Literature DB >> 3380854

Effect of L-carnitine derivatives on heart mitochondrial damage induced by lipid peroxidation.

R Ferrari1, G Ciampalini, G Agnoletti, A Cargnoni, C Ceconi, O Visioli.   

Abstract

We have incubated heart mitochondria with ferrous ions as catalyst of lipid peroxidation. Ferrous ions induced an increase of malondialdehyde formation and a reduction of mitochondrial oxygen consuming and calcium transporting capacities. L-Carnitine and Acetyl-L-Carnitine failed to prevent mitochondrial damage. Propionyl-L-Carnitine significantly improved mitochondrial function, but failed to reduce malondialdehyde formation. This protective effect was specific for Propionyl-L-Carnitine as propionic acid and L-Carnitine did not modify mitochondrial damage.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3380854     DOI： 10.1016/s0031-6989(88)80005-5

Source DB:  PubMed          Journal:  Pharmacol Res Commun        ISSN： 0031-6989


  11 in total

Review 1.  Oxidative stress in phenylketonuria: what is the evidence?

Authors:  Graziela S Ribas; Angela Sitta; Moacir Wajner; Carmen R Vargas
Journal:  Cell Mol Neurobiol       Date:  2011-04-23       Impact factor: 5.046

2.  The effect of propionyl-L-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondria.

Authors:  R Ferrari; C Ceconi; A Cargnoni; E Pasini; G M Boffa; S Curello; O Visioli
Journal:  Cardiovasc Drugs Ther       Date:  1991-02       Impact factor: 3.727

3.  The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model.

Authors:  Ibrahim Kocer; Seyithan Taysi; Mustafa Vecdi Ertekin; Ihsan Karslioglu; Akcahan Gepdiremen; Orhan Sezen; Korkmaz Serifoglu
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2006-08-17       Impact factor: 3.117

4.  Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage.

Authors:  R Ferrari; C Ceconi; S Curello; E Pasini; O Visioli
Journal:  Mol Cell Biochem       Date:  1989 Jun 27-Jul 24       Impact factor: 3.396

5.  Effect of D,L-carnitine on the response of the isolated heart of the rat to ischaemia and reperfusion: relation to mitochondrial function.

Authors:  J M Duan; M Karmazyn
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

6.  L-carnitine reduces malondialdehyde concentrations in isolated rat hearts in dependence on perfusion conditions.

Authors:  H Löster; U Böhm
Journal:  Mol Cell Biochem       Date:  2001-01       Impact factor: 3.396

7.  L-carnitine blood levels and oxidative stress in treated phenylketonuric patients.

Authors:  Angela Sitta; Alethéa G Barschak; Marion Deon; Jurema F de Mari; Amanda T Barden; Camila S Vanzin; Giovana B Biancini; Ida V D Schwartz; Moacir Wajner; Carmen R Vargas
Journal:  Cell Mol Neurobiol       Date:  2008-09-24       Impact factor: 5.046

8.  Effects of propionate on mechanical and metabolic performance in aerobic rat hearts.

Authors:  H Bolukoglu; S H Nellis; A J Liedtke
Journal:  Cardiovasc Drugs Ther       Date:  1991-02       Impact factor: 3.727

9.  Effects of some L-carnitine derivatives on heart membrane ATPases.

Authors:  N S Dhalla; F Kolár; K R Shah; R Ferrari
Journal:  Cardiovasc Drugs Ther       Date:  1991-02       Impact factor: 3.727

10.  Effects of L-carnitine on mechanical recovery of isolated rat hearts in relation to the perfusion with glucose and palmitate.

Authors:  H Löster; M Punzel
Journal:  Mol Cell Biochem       Date:  1998-08       Impact factor: 3.396
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.