Literature DB >> 33791600

Perspective on the treatment of non-small cell lung cancer in the context of potential SARS-CoV-2 infection during the pandemic.

George Theodoropoulos1, Katerina Albanis1, Medhi Wangpaichitr1,2.   

Abstract

SARS-CoV-2 infections are rising at an alarming rate and various aspects of this pandemic must be quickly and adequately addressed in order to enhance effective healthcare delivery and protect at risk populations such as cancer patients. Preventing Covid-19 infection must be a top system wide priority to avoid mortality, and considerable financial and disease burden. Most cancer patients, and in particular those with tumors resistant to chemotherapy are particularly vulnerable to infection. In this review, we connect potential viral infection of patients with lung tumors that have somewhat quiescence the immune response in the tumor microenvironment and categorize target molecules in metabolism that may be used to identify at risk patients leading to more effective treatment regimens; keeping continuity of therapy and disease prevention during a very tumultuous period of time surrounding the pandemic.

Entities:  

Keywords:  Immunosuppressive; Lung cancer; Metabolism; SARS-CoV-2; Tumor microenvironment

Year:  2021        PMID: 33791600      PMCID: PMC8008947          DOI: 10.14456/jcst.2021.15

Source DB:  PubMed          Journal:  J Curr Sci Technol        ISSN: 2630-0583


  64 in total

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Authors:  Russell G Jones; Craig B Thompson
Journal:  Immunity       Date:  2007-08       Impact factor: 31.745

2.  Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

Authors:  Eric V Dang; Joseph Barbi; Huang-Yu Yang; Dilini Jinasena; Hong Yu; Ying Zheng; Zachary Bordman; Juan Fu; Young Kim; Hung-Rong Yen; Weibo Luo; Karen Zeller; Larissa Shimoda; Suzanne L Topalian; Gregg L Semenza; Chi V Dang; Drew M Pardoll; Fan Pan
Journal:  Cell       Date:  2011-08-25       Impact factor: 41.582

3.  Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer.

Authors:  Kurt A Schalper; Daniel Carvajal-Hausdorf; Joseph McLaughlin; Mehmet Altan; Vamsidhar Velcheti; Patricia Gaule; Miguel F Sanmamed; Lieping Chen; Roy S Herbst; David L Rimm
Journal:  Clin Cancer Res       Date:  2016-07-20       Impact factor: 12.531

4.  Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.

Authors:  Pierre Sonveaux; Frédérique Végran; Thies Schroeder; Melanie C Wergin; Julien Verrax; Zahid N Rabbani; Christophe J De Saedeleer; Kelly M Kennedy; Caroline Diepart; Bénédicte F Jordan; Michael J Kelley; Bernard Gallez; Miriam L Wahl; Olivier Feron; Mark W Dewhirst
Journal:  J Clin Invest       Date:  2008-11-20       Impact factor: 14.808

5.  Coronavirus Disease 2019 (COVID-19) in Italy.

Authors:  Edward Livingston; Karen Bucher
Journal:  JAMA       Date:  2020-03-17       Impact factor: 56.272

6.  Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells.

Authors:  Guo-Yun Chen; Chong Chen; Lizhong Wang; Xing Chang; Pan Zheng; Yang Liu
Journal:  J Immunol       Date:  2008-04-15       Impact factor: 5.422

Review 7.  Tryptophan-degrading enzymes in tumoral immune resistance.

Authors:  Nicolas van Baren; Benoît J Van den Eynde
Journal:  Front Immunol       Date:  2015-02-03       Impact factor: 7.561

8.  Relationship of Metabolic Alterations and PD-L1 Expression in Cisplatin Resistant Lung Cancer.

Authors:  M Wangpaichitr; H Kandemir; Y Y Li; C Wu; Djm Nguyen; L G Feun; M T Kuo; N Savaraj
Journal:  Cell Dev Biol       Date:  2017-04-28

9.  Clinical Characteristics of Coronavirus Disease 2019 in China.

Authors:  Wei-Jie Guan; Zheng-Yi Ni; Yu Hu; Wen-Hua Liang; Chun-Quan Ou; Jian-Xing He; Lei Liu; Hong Shan; Chun-Liang Lei; David S C Hui; Bin Du; Lan-Juan Li; Guang Zeng; Kwok-Yung Yuen; Ru-Chong Chen; Chun-Li Tang; Tao Wang; Ping-Yan Chen; Jie Xiang; Shi-Yue Li; Jin-Lin Wang; Zi-Jing Liang; Yi-Xiang Peng; Li Wei; Yong Liu; Ya-Hua Hu; Peng Peng; Jian-Ming Wang; Ji-Yang Liu; Zhong Chen; Gang Li; Zhi-Jian Zheng; Shao-Qin Qiu; Jie Luo; Chang-Jiang Ye; Shao-Yong Zhu; Nan-Shan Zhong
Journal:  N Engl J Med       Date:  2020-02-28       Impact factor: 91.245

10.  Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China.

Authors:  L Zhang; F Zhu; L Xie; C Wang; J Wang; R Chen; P Jia; H Q Guan; L Peng; Y Chen; P Peng; P Zhang; Q Chu; Q Shen; Y Wang; S Y Xu; J P Zhao; M Zhou
Journal:  Ann Oncol       Date:  2020-03-26       Impact factor: 32.976

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