Jacob Uth1,2, Bjørn Fristrup2, Victor Sørensen1,3, Eva Wulff Helge4, Maja Kjaergaard Christensen4, Julie Boye Kjaergaard4, Trine Kjeldgaard Møller2, Jørn Wulff Helge5, Niklas Rye Jørgensen3,6, Mikael Rørth7,8, Eva Soelberg Vadstrup8, Peter Krustrup2,9. 1. University Hospitals Centre for Health Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 2. Section of Sport and Health Sciences, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. 3. Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 4. Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. 5. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. 6. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 7. Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark. 8. Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 9. Danish Institute for Advanced Study (DIAS), University of Southern Denmark, Odense, Denmark.
Abstract
PURPOSE: To examine efficacy of 12 months Football Fitness offered twice per week on bone mineral density (BMD), bone turnover markers (BTM), postural balance, muscle strength, and body composition in women treated for early-stage breast cancer (BC). METHODS:Women treated for early-stage BC were randomized to Football Fitness (FFG, n = 46) or control (CON, n = 22) in a 2:1 ratio for 12 months, with assessments performed at baseline, 6 months and 12 months. Outcomes were total body-, lumbar spine- and proximal femur BMD, total body lean and fat mass, leg muscle strength, postural balance, and plasma amino-terminal propeptide of type 1 procollagen (P1NP), osteocalcin, and C-terminal telopeptide of type 1 collagen (CTX). Intention-to-treat (ITT) analyses and per-protocol analyses (≥50% attendance in FFG) were performed using linear mixed models. RESULTS:Participants in FFG completing the 12-month intervention (n = 33) attended 0.8 (SD = 0.4) sessions per week. Intention to treat analysis of mean changes over 12 months showed significant differences (p<.05) in L1-L4 BMD (0.029 g/cm2 , 95%CI: 0.001 to 0.057), leg press strength (7.2 kg, 95%CI: 0.1 to 14.3), and postural balance (-4.3 n need of support, 95%CI: -8.0 to -0.7) favoring FFG compared to CON. In the per-protocol analyses, L1-L4 and trochanter major BMD were improved (p = .012 and .030, respectively) in FFG compared with CON. No differences were observed between groups in BTMs in the ITT or per protocol analyses. CONCLUSION: One year of Football Fitness training may improve L1-L4 BMD, leg muscle strength, and postural balance in women treated for early-stage breast cancer.
RCT Entities:
PURPOSE: To examine efficacy of 12 months Football Fitness offered twice per week on bone mineral density (BMD), bone turnover markers (BTM), postural balance, muscle strength, and body composition in women treated for early-stage breast cancer (BC). METHODS:Women treated for early-stage BC were randomized to Football Fitness (FFG, n = 46) or control (CON, n = 22) in a 2:1 ratio for 12 months, with assessments performed at baseline, 6 months and 12 months. Outcomes were total body-, lumbar spine- and proximal femur BMD, total body lean and fat mass, leg muscle strength, postural balance, and plasma amino-terminal propeptide of type 1 procollagen (P1NP), osteocalcin, and C-terminal telopeptide of type 1 collagen (CTX). Intention-to-treat (ITT) analyses and per-protocol analyses (≥50% attendance in FFG) were performed using linear mixed models. RESULTS:Participants in FFG completing the 12-month intervention (n = 33) attended 0.8 (SD = 0.4) sessions per week. Intention to treat analysis of mean changes over 12 months showed significant differences (p<.05) in L1-L4 BMD (0.029 g/cm2 , 95%CI: 0.001 to 0.057), leg press strength (7.2 kg, 95%CI: 0.1 to 14.3), and postural balance (-4.3 n need of support, 95%CI: -8.0 to -0.7) favoring FFG compared to CON. In the per-protocol analyses, L1-L4 and trochanter major BMD were improved (p = .012 and .030, respectively) in FFG compared with CON. No differences were observed between groups in BTMs in the ITT or per protocol analyses. CONCLUSION: One year of Football Fitness training may improve L1-L4 BMD, leg muscle strength, and postural balance in women treated for early-stage breast cancer.
Authors: Magni Mohr; Tórur Sjúrðarson; Eli N Leifsson; Morten B Randers; Nikolas Sten Knudsen; Manuel Mounir Demetry Thomasen; Jeppe Panduro; Malte Nejst Larsen; Thomas Bull Andersen; Peter Krustrup Journal: Biomed Res Int Date: 2022-03-17 Impact factor: 3.411