Literature DB >> 33813684

Maternal Pragmatic Language Difficulties in the FMR1 Premutation and the Broad Autism Phenotype: Associations with Individual and Family Outcomes.

Jessica Klusek1, Angela John Thurman2, Leonard Abbeduto2.   

Abstract

Broader phenotypes associated with genetic liability, including mild difficulties with pragmatic language skills, have been documented in mothers of children with autism spectrum disorder (ASD) and mothers of children with fragile X syndrome (FXS). This study investigated the relationship between pragmatic difficulties and indicators of maternal well-being and family functioning. Pragmatic difficulty was associated with loneliness in mothers of children with ASD or FXS, and with depression, decreased life satisfaction, and poorer family relationship quality in mothers of children with FXS only. Results inform subtle maternal pragmatic language difficulties as a risk factor that that may contribute to reduced health and well-being, informing tailored support services to better meet the unique needs of families of children with ASD or FXS.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Autism spectrum disorder; Depression; Fragile X premutation; Fragile X syndrome; Loneliness; Social communication

Mesh：

Substances：

Year:  2021        PMID： 33813684      PMCID： PMC8488060          DOI： 10.1007/s10803-021-04980-3

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  102 in total

Review 1.  Systematic review of family functioning in families of children and adolescents with chronic pain.

Authors:  Amy S Lewandowski; Tonya M Palermo; Jennifer Stinson; Susannah Handley; Christine T Chambers
Journal:  J Pain       Date:  2010-11       Impact factor: 5.820

Review 2.  The clinical significance of loneliness: a literature review.

Authors:  Liesl M Heinrich; Eleonora Gullone
Journal:  Clin Psychol Rev       Date:  2006-06-19

3.  Predictors of stress in mothers and fathers of children with fragile X syndrome.

Authors:  Annette McCarthy; Monica Cuskelly; Christina E van Kraayenoord; Jonathan Cohen
Journal:  Res Dev Disabil       Date:  2005-12-19

4.  Pragmatic language impairment and associated behavioural problems.

Authors:  Mieke P Ketelaars; Juliane Cuperus; Kino Jansonius; Ludo Verhoeven
Journal:  Int J Lang Commun Disord       Date:  2010 Mar-Apr       Impact factor: 3.020

5.  Communicative competence in parents of children with autism and parents of children with specific language impairment.

Authors:  Tilla F Ruser; Deborah Arin; Michael Dowd; Sara Putnam; Brian Winklosky; Beth Rosen-Sheidley; Joseph Piven; Bruce Tomblin; Helen Tager-Flusberg; Susan Folstein
Journal:  J Autism Dev Disord       Date:  2006-12-16

6.  Pragmatic Language Features of Mothers With the FMR1 Premutation Are Associated With the Language Outcomes of Adolescents and Young Adults With Fragile X Syndrome.

Authors:  Jessica Klusek; Sara E McGrath; Leonard Abbeduto; Jane E Roberts
Journal:  J Speech Lang Hear Res       Date:  2016-02       Impact factor: 2.297

7.  Defining genetically meaningful language and personality traits in relatives of individuals with fragile X syndrome and relatives of individuals with autism.

Authors:  Molly Losh; Jessica Klusek; Gary E Martin; John Sideris; Morgan Parlier; Joseph Piven
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-06-12       Impact factor: 3.568

Review 8.  A meta-analysis of interventions to reduce loneliness.

Authors:  Christopher M Masi; Hsi-Yuan Chen; Louise C Hawkley; John T Cacioppo
Journal:  Pers Soc Psychol Rev       Date:  2010-08-17

9.  Can the Children's Communication Checklist differentiate between children with autism, children with ADHD, and normal controls?

Authors:  Hilde M Geurts; Sylvie Verté; Jaap Oosterlaan; Herbert Roeyers; Catharina A Hartman; Erik J Mulder; Ina A Berckelaer-Onnes; Joseph A Sergeant
Journal:  J Child Psychol Psychiatry       Date:  2004-11       Impact factor: 8.982

Review 10.  The translation of translational control by FMRP: therapeutic targets for FXS.

Authors:  Jennifer C Darnell; Eric Klann
Journal:  Nat Neurosci       Date:  2013-04-14       Impact factor: 24.884
View more
  4 in total

1.  The Influence of ASD Severity on Parental Overload: The Moderating Role of Parental Well-Being and the ASD Pragmatic Level.

Authors:  Eva M Lira Rodríguez; Rocío Cremallet Pascual; Miguel Puyuelo Sanclemente; Pilar Martín-Hernández; Marta Gil-Lacruz; Ana I Gil-Lacruz
Journal:  Children (Basel)       Date:  2022-05-24

2.  The Phenotypic Profile Associated With the FMR1 Premutation in Women: An Investigation of Clinical-Behavioral, Social-Cognitive, and Executive Abilities.

Authors:  Nell Maltman; Janna Guilfoyle; Kritika Nayar; Gary E Martin; Molly Winston; Joseph C Y Lau; Lauren Bush; Shivani Patel; Michelle Lee; John Sideris; Deborah A Hall; Lili Zhou; Kevin Sharp; Elizabeth Berry-Kravis; Molly Losh
Journal:  Front Psychiatry       Date:  2021-08-06       Impact factor: 5.435

Review 3.  Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer's Disease.

Authors:  Muhammad Shahid Nadeem; Salman Hosawi; Sultan Alshehri; Mohammed M Ghoneim; Syed Sarim Imam; Bibi Nazia Murtaza; Imran Kazmi
Journal:  Biomolecules       Date:  2021-11-04

4.  Mental Health Challenges, Parenting Stress, and Features of the Couple Relationship in Parents of Children With Fragile X Syndrome.

Authors:  Sarah Nelson Potter; Danielle J Harvey; Audra Sterling; Leonard Abbeduto
Journal:  Front Psychiatry       Date:  2022-04-01       Impact factor: 5.435
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.