Bing Luo1, Minjie Sun2, Xingxing Huo3, Yun Wang4. 1. Department of Clinical Laboratory, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230041, China. 2. Department of Operating Room, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230041, China. 3. Department of Scientific Research Center, The Traditional Chinese Medicine Hospital of Anhui province, Hefei, Anhui 230020, China. 4. Department of Hospital Infection Management, Anhui No. 2 Provincial People's Hospital, 1868 Dangshan Road, Hefei, Anhui 230041, China.
Abstract
BACKGROUND: The objective of this study was to investigate the relationship among hypersensitive C-reactive protein to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and the CURB-65 score for community-acquired pneumonia (CAP) severity. METHODS: Clinical data and laboratory indicators of 82 patients with CAP and 40 healthy subjects were retrospectively analysed. The relationship among CAR, FAR, and the severity of CAP was then analysed. RESULTS: CAR and FAR in patients with low-risk CAP were significantly higher than those in the normal control group (P < 0.05). CAR and FAR in patients with medium-high-risk CAP were further increased compared with those in patients with low-risk CAP (P < 0.05). CAR and FAR were positively correlated with hypersensitive C-reactive protein, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and CURB-65 scores (P < 0.05). In the receiver operating characteristic curve for predicting severe CAP, the area under the curve of combining four biomarkers (CAR + FAR + NLR + PLR) was the largest. CAR was also an independent risk factor for severe CAP (OR = 8.789, 95% CI: 1.543-50.064, P = 0.014). CONCLUSIONS: CAR and FAR may be used as the inflammatory markers for CAP severity evaluation.
BACKGROUND: The objective of this study was to investigate the relationship among hypersensitive C-reactive protein to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and the CURB-65 score for community-acquired pneumonia (CAP) severity. METHODS: Clinical data and laboratory indicators of 82 patients with CAP and 40 healthy subjects were retrospectively analysed. The relationship among CAR, FAR, and the severity of CAP was then analysed. RESULTS: CAR and FAR in patients with low-risk CAP were significantly higher than those in the normal control group (P < 0.05). CAR and FAR in patients with medium-high-risk CAP were further increased compared with those in patients with low-risk CAP (P < 0.05). CAR and FAR were positively correlated with hypersensitive C-reactive protein, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and CURB-65 scores (P < 0.05). In the receiver operating characteristic curve for predicting severe CAP, the area under the curve of combining four biomarkers (CAR + FAR + NLR + PLR) was the largest. CAR was also an independent risk factor for severe CAP (OR = 8.789, 95% CI: 1.543-50.064, P = 0.014). CONCLUSIONS: CAR and FAR may be used as the inflammatory markers for CAP severity evaluation.
Authors: Metin Çağdaş; Ibrahim Rencüzoğullari; Süleyman Karakoyun; Yavuz Karabağ; Mahmut Yesin; Inanç Artaç; Doğan Iliş; Öznur Sadioğlu Çağdaş; Aysu Hayriye Tezcan; Halil Ibrahim Tanboğa Journal: Angiology Date: 2017-11-26 Impact factor: 3.619
Authors: Hernán J Zavalaga-Zegarra; Juan J Palomino-Gutierrez; Juan R Ulloque-Badaracco; Melany D Mosquera-Rojas; Enrique A Hernandez-Bustamante; Esteban A Alarcon-Braga; Vicente A Benites-Zapata; Percy Herrera-Añazco; Adrian V Hernandez Journal: Trop Med Infect Dis Date: 2022-08-16
Authors: Juan R Ulloque-Badaracco; Esteban A Alarcon-Braga; Enrique A Hernandez-Bustamante; Ali Al-Kassab-Córdova; Melany D Mosquera-Rojas; Ricardo R Ulloque-Badaracco; Miguel A Huayta-Cortez; Sherelym H Maita-Arauco; Percy Herrera-Añazco; Vicente A Benites-Zapata Journal: Trop Med Infect Dis Date: 2022-07-27