| Literature DB >> 26073943 |
Olaf Bergmann1, Sofia Zdunek2, Anastasia Felker2, Mehran Salehpour3, Kanar Alkass4, Samuel Bernard5, Staffan L Sjostrom2, Mirosława Szewczykowska6, Teresa Jackowska7, Cris Dos Remedios8, Torsten Malm9, Michaela Andrä10, Ramadan Jashari11, Jens R Nyengaard12, Göran Possnert3, Stefan Jovinge13, Henrik Druid14, Jonas Frisén15.
Abstract
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.Entities:
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Year: 2015 PMID： 26073943 DOI： 10.1016/j.cell.2015.05.026
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582