Chunchun Wu1, Lichun Li1, Xue Xiao2, Anyi Sun3, Wenji Lin4, Ailu Li5. 1. Department of Obstetrics and Gynecology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou Fujian Province 362000 PR China. 2. Department of Obstetrics and Gynecology, Medical College of Nanchang University, 330031 Nanchang PR China. 3. Department of Ultrasonography, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou Fujian Province 362000 PR China. 4. Department of Radiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou Fujian Province 362000 PR China. 5. No. 248 Dong Road Quanzhou City Fujian Province 362000 PR China.
Abstract
OBJECTIVES: To explore the risk factors related to regional lymph node metastasis in cervical cancer and analyze the value of independent risk factors in predicting regional lymph node metastasis. METHODS: We retrospectively analyzed the clinical data of 699 patients who underwent surgery for stage IB1-IIA2 cervical cancer in Quanzhou First Hospital affiliated to Fujian Medical University from 2010 to 2016. The patients were divided into metastasis (n = 92) and non-metastasis (n = 607) groups based on the postoperative pathology of regional lymph node status. The relevant clinicopathological features of the metastasis and non-metastasis groups were compared through variance analysis and chi-square tests. Logistic regression was adopted to screen relevant independent risk factors of regional lymph node metastasis. RESULTS: In univariate analysis, International Federation of Gynecology and Obstetrics (FIGO) stages, serum squamous cell carcinoma antigen (SCC-Ag), histological type of squamous carcinoma and maximal tumor diameter were related factors for lymphatic metastasis in patients with cervical cancer. In multivariate analysis, SCC-Ag and histological type of squamous carcinoma were independent prognostic factors for lymphatic metastasis in patients with cervical cancer. Pre-treatment SCC-Ag serum levels, as a predictor of lymph node metastasis of cervical cancer, revealed a sensitivity of 62.07% (95% confidence interval (CI): 51.03-72.62%), specificity of 65.15% (59.07-70.89%), and area under the receiver operating characteristic (ROC) curve of 0.69 (95% CI: 0.61-0.76). CONCLUSIONS: Cervical cancer patients whose pathological type is squamous carcinoma with high levels of SSC-Ag pre-operation are more likely to be diagnosed with regional lymph node metastasis. Standardized lymph node dissection should be implemented during operation.
OBJECTIVES: To explore the risk factors related to regional lymph node metastasis in cervical cancer and analyze the value of independent risk factors in predicting regional lymph node metastasis. METHODS: We retrospectively analyzed the clinical data of 699 patients who underwent surgery for stage IB1-IIA2 cervical cancer in Quanzhou First Hospital affiliated to Fujian Medical University from 2010 to 2016. The patients were divided into metastasis (n = 92) and non-metastasis (n = 607) groups based on the postoperative pathology of regional lymph node status. The relevant clinicopathological features of the metastasis and non-metastasis groups were compared through variance analysis and chi-square tests. Logistic regression was adopted to screen relevant independent risk factors of regional lymph node metastasis. RESULTS: In univariate analysis, International Federation of Gynecology and Obstetrics (FIGO) stages, serum squamous cell carcinoma antigen (SCC-Ag), histological type of squamous carcinoma and maximal tumor diameter were related factors for lymphatic metastasis in patients with cervical cancer. In multivariate analysis, SCC-Ag and histological type of squamous carcinoma were independent prognostic factors for lymphatic metastasis in patients with cervical cancer. Pre-treatment SCC-Ag serum levels, as a predictor of lymph node metastasis of cervical cancer, revealed a sensitivity of 62.07% (95% confidence interval (CI): 51.03-72.62%), specificity of 65.15% (59.07-70.89%), and area under the receiver operating characteristic (ROC) curve of 0.69 (95% CI: 0.61-0.76). CONCLUSIONS: Cervical cancer patients whose pathological type is squamous carcinoma with high levels of SSC-Ag pre-operation are more likely to be diagnosed with regional lymph node metastasis. Standardized lymph node dissection should be implemented during operation.
Authors: T Kamura; T Shigematsu; T Kaku; T Shimamoto; T Saito; K Sakai; M Mitsumoto; H Nakano Journal: Acta Obstet Gynecol Scand Date: 1999-05 Impact factor: 3.636
Authors: Lucas Minig; María Guadalupe Patrono; Nuria Romero; Juan Francisco Rodríguez Moreno; Jesús Garcia-Donas Journal: World J Clin Oncol Date: 2014-05-10