BACKGROUND & AIMS: Gut microbiota are affected by diet, country, and affect outcomes in cirrhosis. Western diets are associated with dysbiosis. Comparisons with other diets is needed. We aimed to compare cirrhosis patients from the United States with cirrhosis patients from Brazil with respect to diet, microbiota, and impact on hospitalizations. METHODS: Healthy controls and compensated/decompensated outpatients with cirrhosis from the United States and Brazil underwent dietary recall and stool for 16S ribosomal RNA sequencing. Demographics and medications/cirrhosis details were compared within and between countries. Patients with cirrhosis were followed up for 90-day hospitalizations. Regression for Shannon diversity was performed within cirrhosis. Regression for hospitalizations adjusting for clinical and microbial variables was performed. RESULTS: Model for end-stage liver disease (MELD), diabetes, ascites, and albumin were similar, but more Americans were men, had higher hepatic encephalopathy and alcohol/hepatitis C etiology, with lower nonalcoholic fatty liver disease than Brazilians. Brazilians had higher cereal, rice, and yogurt intake vs the United States. As disease progressed, cereals, rice/beans, coffee, and chocolate consumption was reduced. Microbial diversity was higher in Brazilians. Within cirrhosis, high diversity was related to Brazilian origin (P < .0001), age, and cereal intake (P = .05), while high MELD scores (P = .009) and ascites (P = .05) did the reverse. Regardless of stage, beneficial taxa and taxa associated with grant and yogurt intake were higher (Ruminococcaceae, Christensenellacae, and Prevotellaceae), while pathobionts (Porphyromonadaceae, Sutterellaceae, and Enterobacteriaceae) were lower in Brazilians. More Americans were hospitalized vs Brazilians (P = .002). On regression, MELD (P = .001) and ascites (P = .001) were associated with higher hospitalizations, while chocolate (P = .03) and Brazilian origin (P = .001) were associated with lower hospitalizations with/without microbiota inclusion. CONCLUSIONS: Brazilian cirrhotic patients follow a diet richer in cereals and yogurt, which is associated with higher microbial diversity and beneficial microbiota and could contribute toward lower hospitalizations compared with a Western-diet-consuming American cohort.
BACKGROUND & AIMS: Gut microbiota are affected by diet, country, and affect outcomes in cirrhosis. Western diets are associated with dysbiosis. Comparisons with other diets is needed. We aimed to compare cirrhosis patients from the United States with cirrhosis patients from Brazil with respect to diet, microbiota, and impact on hospitalizations. METHODS: Healthy controls and compensated/decompensated outpatients with cirrhosis from the United States and Brazil underwent dietary recall and stool for 16S ribosomal RNA sequencing. Demographics and medications/cirrhosis details were compared within and between countries. Patients with cirrhosis were followed up for 90-day hospitalizations. Regression for Shannon diversity was performed within cirrhosis. Regression for hospitalizations adjusting for clinical and microbial variables was performed. RESULTS: Model for end-stage liver disease (MELD), diabetes, ascites, and albumin were similar, but more Americans were men, had higher hepatic encephalopathy and alcohol/hepatitis C etiology, with lower nonalcoholic fatty liver disease than Brazilians. Brazilians had higher cereal, rice, and yogurt intake vs the United States. As disease progressed, cereals, rice/beans, coffee, and chocolate consumption was reduced. Microbial diversity was higher in Brazilians. Within cirrhosis, high diversity was related to Brazilian origin (P < .0001), age, and cereal intake (P = .05), while high MELD scores (P = .009) and ascites (P = .05) did the reverse. Regardless of stage, beneficial taxa and taxa associated with grant and yogurt intake were higher (Ruminococcaceae, Christensenellacae, and Prevotellaceae), while pathobionts (Porphyromonadaceae, Sutterellaceae, and Enterobacteriaceae) were lower in Brazilians. More Americans were hospitalized vs Brazilians (P = .002). On regression, MELD (P = .001) and ascites (P = .001) were associated with higher hospitalizations, while chocolate (P = .03) and Brazilian origin (P = .001) were associated with lower hospitalizations with/without microbiota inclusion. CONCLUSIONS: Brazilian cirrhotic patients follow a diet richer in cereals and yogurt, which is associated with higher microbial diversity and beneficial microbiota and could contribute toward lower hospitalizations compared with a Western-diet-consuming American cohort.
Authors: Desirrê Morais Dias; Nikolai Kolba; Jon J Hart; Michelle Ma; Sybil T Sha; Naveena Lakshmanan; Marilia Regini Nutti; Hércia Stampini Duarte Martino; Raymond P Glahn; Elad Tako Journal: Food Res Int Date: 2019-04-27 Impact factor: 6.475
Authors: Patrick M Smith; Michael R Howitt; Nicolai Panikov; Monia Michaud; Carey Ann Gallini; Mohammad Bohlooly-Y; Jonathan N Glickman; Wendy S Garrett Journal: Science Date: 2013-07-04 Impact factor: 47.728
Authors: John B Whitfield; Steven Masson; Suthat Liangpunsakul; Sebastian Mueller; Guruprasad P Aithal; Florian Eyer; Dermot Gleeson; Andrew Thompson; Felix Stickel; Michael Soyka; Beat Muellhaupt; Ann K Daly; Heather J Cordell; Tatiana Foroud; Lawrence Lumeng; Munir Pirmohamed; Bertrand Nalpas; Jean-Marc Jacquet; Romain Moirand; Pierre Nahon; Sylvie Naveau; Pascal Perney; Paul S Haber; Helmut K Seitz; Christopher P Day; Philippe Mathurin; Timothy R Morgan; Devanshi Seth Journal: Am J Gastroenterol Date: 2021-01-01 Impact factor: 10.864
Authors: Veronika B Dubinkina; Alexander V Tyakht; Vera Y Odintsova; Konstantin S Yarygin; Boris A Kovarsky; Alexander V Pavlenko; Dmitry S Ischenko; Anna S Popenko; Dmitry G Alexeev; Anastasiya Y Taraskina; Regina F Nasyrova; Evgeny M Krupitsky; Nino V Shalikiani; Igor G Bakulin; Petr L Shcherbakov; Lyubov O Skorodumova; Andrei K Larin; Elena S Kostryukova; Rustam A Abdulkhakov; Sayar R Abdulkhakov; Sergey Y Malanin; Ruzilya K Ismagilova; Tatiana V Grigoryeva; Elena N Ilina; Vadim M Govorun Journal: Microbiome Date: 2017-10-17 Impact factor: 14.650
Authors: I Jane Cox; Ramazan Idilman; Andrew Fagan; Dilara Turan; Lola Ajayi; Adrien D Le Guennec; Simon D Taylor-Robinson; Fatih Karakaya; Edith Gavis; R Andrew Atkinson; Roger Williams; Masoumeh Sikaroodi; Shahzor Nizam; Patrick M Gillevet; Jasmohan S Bajaj Journal: Liver Int Date: 2019-10-07 Impact factor: 8.754
Authors: Karolina S Jabbar; Brendan Dolan; Lisbeth Eklund; Catharina Wising; Anna Ermund; Åsa Johansson; Hans Törnblom; Magnus Simren; Gunnar C Hansson Journal: Gut Date: 2020-11-11 Impact factor: 23.059
Authors: Jasmohan S Bajaj; Andrew Fagan; Sara McGeorge; Richard K Sterling; Shari Rogal; Masoumeh Sikaroodi; Patrick M Gillevet Journal: Clin Transl Gastroenterol Date: 2022-06-01 Impact factor: 4.396