Literature DB >> 2779535

Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage.

R Ferrari1, C Ceconi, S Curello, E Pasini, O Visioli.   

Abstract

Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10(-7) M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionic acid did not modify myocardial damage.

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Year:  1989        PMID： 2779535     DOI： 10.1007/BF00223438

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  22 in total

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Journal:  Anal Biochem       Date:  1968-10-24       Impact factor: 3.365

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Journal:  Am J Cardiol       Date:  1979-02       Impact factor: 2.778

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Journal:  J Lab Clin Med       Date:  1967-07

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Authors:  S Curello; C Ceconi; A Cargnoni; A Cornacchiari; R Ferrari; A Albertini
Journal:  Clin Chem       Date:  1987-08       Impact factor: 8.327

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Journal:  Int J Cardiol       Date:  1984-02       Impact factor: 4.164

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Journal:  Thorac Cardiovasc Surg       Date:  1980-08       Impact factor: 1.827

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Journal:  Cardiovasc Res       Date:  1986-07       Impact factor: 10.787
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  9 in total

1.  Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart.

Authors:  R Ferrari; E Pasini; E Condorelli; A Boraso; R Lisciani; A Marzo; O Visiou
Journal:  Cardiovasc Drugs Ther       Date:  1991-02       Impact factor: 3.727

Review 2.  Propionyl-CoA carboxylase - A review.

Authors:  Parith Wongkittichote; Nicholas Ah Mew; Kimberly A Chapman
Journal:  Mol Genet Metab       Date:  2017-10-07       Impact factor: 4.797

3.  Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy.

Authors:  H Löster; T Keller; J Grommisch; W Gründer
Journal:  Mol Cell Biochem       Date:  1999-10       Impact factor: 3.396

4.  Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: effects of insulin and Schisandrin B treatment.

Authors:  D H Mak; K M Ko
Journal:  Mol Cell Biochem       Date:  1997-10       Impact factor: 3.396

5.  Cerebral blood flow and metabolism in children with severe head injury. Part 1: Relation to age, Glasgow coma score, outcome, intracranial pressure, and time after injury.

Authors:  P M Sharples; A G Stuart; D S Matthews; A Aynsley-Green; J A Eyre
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-02       Impact factor: 10.154

6.  Effect of propionyl-L-carnitine in a rat model of peripheral arteriopathy: a functional, histologic, and NMR spectroscopic study.

Authors:  N Corsico; A Nardone; M R Lucreziotti; L G Spagnoli; D Pesce; T Aureli; M E Di Cocco; A Miccheli; F Conti; E Arrigoni Martelli
Journal:  Cardiovasc Drugs Ther       Date:  1993-04       Impact factor: 3.727

7.  Protection of the ischemic diabetic heart by L-propionylcarnitine therapy.

Authors:  D J Paulson; A L Shug; J Zhao
Journal:  Mol Cell Biochem       Date:  1992-10-21       Impact factor: 3.396

8.  Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat heart.

Authors:  R Motterlini; M Samaja; M Tarantola; R Micheletti; G Bianchi
Journal:  Mol Cell Biochem       Date:  1992-10-21       Impact factor: 3.396

9.  Effects of propionyl-L-carnitine on ischemia-reperfusion injury in hamster cheek pouch microcirculation.

Authors:  Dominga Lapi; Lina Sabatino; Giovanna Giuseppina Altobelli; Paolo Mondola; Vincenzo Cimini; Antonio Colantuoni
Journal:  Front Physiol       Date:  2010-10-19       Impact factor: 4.566
  9 in total

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