Literature DB >> 33782619

Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine.

Matan Levine-Tiefenbrun1, Idan Yelin2, Rachel Katz3, Esma Herzel3, Ziv Golan4, Licita Schreiber4, Tamar Wolf4, Varda Nadler4, Amir Ben-Tov3,5, Jacob Kuint3,5, Sivan Gazit3, Tal Patalon3, Gabriel Chodick3,5, Roy Kishony6,7.   

Abstract

Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12-37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.

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Year:  2021        PMID: 33782619     DOI: 10.1038/s41591-021-01316-7

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  156 in total

1.  Six months of COVID vaccines: what 1.7 billion doses have taught scientists.

Authors:  Heidi Ledford
Journal:  Nature       Date:  2021-06       Impact factor: 49.962

2.  Indirect Protection by Reducing Transmission: Ending the Pandemic With Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination.

Authors:  Aaron Richterman; Eric A Meyerowitz; Muge Cevik
Journal:  Open Forum Infect Dis       Date:  2021-05-19       Impact factor: 3.835

3.  Modelling the impact of social distancing and targeted vaccination on the spread of COVID-19 through a real city-scale contact network.

Authors:  Gavin S Hartnett; Edward Parker; Timothy R Gulden; Raffaele Vardavas; David Kravitz
Journal:  J Complex Netw       Date:  2021-12-13

4.  Evaluation of post-introduction COVID-19 vaccine effectiveness: Summary of interim guidance of the World Health Organization.

Authors:  Minal K Patel; Isabel Bergeri; Joseph S Bresee; Benjamin J Cowling; Natasha S Crowcroft; Kamal Fahmy; Siddhivinayak Hirve; Gagandeep Kang; Mark A Katz; Claudio F Lanata; Maïna L'Azou Jackson; Sudhir Joshi; Marc Lipsitch; Jason M Mwenda; Francisco Nogareda; Walter A Orenstein; Justin R Ortiz; Richard Pebody; Stephanie J Schrag; Peter G Smith; Padmini Srikantiah; Lorenzo Subissi; Marta Valenciano; David W Vaughn; Jennifer R Verani; Annelies Wilder-Smith; Daniel R Feikin
Journal:  Vaccine       Date:  2021-06-01       Impact factor: 4.169

5.  Anti-SARS-CoV-2 Receptor-Binding Domain Total Antibodies Response in Seropositive and Seronegative Healthcare Workers Undergoing COVID-19 mRNA BNT162b2 Vaccination.

Authors:  Gian Luca Salvagno; Brandon M Henry; Giovanni di Piazza; Laura Pighi; Simone De Nitto; Damiano Bragantini; Gian Luca Gianfilippi; Giuseppe Lippi
Journal:  Diagnostics (Basel)       Date:  2021-05-04

Review 6.  Delivery Routes for COVID-19 Vaccines.

Authors:  Jang Hyun Park; Heung Kyu Lee
Journal:  Vaccines (Basel)       Date:  2021-05-19

Review 7.  Long-Term Safety of Rituximab (Risks of Viral and Opportunistic Infections).

Authors:  Cara D Varley; Kevin L Winthrop
Journal:  Curr Rheumatol Rep       Date:  2021-07-16       Impact factor: 4.592

8.  Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel.

Authors:  Gili Regev-Yochay; Sharon Amit; Moriah Bergwerk; Marc Lipsitch; Eyal Leshem; Rebecca Kahn; Yaniv Lustig; Carmit Cohen; Ram Doolman; Arnona Ziv; Ilya Novikov; Carmit Rubin; Irena Gimpelevich; Amit Huppert; Galia Rahav; Arnon Afek; Yitshak Kreiss
Journal:  Lancet Reg Health Eur       Date:  2021-07-07

9.  SARS-CoV-2 Infections in mRNA Vaccinated Individuals are Biased for Viruses Encoding Spike E484K and Associated with Reduced Infectious Virus Loads that Correlate with Respiratory Antiviral IgG levels.

Authors:  Heba H Mostafa; Chun Huai Luo; C Paul Morris; Maggie Li; Nicholas J Swanson; Adannaya Amadi; Nicholas Gallagher; Andrew Pekosz
Journal:  medRxiv       Date:  2021-07-07

10.  In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness.

Authors:  Ruian Ke; Carolin Zitzmann; David D Ho; Ruy M Ribeiro; Alan S Perelson
Journal:  medRxiv       Date:  2021-06-30
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