| Literature DB >> 33782152 |
Claudio Costantini1, Emilia Nunzi1,2, Angelica Spolzino3, Melissa Palmieri1, Giorgia Renga1, Teresa Zelante1, Lukas Englmaier4, Katerina Coufalikova4, Zdeněk Spáčil4, Monica Borghi1, Marina M Bellet1, Enzo Acerbi5, Matteo Puccetti6, Stefano Giovagnoli6, Roberta Spaccapelo1,2, Vincenzo N Talesa1,2, Giuseppe Lomurno1, Francesco Merli7, Luca Facchini7, Antonio Spadea8, Lorella Melillo9, Katia Codeluppi7, Francesco Marchesi8, Gessica Marchesini10, Daniela Valente9, Giulia Dragonetti11, Gianpaolo Nadali10, Livio Pagano11,12, Franco Aversa3, Luigina Romani1,2.
Abstract
The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI.Entities:
Keywords: airway microbiome; antibiotics; hematological malignancies; indole-3-aldehyde; invasive fungal infection; metabolomics; tryptophan
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Year: 2021 PMID： 33782152 PMCID： PMC8281212 DOI： 10.1128/IAI.00105-21
Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441