| Literature DB >> 27259314 |
Kun Xing1, Xianghua Fu2, Lingling Jiang1, Yanbo Wang3, Wei Li3, Xinshun Gu3, Guozhen Hao3, Qing Miao3, Xiaolin Ge4, Yuhong Peng5, Wei Geng6, Shiru Bai1, Liye Wei7, Xile Bi1.
Abstract
Anisodamine is an ancient Chinese medicine derived from Tibet as a belladonna alkaloid, which is usually used for improvement of blood circulation in patients with organ phosphorus poisoning or shock. In this study, for the first time, we report its cardioprotective effects on preventing ischemia/reperfusion (I/R) injury of patients with acute myocardial infarction (AMI), and decreasing the myocardial infarction area and severity in heart of Sprague-Dawley (SD) rats. Our results suggest a potential molecular mechanism of anisodamine against the I/R injury in cardiomyocytes is associated with its anti-apoptotic effect. Anisodamine treatment decreases the expression of caspase-3 and caspase-8, and increases Bcl-2/Bax ratio in cardiomyocytes. Our data suggest that anisodamine can provide significant cardioprotection against I/R injury, potentially through the suppression of cardiomyocytes apoptosis.Entities:
Keywords: Acute myocardial infarction; Anisodamine; Apoptosis; H9c2 cells; Ischemia/reperfusion injury
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Year: 2015 PMID： 27259314 DOI： 10.1007/s12013-015-0642-4
Source DB: PubMed Journal: Cell Biochem Biophys ISSN： 1085-9195 Impact factor: 2.194