Literature DB >> 33792914

Testing for association in multiview network data.

Lucy L Gao1, Daniela Witten2, Jacob Bien3.   

Abstract

In this paper, we consider data consisting of multiple networks, each composed of a different edge set on a common set of nodes. Many models have been proposed for the analysis of such multiview network data under the assumption that the data views are closely related. In this paper, we provide tools for evaluating this assumption. In particular, we ask: given two networks that each follow a stochastic block model, is there an association between the latent community memberships of the nodes in the two networks? To answer this question, we extend the stochastic block model for a single network view to the two-view setting, and develop a new hypothesis test for the null hypothesis that the latent community memberships in the two data views are independent. We apply our test to protein-protein interaction data from the HINT database. We find evidence of a weak association between the latent community memberships of proteins defined with respect to binary interaction data and the latent community memberships of proteins defined with respect to cocomplex association data. We also extend this proposal to the setting of a network with node covariates. The proposed methods extend readily to three or more network/multivariate data views.
© 2021 The International Biometric Society.

Entities:  

Keywords:  community detection; data integration; multiview data; node covariates; stochastic block model

Mesh:

Substances:

Year:  2021        PMID: 33792914      PMCID: PMC8484362          DOI: 10.1111/biom.13464

Source DB:  PubMed          Journal:  Biometrics        ISSN: 0006-341X            Impact factor:   1.701


  13 in total

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2.  Stochastic blockmodels and community structure in networks.

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Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2011-01-21

3.  Are clusterings of multiple data views independent?

Authors:  Lucy L Gao; Jacob Bien; Daniela Witten
Journal:  Biostatistics       Date:  2020-10-01       Impact factor: 5.899

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Authors:  Yong Chen; Kung-Yee Liang
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5.  Covariate-assisted spectral clustering.

Authors:  N Binkiewicz; J T Vogelstein; K Rohe
Journal:  Biometrika       Date:  2017-03-19       Impact factor: 2.445

6.  LATENT SPACE MODELS FOR MULTIVIEW NETWORK DATA.

Authors:  Michael Salter-Townshend; Tyler H McCormick
Journal:  Ann Appl Stat       Date:  2017-10-05       Impact factor: 2.083

7.  Clustering network layers with the strata multilayer stochastic block model.

Authors:  Natalie Stanley; Saray Shai; Dane Taylor; Peter J Mucha
Journal:  IEEE Trans Netw Sci Eng       Date:  2016-03-25

8.  Testing and Modeling Dependencies Between a Network and Nodal Attributes.

Authors:  Bailey K Fosdick; Peter D Hoff
Journal:  J Am Stat Assoc       Date:  2015-11-07       Impact factor: 5.033

9.  Structure and inference in annotated networks.

Authors:  M E J Newman; Aaron Clauset
Journal:  Nat Commun       Date:  2016-06-16       Impact factor: 14.919

10.  HINT: High-quality protein interactomes and their applications in understanding human disease.

Authors:  Jishnu Das; Haiyuan Yu
Journal:  BMC Syst Biol       Date:  2012-07-30
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