Literature DB >> 33796559

Excellent Response of Dermatophytoma and Nail Splitting to Nail Plate Debridement Plus Topical Ciclopirox Olamine 1% Solution.

Hamed Mohamed Abdo1.   

Abstract

Onychomycosis often presents as thickened, discolored nails. Usually, one or both great toenails are affected. Eventually, the nail plate becomes friable and may split and break up, often due to trauma or invasion of the plate by dermatophytes that have keratolytic properties. Dermatophytoma is a unique feature of onychomycosis that occurred by abundant fungal filaments and spores forming a fungal ball under the nail plate. It is often refractory to traditional therapy. Based on the clinical and mycological examination, a case of onychomycosis in a 45-year-old woman presented as dermatophytoma with longitudinal nail splitting caused by Trichophyton rubrum is presented. The case was successfully treated with nail plate debridement plus topical ciclopirox olamine 1% solution. Nail debridement was performed using a 15-scalpel blade to remove the affected nail portion with the underlying subungual debris to enhance the effect of topical ciclopirox 1% solution which was then applied 3 times daily to the debrided area. Follow-up visits with nail photography were planned every 2 weeks after the procedure to check treatment progress. A complete clinical resolution was achieved after 5 months. This treatment option can be advocated for similar nail conditions avoiding unnecessary and expensive lines of treatment.
Copyright © 2020 by S. Karger AG, Basel.

Entities:  

Keywords:  Dermatophytoma; Nail debridement; Nail splitting; Onychomycosis; Topical 1% Ciclopirox olamine; Trichophyton rubrum

Year:  2020        PMID: 33796559      PMCID: PMC7991492          DOI: 10.1159/000512037

Source DB:  PubMed          Journal:  Skin Appendage Disord        ISSN: 2296-9160


  14 in total

1.  Dermatophytoma: Recalcitrance to treatment because of existence of fungal biofilm.

Authors:  Craig N Burkhart; Craig G Burkhart; Aditya K Gupta
Journal:  J Am Acad Dermatol       Date:  2002-10       Impact factor: 11.527

2.  Dermatophytoma: description of 7 cases.

Authors:  Erick Martinez-Herrera; Gabriela Moreno-Coutiño; Ramon F Fernández-Martínez; Justin Finch; Roberto Arenas
Journal:  J Am Acad Dermatol       Date:  2012-06       Impact factor: 11.527

3.  Successful Treatment of Dermatophytomas in 19 Patients Using Efinaconazole 10% Solution.

Authors:  Casey Wang; Wendy Cantrell; Theresa Canavan; Boni Elewski
Journal:  Skin Appendage Disord       Date:  2019-03-20

4.  Prevalence and epidemiology of onychomycosis in patients visiting physicians' offices: a multicenter canadian survey of 15,000 patients.

Authors:  A K Gupta; H C Jain; C W Lynde; P Macdonald; E A Cooper; R C Summerbell
Journal:  J Am Acad Dermatol       Date:  2000-08       Impact factor: 11.527

5.  Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis.

Authors:  A K Gupta; P Fleckman; R Baran
Journal:  J Am Acad Dermatol       Date:  2000-10       Impact factor: 11.527

6.  Ciclopirox 8% HPCH Nail Lacquer in the Treatment of Mild-to-Moderate Onychomycosis: A Randomized, Double-Blind Amorolfine Controlled Study Using a Blinded Evaluator.

Authors:  Matilde Iorizzo; Ilona Hartmane; Andra Derveniece; Ingmars Mikazans
Journal:  Skin Appendage Disord       Date:  2015-11-07

Review 7.  Onychomycosis: Current trends in diagnosis and treatment.

Authors:  Dyanne P Westerberg; Michael J Voyack
Journal:  Am Fam Physician       Date:  2013-12-01       Impact factor: 3.292

8.  Prognostic factors for cure following treatment of onychomycosis.

Authors:  B Sigurgeirsson
Journal:  J Eur Acad Dermatol Venereol       Date:  2009-11-19       Impact factor: 6.166

9.  Efficacy of ciclopiroxolamine 1% cream in onychomycosis and tinea pedis.

Authors:  Y C Wu; M T Chuan; Y C Lü
Journal:  Mycoses       Date:  1991 Jan-Feb       Impact factor: 4.377

Review 10.  Treatment and management strategies of onychomycosis.

Authors:  R Aggarwal; M Targhotra; B Kumar; P K Sahoo; M K Chauhan
Journal:  J Mycol Med       Date:  2020-03-14       Impact factor: 2.391

View more
  1 in total

Review 1.  Dermatophytomas: Clinical Overview and Treatment.

Authors:  Aditya K Gupta; Tong Wang; Elizabeth A Cooper
Journal:  J Fungi (Basel)       Date:  2022-07-19
  1 in total

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