Literature DB >> 33780718

CST in maintaining genome stability: Beyond telomeres.

Xinxing Lyu1, Pau Biak Sang2, Weihang Chai3.   

Abstract

The human CST (CTC1-STN1-TEN1) complex is an RPA-like single-stranded DNA binding protein complex. While its telomeric functions have been well investigated, numerous studies have revealed that hCST also plays important roles in maintaining genome stability beyond telomeres. Here, we review and discuss recent discoveries on CST in various global genome maintenance pathways, including findings on the CST supercomplex structure, its functions in unperturbed DNA replication, stalled replication, double-strand break repair, and the ATR-CHK1 activation pathway. By summarizing these recent discoveries, we hope to offer new insights into genome maintenance mechanisms and the pathogenesis of CST mutation-associated diseases.
Copyright © 2021 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  CTC1-STN1-TEN1; DNA replication; DSB repair; Fork stalling; Genome stability; Replication stress

Mesh：

Substances：

Year:  2021        PMID： 33780718      PMCID： PMC8081025          DOI： 10.1016/j.dnarep.2021.103104

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  110 in total

Review 1.  Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.

Authors:  Ci Ji Lim; Thomas R Cech
Journal:  Nat Rev Mol Cell Biol       Date:  2021-02-09       Impact factor: 94.444

2.  Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Authors:  Catherine M Phelan; Karoline B Kuchenbaecker; Jonathan P Tyrer; Siddhartha P Kar; Kate Lawrenson; Stacey J Winham; Joe Dennis; Ailith Pirie; Marjorie J Riggan; Ganna Chornokur; Madalene A Earp; Paulo C Lyra; Janet M Lee; Simon Coetzee; Jonathan Beesley; Lesley McGuffog; Penny Soucy; Ed Dicks; Andrew Lee; Daniel Barrowdale; Julie Lecarpentier; Goska Leslie; Cora M Aalfs; Katja K H Aben; Marcia Adams; Julian Adlard; Irene L Andrulis; Hoda Anton-Culver; Natalia Antonenkova; Gerasimos Aravantinos; Norbert Arnold; Banu K Arun; Brita Arver; Jacopo Azzollini; Judith Balmaña; Susana N Banerjee; Laure Barjhoux; Rosa B Barkardottir; Yukie Bean; Matthias W Beckmann; Alicia Beeghly-Fadiel; Javier Benitez; Marina Bermisheva; Marcus Q Bernardini; Michael J Birrer; Line Bjorge; Amanda Black; Kenneth Blankstein; Marinus J Blok; Clara Bodelon; Natalia Bogdanova; Anders Bojesen; Bernardo Bonanni; Åke Borg; Angela R Bradbury; James D Brenton; Carole Brewer; Louise Brinton; Per Broberg; Angela Brooks-Wilson; Fiona Bruinsma; Joan Brunet; Bruno Buecher; Ralf Butzow; Saundra S Buys; Trinidad Caldes; Maria A Caligo; Ian Campbell; Rikki Cannioto; Michael E Carney; Terence Cescon; Salina B Chan; Jenny Chang-Claude; Stephen Chanock; Xiao Qing Chen; Yoke-Eng Chiew; Jocelyne Chiquette; Wendy K Chung; Kathleen B M Claes; Thomas Conner; Linda S Cook; Jackie Cook; Daniel W Cramer; Julie M Cunningham; Aimee A D'Aloisio; Mary B Daly; Francesca Damiola; Sakaeva Dina Damirovna; Agnieszka Dansonka-Mieszkowska; Fanny Dao; Rosemarie Davidson; Anna DeFazio; Capucine Delnatte; Kimberly F Doheny; Orland Diez; Yuan Chun Ding; Jennifer Anne Doherty; Susan M Domchek; Cecilia M Dorfling; Thilo Dörk; Laure Dossus; Mercedes Duran; Matthias Dürst; Bernd Dworniczak; Diana Eccles; Todd Edwards; Ros Eeles; Ursula Eilber; Bent Ejlertsen; Arif B Ekici; Steve Ellis; Mingajeva Elvira; Kevin H Eng; Christoph Engel; D Gareth Evans; Peter A Fasching; Sarah Ferguson; Sandra Fert Ferrer; James M Flanagan; Zachary C Fogarty; Renée T Fortner; Florentia Fostira; William D Foulkes; George Fountzilas; Brooke L Fridley; Tara M Friebel; Eitan Friedman; Debra Frost; Patricia A Ganz; Judy Garber; María J García; Vanesa Garcia-Barberan; Andrea Gehrig; Aleksandra Gentry-Maharaj; Anne-Marie Gerdes; Graham G Giles; Rosalind Glasspool; Gord Glendon; Andrew K Godwin; David E Goldgar; Teodora Goranova; Martin Gore; Mark H Greene; Jacek Gronwald; Stephen Gruber; Eric Hahnen; Christopher A Haiman; Niclas Håkansson; Ute Hamann; Thomas V O Hansen; Patricia A Harrington; Holly R Harris; Jan Hauke; Alexander Hein; Alex Henderson; Michelle A T Hildebrandt; Peter Hillemanns; Shirley Hodgson; Claus K Høgdall; Estrid Høgdall; Frans B L Hogervorst; Helene Holland; Maartje J Hooning; Karen Hosking; Ruea-Yea Huang; Peter J Hulick; Jillian Hung; David J Hunter; David G Huntsman; Tomasz Huzarski; Evgeny N Imyanitov; Claudine Isaacs; Edwin S Iversen; Louise Izatt; Angel Izquierdo; Anna Jakubowska; Paul James; Ramunas Janavicius; Mats Jernetz; Allan Jensen; Uffe Birk Jensen; Esther M John; Sharon Johnatty; Michael E Jones; Päivi Kannisto; Beth Y Karlan; Anthony Karnezis; Karin Kast; Catherine J Kennedy; Elza Khusnutdinova; Lambertus A Kiemeney; Johanna I Kiiski; Sung-Won Kim; Susanne K Kjaer; Martin Köbel; Reidun K Kopperud; Torben A Kruse; Jolanta Kupryjanczyk; Ava Kwong; Yael Laitman; Diether Lambrechts; Nerea Larrañaga; Melissa C Larson; Conxi Lazaro; Nhu D Le; Loic Le Marchand; Jong Won Lee; Shashikant B Lele; Arto Leminen; Dominique Leroux; Jenny Lester; Fabienne Lesueur; Douglas A Levine; Dong Liang; Clemens Liebrich; Jenna Lilyquist; Loren Lipworth; Jolanta Lissowska; Karen H Lu; Jan Lubinński; Craig Luccarini; Lene Lundvall; Phuong L Mai; Gustavo Mendoza-Fandiño; Siranoush Manoukian; Leon F A G Massuger; Taymaa May; Sylvie Mazoyer; Jessica N McAlpine; Valerie McGuire; John R McLaughlin; Iain McNeish; Hanne Meijers-Heijboer; Alfons Meindl; Usha Menon; Arjen R Mensenkamp; Melissa A Merritt; Roger L Milne; Gillian Mitchell; Francesmary Modugno; Joanna Moes-Sosnowska; Melissa Moffitt; Marco Montagna; Kirsten B Moysich; Anna Marie Mulligan; Jacob Musinsky; Katherine L Nathanson; Lotte Nedergaard; Roberta B Ness; Susan L Neuhausen; Heli Nevanlinna; Dieter Niederacher; Robert L Nussbaum; Kunle Odunsi; Edith Olah; Olufunmilayo I Olopade; Håkan Olsson; Curtis Olswold; David M O'Malley; Kai-Ren Ong; N Charlotte Onland-Moret; Nicholas Orr; Sandra Orsulic; Ana Osorio; Domenico Palli; Laura Papi; Tjoung-Won Park-Simon; James Paul; Celeste L Pearce; Inge Søkilde Pedersen; Petra H M Peeters; Bernard Peissel; Ana Peixoto; Tanja Pejovic; Liisa M Pelttari; Jennifer B Permuth; Paolo Peterlongo; Lidia Pezzani; Georg Pfeiler; Kelly-Anne Phillips; Marion Piedmonte; Malcolm C Pike; Anna M Piskorz; Samantha R Poblete; Timea Pocza; Elizabeth M Poole; Bruce Poppe; Mary E Porteous; Fabienne Prieur; Darya Prokofyeva; Elizabeth Pugh; Miquel Angel Pujana; Pascal Pujol; Paolo Radice; Johanna Rantala; Christine Rappaport-Fuerhauser; Gad Rennert; Kerstin Rhiem; Patricia Rice; Andrea Richardson; Mark Robson; Gustavo C Rodriguez; Cristina Rodríguez-Antona; Jane Romm; Matti A Rookus; Mary Anne Rossing; Joseph H Rothstein; Anja Rudolph; Ingo B Runnebaum; Helga B Salvesen; Dale P Sandler; Minouk J Schoemaker; Leigha Senter; V Wendy Setiawan; Gianluca Severi; Priyanka Sharma; Tameka Shelford; Nadeem Siddiqui; Lucy E Side; Weiva Sieh; Christian F Singer; Hagay Sobol; Honglin Song; Melissa C Southey; Amanda B Spurdle; Zsofia Stadler; Doris Steinemann; Dominique Stoppa-Lyonnet; Lara E Sucheston-Campbell; Grzegorz Sukiennicki; Rebecca Sutphen; Christian Sutter; Anthony J Swerdlow; Csilla I Szabo; Lukasz Szafron; Yen Y Tan; Jack A Taylor; Muy-Kheng Tea; Manuel R Teixeira; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Liv Cecilie Vestrheim Thomsen; Darcy L Thull; Laima Tihomirova; Anna V Tinker; Marc Tischkowitz; Silvia Tognazzo; Amanda Ewart Toland; Alicia Tone; Britton Trabert; Ruth C Travis; Antonia Trichopoulou; Nadine Tung; Shelley S Tworoger; Anne M van Altena; David Van Den Berg; Annemarie H van der Hout; Rob B van der Luijt; Mattias Van Heetvelde; Els Van Nieuwenhuysen; Elizabeth J van Rensburg; Adriaan Vanderstichele; Raymonda Varon-Mateeva; Ana Vega; Digna Velez Edwards; Ignace Vergote; Robert A Vierkant; Joseph Vijai; Athanassios Vratimos; Lisa Walker; Christine Walsh; Dorothea Wand; Shan Wang-Gohrke; Barbara Wappenschmidt; Penelope M Webb; Clarice R Weinberg; Jeffrey N Weitzel; Nicolas Wentzensen; Alice S Whittemore; Juul T Wijnen; Lynne R Wilkens; Alicja Wolk; Michelle Woo; Xifeng Wu; Anna H Wu; Hannah Yang; Drakoulis Yannoukakos; Argyrios Ziogas; Kristin K Zorn; Steven A Narod; Douglas F Easton; Christopher I Amos; Joellen M Schildkraut; Susan J Ramus; Laura Ottini; Marc T Goodman; Sue K Park; Linda E Kelemen; Harvey A Risch; Mads Thomassen; Kenneth Offit; Jacques Simard; Rita Katharina Schmutzler; Dennis Hazelett; Alvaro N Monteiro; Fergus J Couch; Andrew Berchuck; Georgia Chenevix-Trench; Ellen L Goode; Thomas A Sellers; Simon A Gayther; Antonis C Antoniou; Paul D P Pharoah
Journal:  Nat Genet       Date:  2017-03-27       Impact factor: 38.330

3.  Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

Authors:  Alberto Ciccia; Amitabh V Nimonkar; Yiduo Hu; Ildiko Hajdu; Yathish Jagadheesh Achar; Lior Izhar; Sarah A Petit; Britt Adamson; John C Yoon; Stephen C Kowalczykowski; David M Livingston; Lajos Haracska; Stephen J Elledge
Journal:  Mol Cell       Date:  2012-06-14       Impact factor: 17.970

4.  Human CST Prefers G-Rich but Not Necessarily Telomeric Sequences.

Authors:  Robert A Hom; Deborah S Wuttke
Journal:  Biochemistry       Date:  2017-08-02       Impact factor: 3.162

Review 5.  Non-homologous DNA end joining and alternative pathways to double-strand break repair.

Authors:  Howard H Y Chang; Nicholas R Pannunzio; Noritaka Adachi; Michael R Lieber
Journal:  Nat Rev Mol Cell Biol       Date:  2017-05-17       Impact factor: 94.444

6.  ATR signaling at a glance.

Authors:  Bunsyo Shiotani; Lee Zou
Journal:  J Cell Sci       Date:  2009-02-01       Impact factor: 5.285

Review 7.  Coats plus syndrome (cerebroretinal microangiopathy with calcifications and cysts-1): A case report.

Authors:  Francisca Morgado; Mariana Batista; Ana Moreno; Inês Coutinho
Journal:  Pediatr Dermatol       Date:  2020-10-03       Impact factor: 1.588

8.  The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair.

Authors:  Shuren Liao; Margaret Tammaro; Hong Yan
Journal:  Nucleic Acids Res       Date:  2016-04-15       Impact factor: 16.971

Review 9.  Advances in understanding DNA processing and protection at stalled replication forks.

Authors:  Kimberly Rickman; Agata Smogorzewska
Journal:  J Cell Biol       Date:  2019-01-22       Impact factor: 10.539

10.  STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.

Authors:  Anukana Bhattacharjee; Jason Stewart; Mary Chaiken; Carolyn M Price
Journal:  PLoS Genet       Date:  2016-09-30       Impact factor: 5.917
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  2 in total

1.  Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1.

Authors:  Arunabh Choudhury; Taj Mohammad; Nikhil Samarth; Afzal Hussain; Md Tabish Rehman; Asimul Islam; Mohamed F Alajmi; Shailza Singh; Md Imtaiyaz Hassan
Journal:  Sci Rep       Date:  2021-05-13       Impact factor: 4.379

Review 2.  Stress and telomere shortening: Insights from cellular mechanisms.

Authors:  Jue Lin; Elissa Epel
Journal:  Ageing Res Rev       Date:  2021-11-01       Impact factor: 10.895
  2 in total

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