Shuai Wang1,2, Han Liu3, Yang Zhang2, Liqun Ren1. 1. Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, China. 2. Department of Vascular Surgery, The First Hospital of Jilin University, Changchun, Jilin, China. 3. Department of Respiration, The First Hospital of Jilin University, Changchun, Jilin, China.
Abstract
BACKGROUND: Animal models are well established for studying the effects of alkaloids in preventing myocardial ischemia-reperfusion injury. However, few studies have investigated the therapeutic effects of alkaloids in humans. This meta-analysis and systematic review assessed the efficacy of alkaloids in attenuating infarct size in rats with myocardial ischemia-reperfusion injury. METHODS: An integrated literature search including the PubMed, Embase, and Cochrane Library databases was performed to identify studies that evaluated the therapeutic effects of alkaloids on myocardial ischemia-reperfusion injury in rats. The main outcome was infarct size, and SYRCLE's risk of bias tool was used to assess the quality of the studies. RESULTS: 22 studies were brought into the meta-analysis. Compared with the effects of vehicle, alkaloids significantly reduced infarct size (standardized mean difference (SMD) = -0.45; 95% confidence interval (CI) = -0.64 to - 0.26). In subgroup analyses, isoquinoline alkaloids (SMD = -0.43; 95%CI = -0.70 to - 0.16) significantly reduced infarct size versus the control. CONCLUSION: Isoquinoline alkaloids can potentially alleviate myocardial ischemia-reperfusion injury. This meta-analysis and systematic review supply a reference for research programs aiming to develop alkaloid-based clinical drugs. This trial is registered with CRD42019135489.
BACKGROUND: Animal models are well established for studying the effects of alkaloids in preventing myocardial ischemia-reperfusion injury. However, few studies have investigated the therapeutic effects of alkaloids in humans. This meta-analysis and systematic review assessed the efficacy of alkaloids in attenuating infarct size in rats with myocardial ischemia-reperfusion injury. METHODS: An integrated literature search including the PubMed, Embase, and Cochrane Library databases was performed to identify studies that evaluated the therapeutic effects of alkaloids on myocardial ischemia-reperfusion injury in rats. The main outcome was infarct size, and SYRCLE's risk of bias tool was used to assess the quality of the studies. RESULTS: 22 studies were brought into the meta-analysis. Compared with the effects of vehicle, alkaloids significantly reduced infarct size (standardized mean difference (SMD) = -0.45; 95% confidence interval (CI) = -0.64 to - 0.26). In subgroup analyses, isoquinoline alkaloids (SMD = -0.43; 95%CI = -0.70 to - 0.16) significantly reduced infarct size versus the control. CONCLUSION: Isoquinoline alkaloids can potentially alleviate myocardial ischemia-reperfusion injury. This meta-analysis and systematic review supply a reference for research programs aiming to develop alkaloid-based clinical drugs. This trial is registered with CRD42019135489.
Authors: Amanda J Zatta; Hajime Kin; Darice Yoshishige; Rong Jiang; Ningping Wang; James G Reeves; James Mykytenko; Robert A Guyton; Zhi-Qing Zhao; James L Caffrey; Jakob Vinten-Johansen Journal: Am J Physiol Heart Circ Physiol Date: 2008-01-18 Impact factor: 4.733
Authors: Matthias Spindler; Klaus Meyer; Hinrik Strömer; Andrea Leupold; Ernest Boehm; Helga Wagner; Stefan Neubauer Journal: Am J Physiol Heart Circ Physiol Date: 2004-04-22 Impact factor: 4.733