Literature DB >> 33778390

A randomized trial analyzing the effects of primary versus delayed primary closure of incision on wound healing in patients with hollow viscus perforation.

Aditya Baksi1, Shamita Chatterjee2, Udipta Ray3, Nilima Nilima4, Washim Firoz Khan1, Niladri Banerjee1.   

Abstract

OBJECTIVES: Delayed primary closure (DPC) of the skin has been suggested to decrease superficial surgical site infection (SSSI) in patients undergoing surgery for peritonitis secondary to hollow viscus perforation, but there is no consensus. The aim of this study was to compare the outcomes of primary closure (PC) and DPC of the skin in terms of SSSI, fascial dehiscence and length of hospital stay (LOS).
MATERIAL AND METHODS: Sixty patients, undergoing emergency surgery for perforation peritonitis, were randomized to PC (n= 30) and DPC (n= 30). Patients in the DPC group underwent skin closure four or more days after surgery when the wound was clinically considered appropriate for closure. Patients in the PC group had skin closure at the time of surgery.
RESULTS: Incidence of SSSI was significantly less in the DPC group (7.4%) compared to the PC (42.9%) (p= 0.004). However, the median time of DPC was the 10th POD, i.e., these wounds required considerable time to become clinically suitable for closure. Incidence of fascial dehiscence was comparable between the two groups (p= 0.67). Length of hospital stay (LOS) was 13.8 days in the DPC group compared to 13.5 days in PC; the difference was not significant (p= 0.825).
CONCLUSION: DPC of the skin incision resulted in the reduction of SSSI. However, this did not translate into a reduction in hospital stay, as it took considerable time for these wounds to become appropriate for DPC, thus bringing into question any real advantage of DPC over PC.
Copyright © 2020, Turkish Surgical Society.

Entities:  

Year:  2020        PMID: 33778390      PMCID: PMC7963304          DOI: 10.47717/turkjsurg.2020.4882

Source DB:  PubMed          Journal:  Turk J Surg        ISSN: 2564-6850


  15 in total

1.  Wound infections following potentially contaminated operations. Effect of delayed primary closure of the skin and subcutaneous tissue.

Authors:  H R BERNARD; W R COLE
Journal:  JAMA       Date:  1963-04-27       Impact factor: 56.272

2.  DELAYED PRIMARY SUTURE OF WOUNDS.

Authors:  H H Hepburn
Journal:  Br Med J       Date:  1919-02-15

Review 3.  Systemic review and meta-analysis of randomized clinical trials comparing primary vs delayed primary skin closure in contaminated and dirty abdominal incisions.

Authors:  Aneel Bhangu; Prashant Singh; Jonathan Lundy; Douglas M Bowley
Journal:  JAMA Surg       Date:  2013-08       Impact factor: 14.766

4.  Primary Versus Delayed Primary Incision Closure in Contaminated Abdominal Surgery: A Meta-Analysis.

Authors:  Sumin Tang; Wei Hu; Lili Hu; Jun Zhou
Journal:  J Surg Res       Date:  2019-02-19       Impact factor: 2.192

Review 5.  Primary versus delayed wound closure in complicated appendicitis: an international systematic review and meta-analysis.

Authors:  Marion C W Henry; R Lawrence Moss
Journal:  Pediatr Surg Int       Date:  2005-10-13       Impact factor: 1.827

6.  Prevention of wound infection in perforated appendicitis: experience with delayed primary wound closure.

Authors:  J L Grosfeld; R W Solit
Journal:  Ann Surg       Date:  1968-11       Impact factor: 12.969

7.  Delayed primary closure versus primary closure for wound management in perforated appendicitis: a prospective randomized controlled trial.

Authors:  Ruey-An Chiang; Shan-Long Chen; Yao-Chung Tsai
Journal:  J Chin Med Assoc       Date:  2012-03-30       Impact factor: 2.743

8.  Delayed primary wound closure in gangrenous and perforated appendicitis.

Authors:  R A Pettigrew
Journal:  Br J Surg       Date:  1981-09       Impact factor: 6.939

9.  Comparison of Superficial Surgical Site Infection Between Delayed Primary Versus Primary Wound Closure in Complicated Appendicitis: A Randomized Controlled Trial.

Authors:  Boonying Siribumrungwong; Anuwat Chantip; Pinit Noorit; Chumpon Wilasrusmee; Winai Ungpinitpong; Pradya Chotiya; Borwornsom Leerapan; Patarawan Woratanarat; Mark McEvoy; John Attia; Ammarin Thakkinstian
Journal:  Ann Surg       Date:  2018-04       Impact factor: 12.969

Review 10.  A systematic review and meta-analysis of randomised controlled trials of delayed primary wound closure in contaminated abdominal wounds.

Authors:  Boonying Siribumrungwong; Pinit Noorit; Chumpon Wilasrusmee; Ammarin Thakkinstian
Journal:  World J Emerg Surg       Date:  2014-09-06       Impact factor: 5.469

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