Flávia Borges-Machado1, Duarte Barros1, Laetitia Teixeira2,3, Óscar Ribeiro4, Joana Carvalho5,6. 1. CIAFEL, Centro de Investigação em Atividade Física, Saúde e Lazer, Universidade do Porto, Porto, Portugal. 2. Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal. 3. CINTESIS, Centro de Investigação em Tecnologias e Serviços de Saúde, Porto, Portugal. 4. Departamento de Educação e Psicologia, Universidade de Aveiro, Aveiro, Portugal. 5. CIAFEL, Centro de Investigação em Atividade Física, Saúde e Lazer, Universidade do Porto, Porto, Portugal. jcarvalho@fade.up.pt. 6. Faculdade de Desporto, Universidade do Porto, Porto, Portugal. jcarvalho@fade.up.pt.
Abstract
PURPOSE: This study aimed to identify the association between health-related physical indicators-sarcopenia-related factors, physical fitness, independence in activities of daily living (ADL) and habitual physical activity-and self-rated quality of life (QoL) in people with neurocognitive disorder (NCD). METHODS: This cross-sectional study included 115 participants (78.22 ± 7.48 years; 74.8% female) clinically diagnosed with NCD. Self-rated QoL was evaluated using The Quality of Life-Alzheimer's Disease (QoL-AD). Dual energy X-ray Absorptiometry, handgrip strength, Short Physical Performance Battery, and the 6-m Walk test were used to assess sarcopenia-related factors. Senior Fitness Test and One Leg Balance test, Barthel Index, Baecke Modified Habitual Physical Activity Questionnaire were used to determine physical fitness, independence in ADL and physical activity, respectively. Regressions analyses were performed to examine associations between these variables and QoL-AD. RESULTS: Data from univariable linear regression analysis revealed that self-rated QoL was associated with sarcopenia-related factors (lower body function, handgrip strength, gait speed, and appendicular skeletal muscle mass index-ASMI), physical fitness (upper-and-lower-body strength, agility/dynamic balance, cardiorespiratory fitness and body mass index), habitual physical activity and independence in ADL. Results from multivariable regression analysis showed that ASMI (B = 1.846, 95% CI 0.165-3.527, p = 0.032) and lower body function (B = 0.756, 95% CI 0.269-1.242, p = 0.003) were positively associated with self-rated QoL. These variables explained 20.1% of the variability seen in self-rated QoL, controlling for age, sex, marital status and education. CONCLUSION: Sarcopenia-related factors, namely lower body function and ASMI, should be acknowledged in future research studies as critical health-related indicators associated with QoL in people with NCD. TRIAL REGISTRATION: ClinicalTrials.gov-identifier number NCT04095962.
PURPOSE: This study aimed to identify the association between health-related physical indicators-sarcopenia-related factors, physical fitness, independence in activities of daily living (ADL) and habitual physical activity-and self-rated quality of life (QoL) in people with neurocognitive disorder (NCD). METHODS: This cross-sectional study included 115 participants (78.22 ± 7.48 years; 74.8% female) clinically diagnosed with NCD. Self-rated QoL was evaluated using The Quality of Life-Alzheimer's Disease (QoL-AD). Dual energy X-ray Absorptiometry, handgrip strength, Short Physical Performance Battery, and the 6-m Walk test were used to assess sarcopenia-related factors. Senior Fitness Test and One Leg Balance test, Barthel Index, Baecke Modified Habitual Physical Activity Questionnaire were used to determine physical fitness, independence in ADL and physical activity, respectively. Regressions analyses were performed to examine associations between these variables and QoL-AD. RESULTS: Data from univariable linear regression analysis revealed that self-rated QoL was associated with sarcopenia-related factors (lower body function, handgrip strength, gait speed, and appendicular skeletal muscle mass index-ASMI), physical fitness (upper-and-lower-body strength, agility/dynamic balance, cardiorespiratory fitness and body mass index), habitual physical activity and independence in ADL. Results from multivariable regression analysis showed that ASMI (B = 1.846, 95% CI 0.165-3.527, p = 0.032) and lower body function (B = 0.756, 95% CI 0.269-1.242, p = 0.003) were positively associated with self-rated QoL. These variables explained 20.1% of the variability seen in self-rated QoL, controlling for age, sex, marital status and education. CONCLUSION:Sarcopenia-related factors, namely lower body function and ASMI, should be acknowledged in future research studies as critical health-related indicators associated with QoL in people with NCD. TRIAL REGISTRATION: ClinicalTrials.gov-identifier number NCT04095962.
Authors: Teake P Ettema; Rose-Marie Dröes; Jacomine de Lange; Gideon J Mellenbergh; Miel W Ribbe Journal: Qual Life Res Date: 2005-04 Impact factor: 4.147
Authors: Betty S Black; Deirdre Johnston; Ann Morrison; Peter V Rabins; Constantine G Lyketsos; Quincy M Samus Journal: Qual Life Res Date: 2011-10-26 Impact factor: 4.147
Authors: Anthony Martyr; Sharon M Nelis; Catherine Quinn; Yu-Tzu Wu; Ruth A Lamont; Catherine Henderson; Rachel Clarke; John V Hindle; Jeanette M Thom; Ian Rees Jones; Robin G Morris; Jennifer M Rusted; Christina R Victor; Linda Clare Journal: Psychol Med Date: 2018-05-08 Impact factor: 7.723
Authors: J P Browne; C A O'Boyle; H M McGee; C R Joyce; N J McDonald; K O'Malley; B Hiltbrunner Journal: Qual Life Res Date: 1994-08 Impact factor: 4.147
Authors: Luis Leitão; Gabriela R O Venturini; Ricardo Pace Junior; Estêvão Rios Monteiro; Luiz Guilherme Telles; Gleisson Araújo; Jefferson Novaes; Carlos Tavares; Sílvio Marques-Neto; Mauro Mazini Journal: Int J Environ Res Public Health Date: 2022-09-18 Impact factor: 4.614