| Literature DB >> 33803104 |
Domenico Umberto De Rose1, Alessandra Santisi1, Maria Paola Ronchetti1, Ludovica Martini1, Lisa Serafini2, Pasqua Betta3, Marzia Maino4, Francesco Cavigioli5, Ilaria Cocchi5, Lorenza Pugni6, Elvira Bonanno7, Chryssoula Tzialla8, Mario Giuffrè9, Jenny Bua10, Benedetta Della Torre11, Giovanna Nardella12, Danila Mazzeo13, Paolo Manzoni14, Andrea Dotta1, Pietro Bagolan15, Cinzia Auriti1.
Abstract
Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.Entities:
Keywords: antifungal prophylaxis; invasive Candida infections; invasive fungal infections; neonatal surgery; newborns; surgery
Year: 2021 PMID： 33803104 PMCID： PMC7999498 DOI： 10.3390/pathogens10030319
Source DB: PubMed Journal: Pathogens ISSN： 2076-0817