000

A genetically encoded sensor for measuring serotonin dynamics.

Jinxia Wan^1,2, Wanling Peng³, Xuelin Li^1,2, Tongrui Qian^1,2, Kun Song³, Jianzhi Zeng^1,2,4, Fei Deng^1,2, Suyu Hao^1,2, Jiesi Feng^1,2,4, Peng Zhang⁵, Yajun Zhang⁵, Jing Zou^1,2,6, Sunlei Pan^1,2,4, Mimi Shin⁷, B Jill Venton⁷, J Julius Zhu⁵, Miao Jing⁸, Min Xu³, Yulong Li^9,10,11.

Abstract

Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the release of 5-HT, we developed a genetically encoded G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB5-HT) sensor with high sensitivity, high selectivity, subsecond kinetics and subcellular resolution. GRAB5-HT detects 5-HT release in multiple physiological and pathological conditions in both flies and mice and provides new insights into the dynamics and mechanisms of 5-HT signaling.

Entities: Chemical Species

Mesh：

Substances：

Year: 2021 PMID： 33821000 DOI： 10.1038/s41593-021-00823-7

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

36 in total

1. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.

Authors: Tommaso Patriarchi; Jounhong Ryan Cho; Katharina Merten; Mark W Howe; Aaron Marley; Wei-Hong Xiong; Robert W Folk; Gerard Joey Broussard; Ruqiang Liang; Min Jee Jang; Haining Zhong; Daniel Dombeck; Mark von Zastrow; Axel Nimmerjahn; Viviana Gradinaru; John T Williams; Lin Tian
Journal: Science Date: 2018-05-31 Impact factor: 47.728

2. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.

Authors: Jiesi Feng; Changmei Zhang; Julieta E Lischinsky; Miao Jing; Jingheng Zhou; Huan Wang; Yajun Zhang; Ao Dong; Zhaofa Wu; Hao Wu; Weiyu Chen; Peng Zhang; Jing Zou; S Andrew Hires; J Julius Zhu; Guohong Cui; Dayu Lin; Jiulin Du; Yulong Li
Journal: Neuron Date: 2019-03-25 Impact factor: 17.173

3. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.

Authors: K P Lesch; D Bengel; A Heils; S Z Sabol; B D Greenberg; S Petri; J Benjamin; C R Müller; D H Hamer; D L Murphy
Journal: Science Date: 1996-11-29 Impact factor: 47.728

4. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat.

Authors: C M Portas; B Bjorvatn; S Fagerland; J Grønli; V Mundal; E Sørensen; R Ursin
Journal: Neuroscience Date: 1998-04 Impact factor: 3.590

5. Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain.

Authors: M A Bunin; C Prioleau; R B Mailman; R M Wightman
Journal: J Neurochem Date: 1998-03 Impact factor: 5.372

Review 6. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis.

Authors: R W Fuller
Journal: Life Sci Date: 1994 Impact factor: 5.037

Review 7. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review.

Authors: Meera Vaswani; Farzana Kadar Linda; Subramanyam Ramesh
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2003-02 Impact factor: 5.067

8. A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice.

Authors: Fangmiao Sun; Jianzhi Zeng; Miao Jing; Jingheng Zhou; Jiesi Feng; Scott F Owen; Yichen Luo; Funing Li; Huan Wang; Takashi Yamaguchi; Zihao Yong; Yijing Gao; Wanling Peng; Lizhao Wang; Siyu Zhang; Jiulin Du; Dayu Lin; Min Xu; Anatol C Kreitzer; Guohong Cui; Yulong Li
Journal: Cell Date: 2018-07-12 Impact factor: 41.582

9. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies.

Authors: Miao Jing; Peng Zhang; Guangfu Wang; Jiesi Feng; Lukas Mesik; Jianzhi Zeng; Huoqing Jiang; Shaohua Wang; Jess C Looby; Nick A Guagliardo; Linda W Langma; Ju Lu; Yi Zuo; David A Talmage; Lorna W Role; Paula Q Barrett; Li I Zhang; Minmin Luo; Yan Song; J Julius Zhu; Yulong Li
Journal: Nat Biotechnol Date: 2018-07-09 Impact factor: 54.908

10. Serotonin neurons in the dorsal raphe nucleus encode reward signals.

Authors: Yi Li; Weixin Zhong; Daqing Wang; Qiru Feng; Zhixiang Liu; Jingfeng Zhou; Chunying Jia; Fei Hu; Jiawei Zeng; Qingchun Guo; Ling Fu; Minmin Luo
Journal: Nat Commun Date: 2016-01-28 Impact factor: 14.919

26 in total

1. Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging.

Authors: Chi Ren; Takaki Komiyama
Journal: J Neurosci Date: 2021-04-23 Impact factor: 6.167

2. Dual-Channel Electrochemical Measurements Reveal Rapid Adenosine is Localized in Brain Slices.

Authors: Yuanyu Chang; B Jill Venton
Journal: ACS Chem Neurosci Date: 2022-01-25 Impact factor: 4.418

3. Orthogonally-polarized excitation for improved two-photon and second-harmonic-generation microscopy, applied to neurotransmitter imaging with GPCR-based sensors.

Authors: Mauro Pulin; Kilian E Stockhausen; Olivia A Masseck; Martin Kubitschke; Björn Busse; J Simon Wiegert; Thomas G Oertner
Journal: Biomed Opt Express Date: 2022-01-14 Impact factor: 3.732

A genetically encoded sensor for measuring serotonin dynamics.

1. Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.

2. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.

3. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region.

4. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat.

5. Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain.

Review 6. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis.

Review 7. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review.

8. A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice.

9. A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies.

10. Serotonin neurons in the dorsal raphe nucleus encode reward signals.

1. Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging.

2. Dual-Channel Electrochemical Measurements Reveal Rapid Adenosine is Localized in Brain Slices.

3. Orthogonally-polarized excitation for improved two-photon and second-harmonic-generation microscopy, applied to neurotransmitter imaging with GPCR-based sensors.

Review 4. Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.

Review 5. Neural circuit mechanisms that govern inter-male attack in mice.

6. SSRI antidepressants differentially modulate serotonin reuptake and release in Drosophila.

Review 7. Transgenic mice encoding modern imaging probes: Properties and applications.

Review 8. Advancements in the Quest to Map, Monitor, and Manipulate Neural Circuitry.

9. Observing and Quantifying Fluorescent Reporters.

10. A perspective on astrocyte regulation of neural circuit function and animal behavior.