| Literature DB >> 33779927 |
Ramasamy Subbiah1, Divya Sridharan2, Karthika Duairaj1, K Shanmugha Rajan3, Mahmood Khan2,4, Venkata Naga Srikanth Garikipati5.
Abstract
Cardiovascular disease is the leading cause of morbidity and mortality all over the world. Emerging evidence emphasize the importance of extracellular vesicles (EVs) in the cell to cell communication in the cardiovascular system which is majorly mediated through non-coding RNA cargo. Advancement in sequencing technologies revealed a major proportion of human genome is composed of non-coding RNAs viz., miRNAs, lncRNAs, tRNAs, snoRNAs, piRNAs and rRNAs. However, our understanding of the role of ncRNAs-containing EVs in cardiovascular health and disease is still in its infancy. This book chapter provides a comprehensive update on our understanding on the role of EVs derived ncRNAs in the cardiovascular pathophysiology and their therapeutic potential.Entities:
Keywords: Cardiovascular disease; Extracellular Vesicles; circular RNA; lncRNA; miRNA
Mesh：
Substances：
Year: 2021 PMID： 33779927 DOI： 10.1007/978-3-030-67171-6_17
Source DB: PubMed Journal: Subcell Biochem ISSN： 0306-0225