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Literature DB >> 33812776

Interrogating immune cells and cancer with CRISPR-Cas9.

Frank A Buquicchio¹, Ansuman T Satpathy².

Abstract

CRISPR-Cas9 technologies have transformed the study of genetic pathways governing cellular differentiation and function. Recent advances have adapted these methods to immune cells, which has accelerated the pace of functional genomics in immunology and enabled new avenues for the design of cellular immunotherapies for cancer. In this review, we summarize recent developments in CRISPR-Cas9 technology and discuss how they have been leveraged to discover and manipulate novel genetic regulators of the immune system. We envision that these results will provide a valuable resource to aid in the design, implementation, and interpretation of CRISPR-Cas9-based screens in immunology and immuno-oncology.

Entities: Chemical

Mesh：

Year: 2021 PMID： 33812776 PMCID： PMC9345562 DOI： 10.1016/j.it.2021.03.003

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 19.709

94 in total

1. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.

Authors: Deng Pan; Aya Kobayashi; Peng Jiang; Lucas Ferrari de Andrade; Rong En Tay; Adrienne M Luoma; Daphne Tsoucas; Xintao Qiu; Klothilda Lim; Prakash Rao; Henry W Long; Guo-Cheng Yuan; John Doench; Myles Brown; X Shirley Liu; Kai W Wucherpfennig
Journal: Science Date: 2018-01-04 Impact factor: 47.728

2. Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.

Authors: Evan Z Macosko; Anindita Basu; Rahul Satija; James Nemesh; Karthik Shekhar; Melissa Goldman; Itay Tirosh; Allison R Bialas; Nolan Kamitaki; Emily M Martersteck; John J Trombetta; David A Weitz; Joshua R Sanes; Alex K Shalek; Aviv Regev; Steven A McCarroll
Journal: Cell Date: 2015-05-21 Impact factor: 41.582

3. High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells.

Authors: Yuexin Zhou; Shiyou Zhu; Changzu Cai; Pengfei Yuan; Chunmei Li; Yanyi Huang; Wensheng Wei
Journal: Nature Date: 2014-04-09 Impact factor: 49.962

4. CRISPR-based functional genomics in human dendritic cells.

Authors: Marco Jost; Amy N Jacobson; Jeffrey A Hussmann; Giana Cirolia; Michael A Fischbach; Jonathan S Weissman
Journal: Elife Date: 2021-04-27 Impact factor: 8.140

5. Highly efficient Cas9-mediated transcriptional programming.

Authors: Alejandro Chavez; Jonathan Scheiman; Suhani Vora; Benjamin W Pruitt; Marcelle Tuttle; Eswar P R Iyer; Shuailiang Lin; Samira Kiani; Christopher D Guzman; Daniel J Wiegand; Dmitry Ter-Ovanesyan; Jonathan L Braff; Noah Davidsohn; Benjamin E Housden; Norbert Perrimon; Ron Weiss; John Aach; James J Collins; George M Church
Journal: Nat Methods Date: 2015-03-02 Impact factor: 28.547

6. Sequence determinants of improved CRISPR sgRNA design.

Authors: Han Xu; Tengfei Xiao; Chen-Hao Chen; Wei Li; Clifford A Meyer; Qiu Wu; Di Wu; Le Cong; Feng Zhang; Jun S Liu; Myles Brown; X Shirley Liu
Journal: Genome Res Date: 2015-06-10 Impact factor: 9.043

7. Pooled CRISPR screening with single-cell transcriptome readout.

Authors: André F Rendeiro; Christian Schmidl; Paul Datlinger; Thomas Krausgruber; Peter Traxler; Johanna Klughammer; Linda C Schuster; Amelie Kuchler; Donat Alpar; Christoph Bock
Journal: Nat Methods Date: 2017-01-18 Impact factor: 28.547

8. Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors.

Authors: Beau R Webber; Cara-Lin Lonetree; Mitchell G Kluesner; Matthew J Johnson; Emily J Pomeroy; Miechaleen D Diers; Walker S Lahr; Garrett M Draper; Nicholas J Slipek; Branden A Smeester; Klaus N Lovendahl; Amber N McElroy; Wendy R Gordon; Mark J Osborn; Branden S Moriarity
Journal: Nat Commun Date: 2019-11-19 Impact factor: 14.919

9. CRISPR RNA-guided activation of endogenous human genes.

Authors: Morgan L Maeder; Samantha J Linder; Vincent M Cascio; Yanfang Fu; Quan H Ho; J Keith Joung
Journal: Nat Methods Date: 2013-07-25 Impact factor: 28.547

10. RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

Authors: Pablo Perez-Pinera; D Dewran Kocak; Christopher M Vockley; Andrew F Adler; Ami M Kabadi; Lauren R Polstein; Pratiksha I Thakore; Katherine A Glass; David G Ousterout; Kam W Leong; Farshid Guilak; Gregory E Crawford; Timothy E Reddy; Charles A Gersbach
Journal: Nat Methods Date: 2013-07-25 Impact factor: 28.547

2 in total

Review 1. Common computational tools for analyzing CRISPR screens.

Authors: Medina Colic; Traver Hart
Journal: Emerg Top Life Sci Date: 2021-12-21

2. CRISPR-surfaceome: An online tool for designing highly efficient sgRNAs targeting cell surface proteins.

Authors: Hong Mei; Qian Gu; Wei Wang; Yu Meng; Lichun Jiang; Jia Liu
Journal: Comput Struct Biotechnol J Date: 2022-07-18 Impact factor: 6.155

2 in total