| Literature DB >> 33815878 |
Die Hu1,2, Fangfang Xie1,2, Yongwei Xiao1,2, Chen Lu1, Jianing Zhong1,3, Defa Huang1,4, Jie Chen1,2, Jifu Wei4, Yu Jiang5, Tianyu Zhong1,2,4.
Abstract
Aging is a universal phenomenon in all biological organisms, defined by the loss of reproductive capacity and a progressive decline in fitness. In humans, aging is further associated with an increased incidence of disease conditions. The current aging population has become a primary public burden of the 21st century. Therefore, to delay the aging process and maintain fitness in the aging population, the discovery of novel anti-aging drugs remains an urgent need. In recent years, metformin, a widely used hypoglycemic drug, has attracted growing attention in the field of anti-aging research. Reportedly, numerous studies have indicated that metformin regulates aging-related pathways, possibly delaying the aging process by modulating these pathways. The elucidation of these anti-aging effects may provide insights into the age-retarding potential of metformin. The present review focuses on the predominant molecular mechanisms associated with aging, as well as the anti-aging effects of metformin. copyright:Entities:
Keywords: Insulin-Like Growth Factor I; aging; metformin; oxidative stress; proteostasis
Year: 2021 PMID： 33815878 PMCID： PMC7990352 DOI： 10.14336/AD.2020.0702
Source DB: PubMed Journal: Aging Dis ISSN： 2152-5250 Impact factor: 6.745